Clinical trials: Disorders of Consciousness
Disorders of Consciousness
Tactile Stimulation in Disorders of Consciousness (DoC)
The aim of this project is to evaluate the behavioural and neurophysiological responses to pleasant touch in patients with disorders of consciousness (DoC) and to determine whether these responses are related to the level of…
- Trial name
- TACTILE-DOC (NCT06922123)
- Testing
- Tactile stimulation, Neurophysiological Monitoring with SedLine
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Anna Estraneo
Coma, Major Trauma
Succinylcholine vs Rocuronium for Prehospital Emergency Intubation
All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included in order to compare the use of succinylcholine vs Rocuronium for prehospital emergency…
- Conditions
- Coma, Major Trauma, Respiratory Distress, Shock
- Trial name
- CURASMUR (NCT02000674)
- Testing
- Succinylcholine : 1mg/kg, Rocuronium : 1.2 mg/kg
- Where
- 17 sites in France
- Volunteers
- 1,321 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Fibromyalgia Syndrome, Fibromyalgia Impact Questionnaire
Effects of Conscious Connected Breathing Exercises on Fibromyalgia
Our aim in this study is to investigate the effects of conscious connected breathing exercises on sexual function, sleep, and mood in fibromyalgia patients.
- Conditions
- Fibromyalgia Syndrome, Fibromyalgia Impact Questionnaire, Breathing Pattern Disorder, Female Sexual Dysfunction (FSD)
- Trial name
- NCT07030374
- Testing
- conscious connected breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Adana City Training and Research Hospital
Depression
An Investigation Into the Effects of Blueberry Anthocyanin on Cognitive Functioning and Mood in Adolescents.
The purpose of this study is to determine whether a 4-week dietary intervention with wild blueberry powder can have an effect on cognitive performance in participants aged between 13-17.
- Trial name
- NCT03119597
- Testing
- Wild Blueberry Powder-13g
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Reading
Pregnancy, Abdominal, Termination of Pregnancy
TENS for Suction Evacuation for Termination of 1st Trimester Pregnancies
To study the effectiveness of the pain relief method of transcutaneous electrical nerve stimulation (TENS) for women who will undergo suction evacuation under conscious sedation for first trimester termination of pregnancy.
- Conditions
- Pregnancy, Abdominal, Termination of Pregnancy, Pain, Nerve
- Trial name
- NCT03494842
- Testing
- Transcutaneous nerve stimulation (TENS)
- Where
- Hong Kong
- Volunteers
- 170 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Syncope
Theophylline for Low Adenosine Syncope
The study aims at assessing that theophylline is effective in patients with no prodromes, normal heart and with low values of plasmatic adenosine compared with a propensity-score matched untreated control population who have…
- Trial name
- THEO-USA (NCT03803215)
- Testing
- Theophylline
- Where
- Italy
- Volunteers
- 77 people
- Sponsor
- Centro Prevenzione Malattie Cardiovascolari N. e V. Corbella
Brain Injury, Coma, Cardiac Arrest (CA)
Prediction for Coma Recovery With Comaweb
The general objective of the comaScore project is to provide an external validation of the accuracy of the comaScore, a score derived from magnetic resonance imaging (MRI), to predict 1 year outcome of patients unresponsive to…
- Conditions
- Brain Injury, Coma, Cardiac Arrest (CA), Traumatic Brain Injury (TBI), Aneurysmal Subarachnoid Hemorrhages (aSAH)
- Trial name
- COMASCORE (NCT03874208)
- Testing
- MRI sequence, MRI
- Where
- France
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Consciousness Disorder, Transcranial Direct Current Stimulation
tDCS in Patients With Disorders of Consciousness
test
- Trial name
- NCT03475537
- Testing
- transcranial direct current stimulation
- Where
- China
- Sponsor
- First Affiliated Hospital of Zhejiang University
Brain Injury
Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury
The purpose of this study is to test the drug apomorphine in subjects who are in a Vegetative State or a Minimally Conscious State.
- Trial name
- NH001-2 (NCT00761228)
- Testing
- Apomorphine
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- NeuroHealing Pharmaceuticals Inc.
Coma
Role of Intravenous Lipid Emulsion in Improving Coma of Acute Antipsychotics Poisoning
Intravenous Lipid Emulsion in Improving Coma Of Antipsychotic drugs Acute Poisoning: A Randomized Controlled Trial in Poison Control Center of Ain Shams University Hospitals
- Trial name
- NCT04807634
- Testing
- Intravenous Lipid Emulsion (Intralipid 20%)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Arhythmia, Atrioventricular Heart-block
Observation of ImageReady™ MR Conditional Pacing System in China
To observe the safety and efficacy of ImageReady™ MR Conditional Pacing System in Chinese subjects
- Conditions
- Arhythmia, Atrioventricular Heart-block, Chronic Bundle Branch or Branch Block, Carotid Sinus Hypersensitivity Reaction Syndrome
- Trial name
- NCT02636712
- Testing
- ImageReady™ MR Conditional Pacing System
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Boston Scientific Corporation
Brain Injury
A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness
This is a study to evaluate the safety and efficacy of the IBRF ACP/MCP intervention protocol in patients with severe disorders of consciousness (SDOC).
- Trial name
- NCT02696512
- Testing
- Polypharmacy using FDA-approved products, Median Nerve Stimulation (MNS), Nutraceutical Supplementation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- International Brain Research Foundation
Syncope, Vasovagal, Blood, Injection, Injury Type Phobia
Impact of Blood Phobia on Fainting Susceptibility
The primary purpose of this study is to characterize cardiovascular autonomic function to emotional stimuli (blood-injection-injury phobia [needle phobia]) during an orthostatic (upright) challenge in individuals with and without…
- Trial name
- NCT06336031
- Testing
- blood-injection-injury (BII) phobia stimuli, neutral stimuli
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ATRIAL FIBRILLATION, Syncope
BioMonitor Master Study
The BioMonitor is an implantable cardiac monitor used to automatically detect and record episodes of arrhythmia in patients with bradycardia, tachycardia, asystole and atrial fibrillation.
- Trial name
- BioMonitor (NCT01725568)
- Testing
- BioMonitor
- Where
- Germany
- Volunteers
- 152 people
- Sponsor
- Biotronik SE & Co. KG
Coma, Heart Arrest
Predictive Outcome in Comatose Patients
Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers…
- Conditions
- Coma, Heart Arrest, Cardiopulmonary Resuscitation
- Trial name
- PRECOM (NCT05321459)
- Testing
- Neurological prognosis
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Disorders of Consciousness
Diagnosis Value of Interoceptive EEG Indicators by Rectal Stimulation in DoC
Study on the Significance and Value of Interoception-Related Indicators in the Classification of Patients with Disorders of Consciousness (DoC) via Rectal Stimulation
- Trial name
- NCT07208942
- Testing
- Rectal Stimulation
- Where
- 2 sites in China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- YiLin Zhao
Syncope
International Study on Syncope of Uncertain Etiology
This is a multi-center, prospective, observational study enrolling 400 patients with suspected or certain neurally-mediated syncope, who undergo carotid sinus massage, tilt testing and Implantable Loop Recorder (ILR)implantation.
- Trial name
- NCT00120094
- Where
- 3 sites in Italy, United Kingdom
- Volunteers
- 400 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Pain, Opioid Use
Nociception-Level (NOL) for the Assessment of Pain in Patient Unable to Self-Report
In this study we aimed to investigate the performance and effectiveness of NOL and/or NOLedge as a tool for pain assessment in geriatric and critical ill non communicating patients.
- Conditions
- Pain, Opioid Use, Dementia, Unconscious
- Trial name
- MoNOLog (NCT04581642)
- Testing
- PMD200
- Where
- Israel
- Volunteers
- 33 people
- Sponsor
- Medasense Biometrics Ltd
Reflex Syncope
Cardioinhibitory Reflex Syncope. Permanent Pacemaker Therapy or Cardioneuroablation?
Reflex syncope is the most common form of syncope. It can lead to injuries and affect quality of life. Nonpharmacological and medical therapies have limited effectiveness.
- Trial name
- PANACEA (NCT05855603)
- Testing
- Cardioneuroablation, Permanent pacemaker therapy
- Where
- 10 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge