Clinical trials: Diffusion MRI
Breast Cancer, Breast Diseases
Advanced Diffusion Tensor MRI for Breast Cancer
The purpose of this research is to evaluate the accuracy of the BIT-Motion (Breast Imaging Tensor-Motion) software with non-contrast MRI scanning to detect breast cancer.
- Trial name
- NCT04774471
- Testing
- Evaluation of BIT-Motion software
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Hydrocephalus, Normal Pressure Hydrocephalus
The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH
The goal of this observational study is to evaluate the role of DTI-ALPS in the diagnostic and therapeutic management of NPH The main questions it aims to answer are: Whether the glymphatic system (GS) is actually impaired in NPH…
- Trial name
- GLINFANPH_2021 (NCT06857136)
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Stroke
Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies
To investigate the relationship between the integrity of the white matter, including the corticospinal tracts and the corpus callosum, with the recovery of lower extremity function in patients with cerebral stroke at the subacute…
- Trial name
- NCT00407628
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Aphasia, Nonfluent Aphasia
Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
The purpose of this research is to utilize functional magnetic resonance imaging (fMRI) to investigate brain reorganization for language behavior in stroke patients with aphasia.
- Conditions
- Aphasia, Nonfluent Aphasia, Stroke
- Trial name
- NCT00467103
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
CIDP (Chronic Inflammatory Demyelinating Polyradiculoneuropathy), CMT (Charcot Marie Tooth Disease)
Diffusion Tensor Imaging in Chronic Inflammatory Demyelinating Polyneuropathy (PIDC)
The main purpose of this study is to assess the clinical feasibility of diffusion tensor imaging (DTI) for the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
- Trial name
- PIDC (NCT03460951)
- Testing
- cervical MRI
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Irritable Bowel Syndrome, Ulcerative Colitis
Phenotyping IBS: Perceptions and Modulations of Visceral Sensations
The purpose of this research study is to improve the understanding of irritable bowel syndrome (IBS) and its underlying cause. The investigators will use magnetic resonance imaging (MRI) to observe differences in the brain…
- Conditions
- Irritable Bowel Syndrome, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- PMVS-P (NCT02693730)
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
MR Image Distortion Correction, Prostate Cancer
UNDISTORT Correction of Distortions in Diffusion MRI V1.0
This is a three-year project funded by a Cancer Research UK Multidisciplinary Award and brings together a team from UCL Division of Medicine, Computer Science and University College London Hospital.
- Trial name
- UNDISTORT (NCT03151512)
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University College, London
Parkinson Disease
Diagnosis of Parkinson's Disease Using Diffusion Magnetic Resonance Imaging
The hypothesis of the study is that the dopaminergic cell death located in the basal ganglia of the brain in patients with Parkinson's Disease can be detected by diffusion Magnetic Resonance Imaging, specifically by diffusion…
- Trial name
- NCT01715727
- Where
- Taiwan
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Wang . Jiun-Jie
Alzheimer's Disease
Cerebral Substrates of Prospective Memory in Young and Its Disruption in Normal Aging and in Alzheimer's Disease: A Study in Anatomical MRI, Diffusion Tensor MRI and Functional MRI
Investigators propose in this study to evaluate prospective memory (MP) in all its complexity as well as the processes, cognitive and brain, the underlying.
- Trial name
- IMPRO (NCT02522091)
- Testing
- functional brain MRI, Neuropsychology tests
- Where
- France
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Infant Development
Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques.
- Trial name
- NCT02058225
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Glymphatic Flow
MRI of Glymphatic Clearance During Anesthetic Sedation
This study is to assess the effect of dexmedetomidine anesthesia on glymphatic flow in 5 healthy human subjects as visualized by diffusion tensor MRI.
- Trial name
- NCT02768688
- Testing
- Brain connectivity and physiology, Dexmedetomidine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Myelin Integrity
Scan-rescan Reproducibility of Myelin Sensitive MRI Techniques
This study is to assess the variation in the measurements of myelin sensitive MRI techniques in both white and grey matter in the brain.
- Trial name
- NCT04673734
- Testing
- myelin sensitive MRI scan
- Where
- Switzerland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Temporal Lobe Epilepsy (TLE)
MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe Epilepsy
This works aims at evaluating the diagnostic performance of combined MRI Volumetry, Diffusion tensor imaging and Conventional MRI in lateralizing the epileptogenic focus in patients with temporal lobe epilepsy and correlate these…
- Trial name
- NCT07384351
- Testing
- MRI
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy, Major Depressive Disorder (MDD)
Neurobiological and Genomic Predictors of Relapse in Depression
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters.
- Trial name
- MDD (NCT07328373)
- Testing
- Antidepressant Medications
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Mehmet Kemal Arikan
Parkinson Disease (PD), Paralysis; Supranuclear
Progression of Striatal and Extrastriatal Degeneration in PD and PSP Patients
This longitudinal study aims to research cognitive and gait phenotypes of Parkinson's disease and Supranuclear Palsy as well as to provide markers to track diseases progression using a multi-modality approach based on 3D-gait…
- Trial name
- PARKONTHEWAY (NCT03840252)
- Testing
- 3D gait analysis, rsfMRI, Montreal Cognitive assesment (MoCA)
- Where
- Italy
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Head and Neck Cancer, Prostate Cancer
Application of High Resolution Diffusion-weighted MR Imaging Pulse Sequence in Head and Neck, and Prostate Cancers
Magnetic resonance imaging (MRI) is a diagnostic study that makes pictures of organs of the body using magnetic field and radio frequency pulses that can not be felt.
- Trial name
- NCT01535898
- Testing
- MRI scanner with sequence
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Isolated Cervical Dystonia, Complex Dystonia
Functional MRI and DTI in the Preoperative Assessment of Dystonia
The aim of this study is to evaluate the organization of the motor circuit in a group of patients suffering from dystonia compared with a group of healthy controls.
- Conditions
- Isolated Cervical Dystonia, Complex Dystonia, Spasticity
- Trial name
- IRMF-DIFF (NCT02877836)
- Testing
- magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Fetal Growth Restriction (FGR)
DIFFUSION WEIGHTED MRI FINDINGS IN FETUSES WITH AND WITHOUT FETAL GROWTH RESTRICTION
This prospective observational study aims to compare fetal brain diffusion-weighted magnetic resonance imaging (DWI) findings in fetuses with and without fetal growth restriction (FGR) and to evaluate the association between…
- Trial name
- NCT07769957
- Testing
- Diffusion-weighted fetal brain MRI
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Uterine Neoplasms
MRI and Metabolomics Biomarkers for Uterine Malignancy
The aims of this project are: (1) To establish a research platform in order to integrate multiparametric imaging and metabolomics data for uterine malignancy.
- Trial name
- EMCAMRS (NCT02528864)
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital