Clinical trials: Discomfort
Visual Fatigue
Visual Discomfort and Reading
Reading can be an uncomfortable and difficult task for some people. Symptoms include unpleasant somatic and perceptual effects, such as eye-strain, headache, and blurred text, despite normal visual acuity.
- Trial name
- NCT00402155
- Testing
- Stress on visual discomfort
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Stridor
Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children
The study aims to analyze and compare the clinical effects of using inhaled budesonide or intravenous dexamethasone in the treatment of postextubation stridor on children admitted to the pediatric intensive care units at Hospital…
- Trial name
- BUDEXA (NCT02056379)
- Testing
- Budesonide, Dexamethasone
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Hospital Israelita Albert Einstein
Advanced Lung Cancer
A Clinical Study of Pain and Discomfort Associated With Advanced Lung Cancer
In this research, the patients with advanced lung cancer accompanied by pain and discomfort were treated by injecting freshly manufactured tissue permeable hyaluronan fragment HA35 into the tissue under abdominal adipose.
- Trial name
- NCT05852002
- Testing
- 35 kDa hyaluronan fragment
- Where
- Mongolia
- Volunteers
- 10 people
- Sponsor
- Nakhia Impex LLC
Evaluate Patient Comfort Level During Paracentesis by Numbing Skin With a Needle-less Device, Instead of Using a Needle to Numb the Skin
J-Tip Use for Paracentesis in Adults With Ascites
The purpose of this clinical trial is to evaluate the level of comfort adult patients with cirrhosis of the liver and ascites presenting to Northwestern Memorial Hospital experience during a bedside abdominal paracentesis by…
- Trial name
- NCT06996379
- Testing
- Experimental J-Tip Needle-Free Injection System, Control (Standard treatment)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Northwestern University
Knee Injuries, Cartilage Injury
Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee
Multi-center, prospective, concurrently controlled, non-randomized, double-blind (patient and assessor). Treatment of large chondral lesions in the knee with microfracture plus the Chondro-Gide® ACC is non-inferior to treatment…
- Conditions
- Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
- Trial name
- SECURE (NCT04537013)
- Testing
- Microfracture, Microfracture plus placement of Chondro-Gide® ACC
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 82 people
- Sponsor
- Geistlich Pharma AG
Blood Flow Restriction (BFR) Training Effects, Arterial Stiffness, Blood Pressure
Effect of Limb Occlusion Pressure Attainment on Cardiovascular, Perceptual, and Performance Responses
To test the effect of limb occlusion pressure attainment in the supine, seated, and standing position on exercise performance, vascular physiology, and muscle.
- Conditions
- Blood Flow Restriction (BFR) Training Effects, Arterial Stiffness, Blood Pressure, Muscle Morphology, Perceptions
- Trial name
- NCT06718582
- Testing
- Delfi Training Device
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Teri Herberger
Ocular Discomfort
A Study to Evaluate the Clinical Performance of a Novel Multipurpose Solution
The objective of this study is to evaluate the clinical performance of Bausch \& Lomb investigational Multi-Purpose Solution compared to Ciba Vision Multi-Purpose Solution when used by wearers of silicone hydrogel or Group IV…
- Trial name
- NCT01024751
- Testing
- Bausch & Lomb Multi-Purpose Solution, Ciba's Multi-Purpose Solution
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye Syndromes
Evaluation of Dry Eye Disease's Signs in Patients Who Were Administered Intravitreal Anti-VEGF Injections
The goal of this interventional, monocentric, prospective, single-masked, case-control study is to evaluate the efficacy of Thealoz Duo (artificial tear containing trehalose 3 g and hyaluronic acid 0.15 g) in comparison to a…
- Trial name
- DRYEYE-IVT (NCT06317922)
- Testing
- Thealoz Duo;
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Francesco Bandello
Pain, Postoperative
Efficacy of Sacral Erector Spinae Plane Block (SESPB) on Postoperative Pain and Catheter-related Bladder Discomfort
The goal of this clinical trial is to evaluate the catheter related bladder discomfort in patients who will undergoing TUR-P operation.
- Trial name
- SESPB (NCT06127394)
- Testing
- Sacral ESP Block, Pudendal Block
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Giresun University
Dental Anxiety
Digital Versus Conventional Impression on Discomfort and Dental Anxiety Among Preschoolers
Background: Taking alginate impressions for preschoolers is challenging and might be disturbing for them. Therefore, intraoral scanners are suggested as a better alternative to the conventional alginate impression.
- Trial name
- NCT06623851
- Testing
- Intraoral scanner, Alginate impression
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Hams Hamed Abdelrahman
General Wellbeing, Gastrointestinal Health
Hemp Oil + User Experience Study
Presented as an online survey, this study seeks to better understand how Thorne customers are using and experiencing the new Hemp Oil + product and how they feel it compares in the marketplace.
- Conditions
- General Wellbeing, Gastrointestinal Health, Physical Discomfort, Sleep
- Trial name
- NCT04026672
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Thorne HealthTech, Inc
Gastric Cancer
Gastric Decompression After Sub-total Gastrectomy
The purpose of this study is to test the utility of the nasogastric tube, which is used to decompress and as "guardian" of gastro-jejunal anastomosis, in patients undergoing distal subtotal gastrectomy for gastric cancer with…
- Trial name
- NCT01073046
- Testing
- Naso-Gastric/Jejunal Tube
- Where
- Italy
- Volunteers
- 276 people
- Sponsor
- Catholic University, Italy
Healthy
Effects of Kilohertz-frequency and Low-frequency Current on Triceps Surae
Neuromuscular electrical Stimulation (NMES) can minimize muscle atrophy and complications related to muscle disuse and help improve neuromuscular performance.
- Trial name
- NCT05894044
- Testing
- Russian current 10%, Aussie current 10%, Pulsed current 500 µs phase
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Postoperative Pain
Postoperative Discomfort After Dental General Anesthesia
The aim of this prospective, randomised, controlled clinical trial was to compare immediate postoperative discomfort, emergence delirium and recovery time of the patients intubated using either laryngeal mask airway or…
- Trial name
- NCT03197753
- Testing
- Laryngeal mask airway, Nasotracheal intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Work-Related Condition, Menstrual Discomfort
Increase Health Literacy Through Health Education to Improve Menstruation Related Self-care and Work Productivity
The aim of the study is to increase health literacy, especially in menstruation self-care, and empower female RMG workers through health education by an occupational nurse, and as a consequent improve work productivity in RMG…
- Conditions
- Work-Related Condition, Menstrual Discomfort, Occupational Problems
- Trial name
- NCT05886101
- Testing
- Health Education
- Where
- Bangladesh
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Diagnostic Esophagogastroduodenoscopy
Premedication With Alprazolam and Midazolam for Upper Gastrointestinal Endoscopy
Diagnostic upper GI endoscopy can be uncomfortable and stressful for many patients. Various methods are available for sedation during this procedure.
- Trial name
- NCT03130842
- Testing
- Sublingual alprazolam, Oral midazolam
- Where
- Iran
- Volunteers
- 136 people
- Sponsor
- Isfahan University of Medical Sciences
Dry Eye
Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK
Collecting data using Kera Sol tear usage during the initial two-week post-operative period after Laser-Assisted In Situ Keratomileusis (LASIK) has on the signs and symptoms of surgical temporary ocular discomfort syndrome (STODS)
- Trial name
- NCT07155070
- Testing
- Kera Sol Eye Drops
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Urinary Catheters, Bladder Pain and Discomfort
FLUME Catheter Comfort Study
The Flume catheter is a commercially available (FDA 510(k) cleared) urethral catheter with an innovative catheter design. The traditional Foley catheter design includes a protruding tip with drainage holes.
- Conditions
- Urinary Catheters, Bladder Pain and Discomfort, Urine Leakage, Bladder Spasm
- Trial name
- NCT05785858
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- The Flume Catheter Company Ltd
Plaque, Dental
Efficacy of a Eugenol-based Product to Improve the Quality of Toothbrushing and Relieving Gum Discomfort Areas
The objective of this study is to evaluate the efficacy of a eugenol-based product in improving the quality of toothbrushing and relieving areas of gingival discomfort.
- Trial name
- NCT06366568
- Testing
- fluoride toothpaste containing 1450 ppm of MFP in a PCC base and eugenol gum product, fluoride toothpaste containing 1450 ppm of MFP in a PCC base
- Where
- Germany
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Refractory Cancer Pain, Intrathecal Analgesia
Intrathecal Analgesia Effects on Cancer Patients Discomfort Symptoms
Intrathecal analgesia is used in refractory cancer pain because of drug sides effects or intractable pain. The aim of this approach is to improve pain management, and also to improve patient comfort.
- Trial name
- IT-ESAS (NCT04491123)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier