Clinical trials: Diseases Category
Obesity
Responses to Appetite and Taste in the Brain Circuits That Control Eating Behaviour
The aim of this study is to gain insight into brain structure and the neural networks that control taste and eating behaviour in patients with severe obesity undergoing a primary sleeve gastrectomy (SG) or a lifestyle…
- Trial name
- TASTER (NCT03547063)
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University College, London
Oral Intake, Dysphagia
Screening the Patient for Oral Intake: Applicability of the Yale Swallow Protocol in Patients Across Disease Categories
With 98 swallow screening tools already developed, dysphagia remains under-screened and undiagnosed. Even for patients at high risk of oropharyngeal dysphagia (i.e., hospitalized aged, post-stroke, Parkinson's disease, head and…
- Conditions
- Oral Intake, Dysphagia, Swallow Difficulty
- Trial name
- NCT06171165
- Testing
- Yale Swallow Protocol
- Where
- Taiwan
- Volunteers
- 502 people
- Sponsor
- National Taiwan University Hospital
Diabetic Foot Ulcer
Clinical Study to Compare Two Skin Substitute Categories for Their Effectiveness to Treat Diabetic Foot Ulcers
The purpose of this clinical evaluation is to collect patient outcome data on a commercially available 510K FDA cleared advanced skin substitute. The commercially available product is Helicoll® Advanced Skin Substitute.
- Trial name
- NCT06557122
- Testing
- SOC and Advanced Bioengineered Skin Substitute, SOC and Active Comparator
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Encoll Corp
Alcoholism, Substance Abuse
Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence in Adolescent
ASSIST mini-intervention is applied in an electric form in adolescent outpatients to see if it
- Conditions
- Alcoholism, Substance Abuse, Alcohol Dependence, Alcohol-Related Disorders
- Trial name
- REAL-SMART (NCT06262958)
- Testing
- ASSIST, Treatment as usual
- Where
- Finland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM)
The Efficacy and Safety of REX-001 to Treat Ischemic Rest Pain in Subjects With CLI Rutherford Category 4 and DM
This trial is a pivotal, placebo-controlled, double-blind, parallel-group, adaptive trial conducted in subjects with DM and CLI Rutherford Category 4.
- Conditions
- Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM), Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT03111238
- Testing
- REX-001
- Where
- 15 sites in Czechia, Germany and 4 more
- Volunteers
- 3 people
- Sponsor
- Ixaka Ltd
Critical Limb Ischemia
Study to Explore the Effect of Lowering Blood Viscosity in Patients With Treatment-resistant Critical Limb Ischemia
PAD is caused by an increased flow resistance in atherosclerotic ischemic limbs. The investigators hypothesize that reducing blood viscosity (through controlled phlebotomy), thereby increasing the deformability of red blood…
- Trial name
- CLI-PH (NCT01758874)
- Testing
- phlebotomy
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul Veterans Hospital
Diet Records, Caloric Restriction
A New Method for Self-assessment of Daily Calorie Intake
The purpose of this study is to assess the validity of self-caloric evaluation, the "categories method" - a new method based on one categorical score per meal
- Trial name
- NCT01408784
- Where
- Israel
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Lymphoma, Hodgkin Lymphoma (Category)
Rituximab in Treating Patients With Hodgkin's Lymphoma
Phase 2 trial to study the effectiveness of rituximab in treating patients who have lymphocyte-predominant Hodgkin's lymphoma.
- Conditions
- Lymphoma, Hodgkin Lymphoma (Category), Nodular Lymphocyte Predominant Hodgkin Lymphoma
- Trial name
- NCT00003820
- Testing
- Rituximab
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Ranjana Advani
Thyroid Nodule
The Application Value of Deep Learning-Based Nomograms in Benign-Malignant Discrimination of TI-RADS Category 4 Thyroid Nodules
This retrospective study focuses on benign and malignant classification of thyroid nodules using deep learning techniques and evaluates the value of deep learning based nomograms in the classification of TI-RADS category 4…
- Trial name
- NCT06258044
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ma Zhe
Early Gastric Cancer
A Clinical Trial to Evaluate the Sensitivity and Specificity of "WAYMED Endo" Compared to the Endoscopists in Classifying Early Gastric Cancer (EGC) Based on the Depth of Invasion in Endoscopic Images
The purpose of this clinical trial is to prove that the prediction capability of 'WAYMED endo' is superior to that of the endoscopists in classifying EGC based on the depth of invasion categories in gastro-endoscopic images.
- Trial name
- NCT06317103
- Testing
- WADYMED endo, Control group (the endoscopists)
- Where
- South Korea
- Volunteers
- 653 people
- Sponsor
- WAYCEN Inc
Glioblastoma, Gliosarcoma, Adult
A Study Assessing if it is Safe and Possible to Treat Brain Cancer Patients With Immunotherapy Before They Receive the Standard Treatment.
WinGlio is a phase I study investigating neoadjuvant (before surgery) ipilimumab ( a type of immunotherapy drug) in patients with newly diagnosed glioblastoma (a form of brain cancer).
- Conditions
- Glioblastoma, Gliosarcoma, Adult, Glioblastoma - Category
- Trial name
- WinGlio-ipi (NCT07134842)
- Testing
- Ipilimumab (3 mg/kg)
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University College, London
Neurological Outcome, Cardiac Arrest
Out-of-hospital Cardiac Arrest (OHCA) Biomarkers
Few early prognostic indicators are currently available for patients' families and clinicians following out of hospital cardiac arrest (OHCA), and blood biomarkers may be of prognostic value in these cases.
- Conditions
- Neurological Outcome, Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Brain Anoxia Ischemia
- Trial name
- NCT03112486
- Testing
- blood draw
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cadmium Exceeds the Standard
Study on Neuropsychiatric Behavior in Cadmium-exposed People
This study hypothesized that excessive cadmium is related to clinical pain, depression, and cognitive impairment, and that related indicators will improve after cadmium is eliminated.
- Trial name
- NCT06572566
- Testing
- Non-invasive examination and assessment.
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Jianersheng (Zhuhai) Pharmaceutical Technology Co., Ltd.
Skin Laceration, Skin Abrasion
Retrospective, Observationnal Study to Investigate Procedural Analgesia Delivered to Patients With Lacerations, Abrasions, Burns and Leg Ulcers.
The main part of the study is a retrospective analysis of 200 reports concerning patients with skin wounds and injuries : 50 consecutive patient reports dealing with skin lacerations 50 consecutive patient reports dealing with…
- Conditions
- Skin Laceration, Skin Abrasion, Skin Burn, Leg Ulcer
- Trial name
- APPABU (NCT07350811)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Versailles Hospital
Developmental Language Disorder, Adults Without Language Disorder
Category Learning Retention in Adults With and Without Developmental Language Disorder
Approximately 7% of the population experiences developmental language disorder (DLD), a language disorder with unclear causes. DLD affects communication beyond adolescence and poses challenges for education and career advancement…
- Trial name
- Time2Learn (NCT05901493)
- Testing
- Perceptual category training
- Where
- 2 sites in United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- University of Delaware
AML, ALL
Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders
Allogeneic stem cell transplantation may provide long-term remissions for some patients with hematological malignancies. However, allogeneic transplantation is associated with a significant risk of potentially life threatening…
- Conditions
- AML, ALL, CLL, Myelodysplastic Syndrome
- Trial name
- NCT00533923
- Testing
- Cyclophosphamide; Fludarabine; Cyclosporin; CAMPATH-1H (Alemtuzumab); GM-CSF
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Colorectal Cancer Screening
Validation of Advanced Colorectal Neoplasm Risk Categories in a Prospective Cohort in Mexico
Worldwide, there are 1,361,000 new cases of colorectal cancers (CRC) annually, with 694,000 deaths. However, the incidence varies by up to a factor of 10x between high and low incidence countries (eg.
- Trial name
- COLOFIT (NCT05661292)
- Testing
- Fecal inmunochemical test, Colonoscopy, Optional collection of tissue, blood and urine for future biomedical research
- Where
- Mexico
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Age-related Macular Degeneration (AMD)
Intervention Trial in Early Age-related Macular Degeneration
The purpose of the I-TEAM project is to assess whether there is a change in visual function and status of the retina after a year of intervention in subjects with early signs of Age-related Macular Degeneration.
- Trial name
- I-TEAM (NCT01694680)
- Testing
- Lutein-enriched-egg beverage (NWT-02)
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- Newtricious R&D BV
Diabetes Mellitus, Type 2
An Open Study to Evaluate Whether Pack Size Affects Compliance of Metformin Treatment in Subjects With Type II Diabetes
MTF116086 is an open-label, randomised, parallel-design study in subjects with type II diabetes. The study is site-based, with local pharmacies serving as the sites and pharmacists as principal investigators for the sites.
- Trial name
- NCT01817777
- Testing
- Metformin Small Pack, Metformin Large Pack
- Where
- 7 sites in Argentina
- Volunteers
- 31 people
- Sponsor
- GlaxoSmithKline
Enthesitis-related Arthritis (ERA), Juvenile Psoriatic Arthritis (JPsA)
Long Term Treatment Strategies and Effectiveness of Secukinumab in Patient With JIA Subtypes of JPsA and ERA: Study From German BIKER Registry.
The goal of this study is to understand the long-term treatment strategies in children and adolescents diagnosed with ERA or JPsA who received secukinumab and achieved inactive disease and to evaluate the long-term treatment…
- Trial name
- NCT07190053
- Testing
- Secukinumab
- Volunteers
- 100 people
- Sponsor
- Novartis Pharmaceuticals