Clinical trials: Diffuse Systemic Sclerosis
Systemic Sclerosis (SSc), Scleroderma
Investigation of Respiratory Muscle Sarcopenia in Patients With Systemic Sclerosis
The aim of this study was to investigate respiratory muscle sarcopenia in individuals with systemic sclerosis. The main question it aims to answer is: What is the prevalence of respiratory muscle sarcopenia in patients with…
- Trial name
- NCT06598982
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Selcuk University
Raynaud's Phenomenon, Digital Ulcers
A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma
Raynaud's phenomenon (RP) associated with scleroderma is a difficult problem to treat. Many patients develop ischemic digital ulcers due to severe RP that causes considerable morbidity and adversely affects the quality of life.
- Conditions
- Raynaud's Phenomenon, Digital Ulcers, Scleroderma
- Trial name
- NCT01117298
- Testing
- Tadalafil
- Where
- 4 sites in India
- Volunteers
- 66 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Microstomia, Scleroderma
Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease
The principal objective is to measure the degree to which oral microstomia caused by sclerosing skin disease improves after treating patients with local hyaluronidase injections.
- Conditions
- Microstomia, Scleroderma, CREST Syndrome, Scleromyxedema
- Trial name
- NCT04656704
- Testing
- hyaluronidase injected intradermally
- Sponsor
- Brigham and Women's Hospital
Tai Chi
Effectiveness of Tai Chi Exercise Program in Scleroderma Patients
Because of multiple system involvement, patients with Scleroderma have complaints such as fatigue, sleep disturbances, functional limitations, skin deformations, pain, swollen hands and joint pain.
- Trial name
- NCT04214925
- Testing
- Tai Chi
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Pamukkale University
Scleroderma, Systemic Sclerosis
Evaluating Tools to Communicate Scleroderma Research Results to Patients - Trial #1
Sharing research results with patients is required by ethical regulations. Yet, most researchers do not share results from their studies with patients.
- Trial name
- SPIN-CLEAR #1 (NCT06373263)
- Testing
- Plain-language summary, Dissemination Tool (Infographic)
- Where
- Canada
- Volunteers
- 511 people
- Sponsor
- Lady Davis Institute
Lupus Nephritis, Systemic Lupus Erythematosus
US Zamto-cel Autoimmune Diseases
AID is a phase I multi-cohort study to assess the safety and tolerability of zamtocabtagene autoleucel (zamto-cel) in patients with refractory autoimmune diseases (SLE-Non renal, SLE-LN, SSc/dcSSc) after receiving standard…
- Conditions
- Lupus Nephritis, Systemic Lupus Erythematosus, Systemic Sclerosis (SSc), Diffuse Cutaneous Systemic Sclerosis
- Trial name
- NCT06708845
- Testing
- zamtocabtagene autoleucel, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Miltenyi Biomedicine GmbH
Systemic Sclerosis
Pharmacokinetics of Oral Treprostinil in Patients With Systemic Sclerosis
This study will assess the pharmacokinetic and safety profile of treprostinil following fixed and escalating doses of treprostinil diethanolamine SR tablets.
- Trial name
- DISTOL-PK (NCT00848939)
- Testing
- treprostinil diethanolamine
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- United Therapeutics
Scleroderma, Pulmonary Hypertension
Endothelial Biomarkers of Systemic Sclerosis-associated Pulmonary Hypertension
Systemic sclerosis (SSc, AKA scleroderma) is an autoimmune condition characterized by endothelial damage and progressive fibrosis of the skin and internal organs.
- Trial name
- BOSS-PH (NCT03459716)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Lung Diseases, Interstitial
A Trial of Tadalafil in Interstitial Lung Disease of Scleroderma
Systemic sclerosis (SSc, scleroderma) is a multisystem autoimmune rheumatic disease that causes inflammation, vascular damage and fibrosis. Besides involvement of skin, fibrosis also affects lung and heart.
- Trial name
- NCT01553981
- Testing
- Tadalafil
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Scleroderma
Elastography Ultrasound in Localized Scleroderma (Morphea) Study
Localized scleroderma (LS) is a skin disease that can cause complications such as disfigurement and limitation of mobility. Treatment for LS should be initiated early in the disease, as late-stage scleroderma does not respond…
- Trial name
- NCT06847750
- Testing
- Elastography Ultrasound, The Localized Scleroderma Quality of Life Instrument (LoSQI )
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
CREST Syndrome, Peripheral Vascular Disease
Exparel as a Nerve Block for Severe Hand Pain
The purpose of this study is to investigate whether the use of the study drug (Exparel) is safe and effective for treating circulation problems and pain in the hand or fingers.
- Conditions
- CREST Syndrome, Peripheral Vascular Disease, Raynaud Disease, Scleroderma, Diffuse
- Trial name
- NCT02374320
- Testing
- liposomal bupivacaine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Jose Soberon, MD
Scleroderma, Systemic Sclerosis
SPIN Self-Management Feasibility Trial
The Scleroderma Patient-centered Intervention Network (SPIN) is an organization established by researchers, health care providers, and people living with scleroderma (systemic sclerosis; SSc) from Canada, the United States…
- Trial name
- SPIN-SELF-F (NCT03914781)
- Testing
- SPIN-SELF Program
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Lady Davis Institute
Autoimmune Diseases, Ulcerative Colitis
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation.
- Conditions
- Autoimmune Diseases, Ulcerative Colitis, Multiple Sclerosis, Scleroderma
- Trial name
- NCT06587828
- Testing
- Companion blood samples with procedure
- Where
- 11 sites in United States
- Volunteers
- 238 people
- Sponsor
- TScan Therapeutics, Inc.
Autoimmune Diseases, Connective Tissue Diseases
Study of Silicone-Associated Connective Tissue Diseases
This study will examine the possible relationship between silicone implants or injections and the connective tissue diseases scleroderma and myositis.
- Conditions
- Autoimmune Diseases, Connective Tissue Diseases, Scleroderma, Circumscribed, Scleroderma, Systemic
- Trial name
- NCT00001330
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Systemic Scleroderma
Sildenafil Effect on Digital Ulcer Healing in sClerodErma SEDUCE STUDY
Digital ulcers (DUs) are an expression of the microangiopathy in patients with scleroderma (SSc). DUs lead to pain and impaired hand use. DUs remain a severe complication for many patients and effective therapy remains elusive.
- Trial name
- SEDUCE (NCT01295736)
- Testing
- Sildenafil
- Where
- 24 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Lille
Scleroderma, Systemic, Digital Ulcer
Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis
This study is performed to consider the safety and healing ability of diosmin in patients with systemic sclerosis (scleroderma) and open sores on their fingers (digital ulcers).
- Trial name
- NCT06256575
- Testing
- Diosmin
- Where
- 5 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Primus Pharmaceuticals
Systemic Sclerosis, Scleroderma
Efficacy and Tolerability of STI571 (Imatinib Mesylate) for the Treatment of Fibrosis in Participants With Systemic Sclerosis
This study investigates the efficacy and safety of STI571 for the treatment of fibrosis in participants with systemic sclerosis.
- Trial name
- NCT00613171
- Testing
- STI571
- Where
- 7 sites in United States, Germany and 3 more
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Scleroderma, Diffuse
ADRCs in The Treatment of Hand Dysfunction Due to Scleroderma
The primary objective of this study is to assess the safety and efficacy of the Celution Device in the processing of an autologous graft consisting of adipose derived regenerative cells (ADRCs) in the treatment of hand…
- Trial name
- STAR-II (NCT05148598)
- Testing
- ADRCs, Standard Care
- Volunteers
- 174 people
- Sponsor
- Paracrine, INC.
Scleroderma, Pulmonary Artery Hypertension
Cardiac Assessment by PV Loop in IPAH and Scleroderma PAH
This observational study is being done to understand why people with scleroderma can develop pulmonary arterial hypertension (high blood pressure in the lungs, abbreviated PAH) and a weak heart muscle (heart failure).
- Trial name
- CALIPSO (NCT04610788)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Johns Hopkins University
Scleroderma, Systemic
The SPIN - Scleroderma Support Group Leader EDucation Program Trial (SPIN-SSLED)
Many people living with scleroderma, a rare autoimmune connective tissue disease, attend support groups to help them cope with the disease.
- Trial name
- SPIN-SSLED (NCT03965780)
- Testing
- SPIN-SSLED Program
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute