Clinical trials: Disease Burden
Cerebrovascular Disease
Quality of Life of Stable Stroke Survivors in Pakistan
In study the investigators sought to 1. Assess the quality of life experience in stable post stroke survivors in Pakistan and detail important factors influencing quality of life. 2.
- Trial name
- NCT02351778
- Volunteers
- 350 people
- Sponsor
- Aga Khan University
Acute Coronary Syndrome
MDCO-216 Infusions Leading to Changes in Atherosclerosis: A Novel Therapy in Development to Improve Cardiovascular Outcomes - Proof of Concept Intravascular Ultrasound (IVUS), Lipids, and Other Surrogate Biomarkers Trial
This study will be a proof-of-concept, placebo-controlled, double-blind, randomized trial in participants with a recent acute coronary syndrome (ACS) to evaluate the efficacy, pharmacokinetics, safety, tolerability, disease…
- Trial name
- PILOT (NCT02678923)
- Testing
- MDCO-216
- Where
- 20 sites in Canada, Czechia and 3 more
- Volunteers
- 126 people
- Sponsor
- The Medicines Company
Coronary Artery Disease, Hypercholesterolemia
A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma
The main aim of this trial is to demonstrate that Evolocumab plus routine lipid management is superior to routine lipid management alone in modifying plaque (non-calcified) volume as measured by Artificial Intelligence-enabled…
- Conditions
- Coronary Artery Disease, Hypercholesterolemia, Atheroma, Atherosclerotic Plaque
- Trial name
- NCT07803679
- Testing
- Evolocumab, Routine Lipid Management, Autoinjector
- Volunteers
- 308 people
- Sponsor
- Amgen
Burden, Caregiver
Social Support and Stress Reduction for Caregivers of Young Adults With IDD
The objective of this study is to evaluate the feasibility and stress reduction impacts of a yoga and support group intervention on caregivers of individuals with intellectual and developmental disabilities.
- Trial name
- CareWell (NCT05938998)
- Testing
- Yoga; Support Group
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
RSV Acute Respiratory Infection
Disease Burden of RSV
Respiratory diseases are one of the leading causes of morbidity and mortality among young children, and respiratory syncytial virus (RSV) is the most common pathogen causing these respiratory diseases in this age group.
- Trial name
- RSV ComNet III (NCT05506670)
- Testing
- Diagnostic test and phone call, Diagnostic test
- Where
- 5 sites in France
- Volunteers
- 84 people
- Sponsor
- Hospices Civils de Lyon
Caregiver Burden, Mental Health Issue
Effectiveness of Positive Psychotherapy on Mental Wellbeing Among Caregivers of Cerebral Palsy Children
The Central idea of the proposed research proposal is first to translate adapt and validate the Caregiver Difficulties Scale \& Positive Psychotherapy sessions based manual into Urdu language then secondly, assessment of burnout…
- Conditions
- Caregiver Burden, Mental Health Issue, Cerebral Palsy
- Trial name
- NCT05613595
- Testing
- Positive Psychotherapy, Counseling Group
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- International Islamic University, Islamabad
Coronary Artery Disease
Intravascular Ultrasound Prediction of Myocardial Size and Coronary Computed Tomography-Derived Ischemic Burden for Coronary Lesion
The aims of this study are 1) to identify IVUS determinants of the CAMS-derived myocardial territories subtended to the diseased vessels, 2) to find IVUS determinant for the extent of CAMS-derived myocardial size, and 3) to…
- Trial name
- IVUS-CAMS (NCT02845505)
- Testing
- Intravascular Ultrasound, coronary computed tomography angiography
- Where
- 12 sites in South Korea
- Volunteers
- 500 people
- Sponsor
- Asan Medical Center
Autism Spectrum Disorder, Insomnia Chronic
Treatment to Improve Sleep in Caregivers With Insomnia and a Child With Autism
Autism Spectrum Disorder (ASD) represents one of the most perplexing neurobiological disorders with a prevalence of 1 in 54 children.
- Conditions
- Autism Spectrum Disorder, Insomnia Chronic, Caregiver Burden
- Trial name
- NCT05373537
- Testing
- Cognitive behavioral therapy for Insomnia
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alzheimer's Disease
A Study to Show That the Change of Attention Measure is Correlated With the Changes of Caregiver's Burden After Treatment With Galantamine in Patients With Alzheimer's Disease
The purpose of this study is to demonstrate that the change of attention measure is correlated with the changes of caregiver's burden after treatment with galantamine.
- Trial name
- NCT01734395
- Testing
- Galantamine
- Volunteers
- 1,882 people
- Sponsor
- Janssen Korea, Ltd., Korea
Carotid Stenosis, Carotid Artery Diseases
Cerebral Oximetry During Awake Carotid Endarterectomy
Surgery to remove plaque from the carotid artery in the neck requires the artery to be clamped for a period of time. In some patients this reduces blood flow to the brain enough to cause temporary symptoms, and a temporary…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Brain Ischemia, Carotid Endarterectomy
- Trial name
- COACE (NCT07816081)
- Testing
- Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- Nguyen Toan Thang
Disability or Chronic Disease Leading to Disablement
Risk Factors Associated With the Global Burden of Disease in Reunion Island and Comparison With Mainland France and Indian Ocean Countries
The question posed by this project is that of the regional estimate of the relative importance of the risk factors of the main pathologies.
- Trial name
- AVIRON-2 (NCT03357302)
- Where
- France
- Volunteers
- 100,000 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Kidney Stones
Durability of Flexible Ureteroscopes and Causes of Infection During Flexible Ureterorenoscopy
This is an observational study in which data on consecutive patients who undergo ureterorenoscopy with the use of a flexible ureterorenoscope are collected.
- Trial name
- NCT03087812
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Clinical Research Office of the Endourological Society
Breast Cancer, Axillary Lymph Node Metastasis
Ultrasound Radiomics for Predicting Breast Cancer and Axillary Lymph Node Metastasis
The project is proposed based on multimodal ultrasonic imaging omics building used for accurate prediction of the breast cancer and axillary lymph node metastasis load artificial intelligence forecasting model, this method can…
- Trial name
- NCT05768451
- Testing
- Ultrasonic image analysis
- Volunteers
- 200 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Atrial Fibrillation (AF), Digital Health Intervention
Burden-Evaluated Active Therapy for AF Using Continuous Wearables BEAT-AF Trial
Traditional AF classification (e.g., paroxysmal, persistent, permanent) relies largely on patient-reported symptoms and intermittent electrocardiographic monitoring, which cannot continuously or objectively reflect disease…
- Conditions
- Atrial Fibrillation (AF), Digital Health Intervention, Wearable Monitoring
- Trial name
- NCT07512037
- Testing
- 5D-AF Burden-Guided Active Management
- Where
- China
- Volunteers
- 3,194 people
- Sponsor
- Navy General Hospital, Beijing
Gorlin Syndrome
Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome
The aim of this clinical study is to find out how well Patidegib Gel 2% works in preventing new basal cell carcinomas (BCCs) developing on the face of adults with Gorlin syndrome, and how safe Patidegib Gel 2% is to use.
- Trial name
- NCT06050122
- Testing
- Patidegib Topical Gel, Patidegib Topical Gel with no active patidegib
- Where
- 40 sites in United States, France and 5 more
- Volunteers
- 113 people
- Sponsor
- Sol-Gel Technologies, Ltd.
Menopause, Perimenopausal Disorder
Virtual perI-/Menopause Registry of AusTrALia
13 million (50.7%) Australians are born with ovaries, 14% (~3 million) are currently aged 40-59 yrs, \& all such who live to midlife will experience menopause, defined as >12 months without a period.
- Conditions
- Menopause, Perimenopausal Disorder, Postmenopausal Symptoms, Health Knowledge, Attitudes, Practice
- Trial name
- VITAL (NCT06487130)
- Testing
- N/A Observational Registry
- Where
- Australia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Bespoke Clinical Research
RSV Infection, Children, Only
RSV Burden in Outpatient and Hospital Settings
Strengthening outpatient low respiratory tract infection surveillance to document the burden of Respiratory Syncytial Virus (RSV)
- Conditions
- RSV Infection, Children, Only, Outpatient, Otitis
- Trial name
- Oursyn (NCT04743609)
- Testing
- nasopharyngeal samples
- Where
- France
- Volunteers
- 1,900 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Atrial Fibrillation, Persistent
First-line Cryoablation for Early Treatment of Persistent Atrial Fibrillation
The goal of this multicentre, prospective, randomized, open, blinded for evaluation of end point (PROBE) controlled parallel-group superiority trial, is to compare the efficacy of antiarrhythmic drug (AAD) therapy and cryoballoon…
- Trial name
- NCT05939076
- Testing
- Pulmonary vein isolation, dronedarone - Multaq™ OR flecainide - Tambocor™ OR propafenone - Rytmonorm™ OR sotalol - Sotacor™
- Where
- 6 sites in Hungary, Slovakia and 2 more
- Volunteers
- 220 people
- Sponsor
- Region Örebro County
Arthropathy of Knee, Pain, Joint
Assessing if Cryoneurolysis Improves Prehabilitation and Decreases Pain After Surgery With Less Opioid Use in TKA Patients
This is a prospective, randomized control trial to evaluate the impacts of preoperative cryoneurolysis treatment on opioid consumption with prehabilitation and resulting postoperative functional improvement in patients undergoing…
- Conditions
- Arthropathy of Knee, Pain, Joint, Arthritis Knee, Opioid Use
- Trial name
- NCT03836313
- Testing
- iovera°
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Autism, Parenting
The Effects of an Empowerment Program for Parents of Children With Autism
This study aims to evaluate the effectiveness of an empowerment program that includes both parent training and motivational interviewing for parents of children with autism, supporting their competence in the care of their…
- Conditions
- Autism, Parenting, Motivational Interviewing
- Trial name
- NCT06629974
- Testing
- Parental empowerment program
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Manisa Celal Bayar University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.