Clinical trials: Dilation
Aging, Vascular Stiffness
Acetate and Age-associated Arterial Dysfunction
Cardiovascular diseases are the leading cause of morbidity and mortality and contribute most to healthcare costs in the U.S. Age is the strongest cardiovascular disease risk factor, with >90% of all deaths from cardiovascular…
- Conditions
- Aging, Vascular Stiffness, Vascular Dilation
- Trial name
- NCT05424263
- Testing
- Calcium Acetate Oral Solution, Calcium Carbonate Oral Suspension
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy
Acute Strawberry Intake on Endothelial Function
The primary objectives of the study are (1) to evaluate the effects of acute dietary strawberry intake on measures of vascular function in healthy adults following a meal challenge, (2) to evaluate the effects of acute dietary…
- Trial name
- SFMD (NCT03596008)
- Testing
- Active drink
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
Non-Invasive Evaluation of Myocardial Stiffness by Elastography in Pediatric Cardiology (Elasto-Pédiatrie)
First, investigators must determine the physiological standards across age classes of myocardial stiffness estimated by Elastography in ultrafast (estimated right ventricular stiffness [VD] and left ventricular [LV]).
- Trial name
- NCT02619825
- Testing
- Echography, Elastography
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Nitrate, Caffeine
The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function.
Dietary inorganic nitrate supplementation may have positive implications on cardiovascular function. The aim of this project is to determine if nitrate supplementation can attenuate the effects that caffeine and cold exposure…
- Conditions
- Nitrate, Caffeine, Cold Exposure
- Trial name
- NCT06602921
- Testing
- TruBeet inorganic beetroot juice, Caffeine, Cold pressor test
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Dilated Cardiomyopathy
Exercise Stress MRI to Evaluate Aortic Function (Compliance, Distensibility, Pulse Wave Velocity) and Left Ventricular Function : Validation in Healthy Volunteers and in Selected Patients. A Pilot Study.
Detecting abnormalities in the left ventricular mechanical and hemodynamic response to the stress of exercise may offer early diagnostic indicators in patients suffering from valvular disease such as mitral regurgitation.
- Trial name
- NCT02018835
- Testing
- MRI, cardiac echography transthoracic
- Where
- France
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pre Diabetes, Vascular Stiffness
Dietary Exchanges With Avocado and Mango in Pre-diabetes
The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals…
- Conditions
- Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change
- Trial name
- AVMa (NCT05353790)
- Testing
- Meals + snacks: control, Meals + snacks: Avocado mango
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Pregnancy
Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation
Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus.
- Trial name
- NCT03315806
- Testing
- Beetroot juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Vascular Stiffness, Endothelial Dysfunction
Targeting Inflammation to Treat Cardiovascular Aging
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States with older age being a primary risk factor.
- Conditions
- Vascular Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- TIVA (NCT01775865)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Cystic Fibrosis
Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF
This project is an attempt to understand how Orkambi treatment affects exercise capacity and the function of the arteries in CF patients who are homozygous F508del.
- Trial name
- NCT03338595
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Augusta University
Abortion, Dilation and Evacuation
Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation
Prophylactic tranexamic acid has shown been shown to reduce maternal mortality from postpartum hemorrhage with no adverse effects, but has not been studied to reduce bleeding complications with dilation and evacuation (D\&E).
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Blood Loss
- Trial name
- NCT04651166
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Induced; Birth, Cervical Dilatation
Induction to Labour With Double Cervical Ballon at Home Versus at Hospital
The goal of this clinical trial] is to compare the outcomes between induction to labour at home versus hospitalized. The main questions it aims to answer are: Can the induction to labour at home with cervical rippening ballon…
- Conditions
- Induced; Birth, Cervical Dilatation, Live Birth
- Trial name
- INDOBAMHOS (NCT06053073)
- Testing
- Cervical rippening at home, Cervical rippening in the hospital
- Where
- Spain
- Volunteers
- 834 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiovascular Diseases, Vascular Dilation
Chardonnay Marc and Vascular Response
This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health.
- Conditions
- Cardiovascular Diseases, Vascular Dilation, Oxidative Stress
- Trial name
- NCT05545865
- Testing
- Low Flavanol Cocoa Powder, High Flavanol Cocoa Powder, Vine to Bar Chocolate - 2 servings
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Venous Distension Reflex, Blood Pressure
Autonomic Control of the Circulation and VDR
The study objective of this project is to examine the mechanisms of the venous distension reflex (VDR) in humans. We hypothesize that COX blockade with ketorolac tromethamine, an intravenous NSAID, will attenuate the muscle…
- Trial name
- VDR (NCT03513770)
- Testing
- Wrist-to-elbow (W-E) occlusion, ketorolac tromethamine, saline control
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Eye Disease, Eye Care
Tailored Messages to Increase Eye Examination Behavior
The purpose of this project is to test two different types of health messages, one that is developed for a specific group (targeted) and the other that is more personalized to individuals (tailored), to see which is better at…
- Trial name
- NCT00649766
- Testing
- tailored newsletter, targeted newsletter
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Rheumatoid Arthritis, Lymph Node Mass
Relationship Between the Activity of Rheumatoid Arthritis and Lymph Node Morphology and Lymphatics Drainage
To observe the relationship between the activity of rheumatoid arthritis and popliteal/epitrochlear lymph node morphology and the drainage of hand/foot superficial lymphatic vessels
- Conditions
- Rheumatoid Arthritis, Lymph Node Mass, Lymphatic Vessel; Dilatation
- Trial name
- NCT02876874
- Testing
- indocyanine green(ICG)
- Where
- 2 sites in China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Chronic Airway Disease
Impulse Oscillation to Evaluate Diagnostic Efficacy in Patients With Chronic Airway Disease
The aim of the research is to explore the diagnostic efficacy of impulse oscillation (IOS) before and after bronchial provocation test (BPT) and bronchial dilation test (BDT) in chronic airway disease.
- Trial name
- NCT04668027
- Testing
- impulse oscillation（IOS）, bronchial provocation test(BPT), bronchial dilation test(BDT)
- Where
- China
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Assessment, Self, Simulation-Based Education
Brief Title: Portable 3D Visual Material-Supported Simulation Training for Cervical Dilation Assessment
This randomized controlled trial aimed to evaluate the effectiveness of simulation-based education supported by a portable and mobile three-dimensional (3D) visual material on university students' knowledge of cervical dilation…
- Trial name
- NCT07705503
- Testing
- Portable 3D Visual Material-Supported Simulation Training, Standard Education
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Marmara University
Dilatation of Cranial Arteries; MMA, STA and MCA, Headache
The Effect of Levcromakalim Infusion on the Cranial Arteries Over Several Hours Using a High Resolution MRA Technique in a Randomized, Double-blind Placebo-controlled Design in Healthy Volunteers.
Healthy participants vill randomly be allocated in a 2:1 order to receive 1 mg levcromakalim or placebo (isotonic saline) for 20 min.
- Trial name
- NCT03609008
- Testing
- Levcromakalim, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Healthy Subjects
The Effect of Inhibitory Control Processes Induced by Rectal Distension on Impulse Control Measured by Stroop Task Performance and Intertemporal Discounting.
The aim of this study will be to investigate the effect of rectal distension, controlled by electronic barostat, on cognitive control ability in healthy subjects.
- Trial name
- NCT02043561
- Testing
- induction of urge by rectal distension
- Where
- Belgium
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adhesive Capsulitis
AI-Assisted Ultrasound Therapy for Adhesive Capsulitis
This study aims to integrate artificial intelligence with ultrasound imaging to investigate the dynamic biomechanical characteristics of adhesive capsulitis and to compare the therapeutic effectiveness of three ultrasound-guided…
- Trial name
- NCT07599059
- Testing
- Dual-Target Injection, Rotator Interval Injection, Posterior Recess Injection
- Where
- Taiwan
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital