Clinical trials: Disorders of Sex Development
HIV Infections
HIV Assessment in Fuyang, Anhui Province, China
The purpose of this study was to examine the needs, concerns, stigmas, and social networks of HIV infected former plasma donors (FPDs) and their relatives in Fuyang, Anhui Province, China.
- Trial name
- NCT00094354
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, HIV/AIDS
Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa
The purpose of this early Phase 2 comparison trial is to evaluate the impact of community health worker (CHW) home visitors on pregnant women and their children in a rural setting in the rural Eastern Cape of South Africa.
- Conditions
- HIV Infections, HIV/AIDS, Depression, Depressive Symptoms
- Trial name
- NCT03517878
- Testing
- Comprehensive CHW Program
- Where
- 2 sites in South Africa
- Volunteers
- 1,490 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Klinefelter Syndrome
Subcapsular Orchiectomy in Men With Klinefelter Syndrome
Men with Klinefelter syndrome undergo unilateral subcapsular ochiectomy, and the removed testicular tissue is examined for presence of sperm and cryopreserved in small pieces for fertility treatment and scientific purposes.
- Trial name
- NCT01750632
- Testing
- Orchiectomy
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Odense University Hospital
LGBTQ, Racial Disparities
Lakota Family Acceptance Project
The goal of this open pilot trial (OPT) is to develop a Lakota-adapted Family Acceptance Project (LFAP) for Indigenous 2SLGBTQ+ youth and their caregivers.
- Conditions
- LGBTQ, Racial Disparities, Family Relationships, Minority Stress
- Trial name
- L-FAP OPT (NCT07326748)
- Testing
- Adapted Lakota Family Acceptance Program
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Klinefelter Syndrome, Turner Syndrome
Turner And Klinefelter Treatment Target Study
Rationale: Health related Quality of life (HRQoL) is impaired in patients with Turner and Klinefelter syndrome (TS and KS). It is unknown what the optimal endocrine treatment target values are that maximize HRQoL in patients with…
- Trial name
- TAKTT (NCT04803474)
- Testing
- Measurement of blood values, questionnaire scores and measurements of hormone levels in hair
- Where
- Netherlands
- Volunteers
- 370 people
- Sponsor
- dr. Laura C. G. de Graaff-Herder
HIV-1, AIDS
HLA-B35 Alleles and AIDS
This study will identify variations in the genome of the human immunodeficiency virus (HIV) early after infection and following the development of AIDS.
- Trial name
- NCT00340223
- Where
- 7 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Classic Congenital Adrenal Hyperplasia, 21-Hydroxylase Deficiency
Pediatric Congenital Adrenal Hyperplasia Management: Regret and Long-term Outcomes
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is a chronic endocrine disorder, often diagnosed in the neonatal period. Severe forms may lead to genital virilization in afected girls and adrenal crises.
- Trial name
- CAH - REC (NCT07781267)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Gender Identity, Gender Dysphoria in Adolescents and Adults
Puberty, Testosterone, and Brain Development
Transmasculine youth (female sex assigned at birth, male gender identity) who begin clinical gender affirming hormone therapy (GAHT) with testosterone (T) may experience changes in headache.
- Conditions
- Gender Identity, Gender Dysphoria in Adolescents and Adults, Headache, Transgender
- Trial name
- NCT06670053
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy
Non-invasive Prenatal Diagnostic Validation Study
The primary purpose of this study is to collect maternal blood samples from pregnant women to develop a non-invasive prenatal diagnostic test based on fetal DNA isolated from maternal blood.
- Conditions
- Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy, Chromosome 21 Aneuploidy, Sex Chromosome Aberrations
- Trial name
- NIPD (NCT01574781)
- Testing
- Blood draw, Cheek swab/Saliva Sampling
- Where
- United States
- Volunteers
- 1,781 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Klinefelter Syndrome, Thyroiditis, Autoimmune
Thyroid Function and Structure in Klinefelter Syndrome
This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.
- Conditions
- Klinefelter Syndrome, Thyroiditis, Autoimmune, Hypothyroidism
- Trial name
- THINKS (NCT05581147)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University of Roma La Sapienza
Disorder of Sex Development, 46,XY
Testosterone Treatment in a Patient With 17β-hydroxysteroid Dehydrogenase Type 3 Deficiency: an N-of-1 Study
A 38-year old women with a 46,XY disorder of sex development (DSD) based on a 17β-hydroxysteroid dehydrogenase type 3 deficiency (17β-HSD3) was seen at the department of Internal Medicine-Endocrinology at the Erasmus MC…
- Trial name
- N-of-1 DSD (NCT04831099)
- Testing
- Testosterone gel
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Erasmus Medical Center
Congenital Adrenal Hyperplasia
Gonadal Changes In Congenital Adrenal Hyperplasia Patients
To detect the prevalence of gonadal changes by US among the patients with CAH. assess the patients' radiological findings in relation to their hormonal profile.
- Trial name
- NCT04903587
- Testing
- Ultrasonography and MRI
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Sexual Behavior, Conflict, Family
Heart to Heart: Testing a Sexual Health Training for Foster and Kinship Caregivers
Heart to Heart is a brief pregnancy prevention training program delivered to foster and kinship caregivers to prevent unintended pregnancy in foster youth.
- Conditions
- Sexual Behavior, Conflict, Family, Pregnancy Related, Sexually Transmitted Diseases
- Trial name
- NCT03331016
- Testing
- Heart to Heart Training
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Polycystic Ovary Syndrome
PCOS Twin Study - Environmental Factors in the Development of Polycystic Ovary Syndrome, Phase 2
Polycystic Ovary Syndrome, or PCOS, is the most common endocrine disorder in women. Depending on the strictness of the diagnostic criteria used, it is thought to occur in about 6-10% of all women, many of whom do not know they…
- Trial name
- NCT00444288
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders
The aims of this study are: 1) to identify genes that play a role in human pubertal development and reproduction, 2) to characterize the phenotypic spectrum of patients with these gene defects, and 3) to discern the mode of…
- Conditions
- Hypogonadotropic Hypogonadism, Kallmann Syndrome, Puberty, Delayed, Puberty, Precocious
- Trial name
- NCT00494169
- Where
- United States
- Volunteers
- 4,042 people
- Sponsor
- Massachusetts General Hospital
Disorders of Sex Development, Congenital Adrenal Hyperplasia
Gene Polymorphisms Influencing Steroid Synthesis and Action
The extend of steroid biosynthesis and action is mainly dependent on underlying genetic polymorphisms and gene mutations. These sequence variations in multiple genes involved in steroid biosynthesis and action cause different…
- Conditions
- Disorders of Sex Development, Congenital Adrenal Hyperplasia, Congenital Adrenal Hypoplasia, Adrenal Insufficiency
- Trial name
- NCT00485186
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Male Factor Infertility, Female Factor Infertility
The Clinical Study of Sex Chromosome Variants
Purpose/Lay Summary: Background: Chromosomes are the structures inside of each cell that carry our genetic material (genes). Certain differences in the sex chromosomes are known to cause various diseases, such as infertility…
- Trial name
- NCT01661010
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
PCOS, Hyperandrogenism
The Effect of Ibuprofen on Women With PCOS.
Polycystic ovary syndrome occurs in about 10% of women of childbearing age. His pathogenesis is not fully understood. More and more research concerns the role of chronic inflammation in these women as the cause of the disease.
- Conditions
- PCOS, Hyperandrogenism, Inflammation
- Trial name
- NCT04485403
- Testing
- Ibuprofen
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Poznan University of Medical Sciences
Autism Spectrum Disorder
Evaluation of Skillflix for Parents of Youth With ASD
The goal of this clinical trial is to evaluate the effectiveness of using a Microskills video training library for training parents of adolescents with ASD in talking with their teens about relationships and sexual health topics.
- Trial name
- NCT05958394
- Testing
- SkillFlix for Parents
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ashley Philliber
Hypothalamic Obesity
A Trial of Setmelanotide in Acquired Hypothalamic Obesity
The goal of this trial is to learn how well Setmelanotide works to improve weight reduction, hunger, and quality of life in patients 4 years of age and older with acquired Hypothalamic Obesity (HO).
- Trial name
- NCT05774756
- Testing
- Setmelanotide
- Where
- 28 sites in United States, Canada and 4 more
- Volunteers
- 143 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.