Clinical trials: Diastolic Heart Failure
Heart Failure With Preserved Ejection Fraction
The Effects of Ranolazine on Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction
The purpose of this study is to determine whether treatment with Ranolazine will improve exercise capacity in patients with Heart Failure with preserved left ventricular ejection fraction, or HFPEF.
- Trial name
- RAZE (NCT01505179)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Diego
Heart Failure, Diastolic
Respiratory Muscle Function in Heart Failure
This study is being done because investigators are trying to determine how respiratory muscle and lung function influence the exercise responses in heart failure and healthy participants.
- Trial name
- NCT03924479
- Testing
- PowerBreathe (Breathing muscle training)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diastolic Heart Failure
A Randomized Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Effects of Alagebrium on Exercise in Subjects With Diastolic Heart Failure
The purpose of the study is to gather information regarding the safety and effectiveness of an investigational drug called Alagebrium when used treating Heart Failure in relation to exercise tolerance after 6 months in the trial.
- Trial name
- BREAK-DHF-1 (NCT01913301)
- Testing
- Alagebrium
- Volunteers
- 134 people
- Sponsor
- Cardiovascular Clinical Sciences Inc
Congestive Heart Failure, Diastole
Aldosterone Antagonism in Diastolic Heart Failure
The primary purpose of this study is to determine whether eplerenone has a beneficial effect on improving exercise ability in patients with diastolic heart failure.
- Trial name
- NCT00108251
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- US Department of Veterans Affairs
Heart Failure, Heart Failure, Diastolic
Impact of Beta-blockers on Physical Function in HFpEF
The purpose of this study is to understand the impact of beta-blockers on physical function in older adults with heart failure. We will achieve this objective by conducting N-of-1 trials.
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- NCT04767061
- Testing
- Beta blockers
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Weill Medical College of Cornell University
Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction
Sex Related Differences in Cardiac Function
The aim of the study is to investigate sex-specific differences in LV and RV function (systolic and diastolic) with regarding the development and progression of heart failure with preserved ejection fraction based on a…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT05796050
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Heart Failure
Development of Specific Diagnostic Tools for Cardiac Insufficiency With Preserved Ejection Fraction
The MeDIAGSTOLE project aims to develop diagnostic tools for heart failure with preserved ejection fraction (IC / FEp), a pathology that is difficult to diagnose and to manage clinically in the absence of targeted treatment .
- Trial name
- MeDIAGSTOLE (NCT04699890)
- Testing
- Blood sampling, questionnaires and specific exams
- Where
- France
- Volunteers
- 91 people
- Sponsor
- University Hospital, Montpellier
Heart Failure
Effect of Exercise-based Rehabilitation on Circulatory Functions in Patients With Diastolic Heart Failure
The purpose of this study is to investigate how exercise-base rehabilitation influences circulatory functions in patients with diastolic heart failure (DHF).
- Trial name
- NCT01053091
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Heart Failure and Preserved Ejection Fraction, Obesity (Disorder)
OBESE-HFpEF: Towards Preventing Obesity Related HFpEF
Obesity, severe overweight, is a growing problem worldwide and increases the risk of heart failure, especially a type called heart failure with preserved ejection fraction (HFpEF). In HFpEF, the heart becomes stiffer.
- Conditions
- Heart Failure and Preserved Ejection Fraction, Obesity (Disorder), Heart Failure
- Trial name
- OBESE-HFpEF (NCT07539766)
- Where
- Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Heart Failure, Diastolic
HbA1c as an Early Serologic Marker for the Hemodynamic Progression of Stage A Heart Failure
In a retrospective community based cohort study from Pueblo County Colorado which has a higher population proportion of metabolic syndrome and diabetes mellitus, we hope to clarify and quantify an association of the AGE HBa1c…
- Trial name
- NCT04450576
- Testing
- Glycosylated hemoglobin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Parkview Medical Center
Hypertension, Pulmonary, Ventricular Dysfunction, Left
A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Diastolic Dysfunction
The aim of this study is to assess whether single oral doses of Riociguat safely improve the cardiovascular function in patients with pulmonary hypertension associated with left ventricular diastolic dysfunction
- Trial name
- DILATE (NCT01172756)
- Testing
- Riociguat (BAY63-2521)
- Where
- 7 sites in Austria, Czechia and 1 more
- Volunteers
- 39 people
- Sponsor
- Bayer
Heart Failure, Diastolic
Stratified Treatment to Ameliorate Diastolic Left Ventricular Stiffness in Heart Failure With Preserved Ejection Fraction
A 35-week, single-center, prospective, double-blind, controlled, randomized, 2x2 crossover, interventional Phase II study, investigating the effect of treatment with dapagliflozin 10mg od on Left Ventricular distensibility in…
- Trial name
- STADIA-HFpEF (NCT04475042)
- Testing
- Dapagliflozin
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Mariëlle Scheffer
Heart Failure
Pilot Feasibility Study of the Safety and Efficacy of Anakinra in Heart Failure With Preserved Ejection Fraction
This will be a randomized, double-blind, crossover pilot study to measure the safety and feasibility of Interleukin-1 (IL-1) blockade with Anakinra in patients with stable heart failure with preserved ejection fraction.
- Trial name
- NCT01542502
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Heart Failure, Cardiovascular Disease
Use of Nesiritide in the Management of Acute Diastolic Heart Failure
Primary objective is to assess the effect of nesiritide in decreasing left ventricular (LV) filling pressure, defined as pulmonary artery capillary wedge pressure (PCWP) in a group of patients admitted with acute diastolic heart…
- Conditions
- Heart Failure, Cardiovascular Disease, Acute Heart Failure, Diastolic Heart Failure
- Trial name
- NCT00083772
- Testing
- Nesiritide
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
Heart Failure, Diastolic
Radiofrequency-based Speckle Tracking Echocardiography to Evaluate Diastolic Function
The purpose of this study is to evaluate a novel ultrasound system's ability to assess the relaxing properties of the heart compared to current techniques.
- Trial name
- RF-SPEED (NCT01182805)
- Testing
- Echocardiography system Ultra DCI Model 5000, Echocardiography machine GE Vivid E9, Diastolic function assessment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Heart Failure, Cardiovascular Disease
Rhode Island Diastolic Dysfunction - Heart Failure
To study the hypothesis that treating patients with underlying diastolic dysfunction with oral Kuvan® (BH4, also known as tetrahydrobiopterin) in addition to current best practices will improve metabolic and echocardiographic…
- Trial name
- RIDD-HF (NCT02353312)
- Testing
- Kuvan
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Providence VA Medical Center
Diastolic Heart Failure, Hypertensive Heart Disease
Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)
The purpose of this study is to examine how dietary changes affect the heart and blood vessels in patients with hypertension (high blod pressure) who have a condition called 'heart failure with preserved ejection fraction"…
- Trial name
- NCT01942395
- Testing
- DASH/sodium-restricted diet (DASH/SRD), Control Diet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Heart Failure, Heart Failure, Diastolic
MyoMobile Study: App-based Activity Coaching in Patients with Heart Failure and Preserved Ejection Fraction
The MyoMobile study is a single-center, randomized, controlled three-armed cohort study with prospective data collection to investigate the effect of a personalized mobile health intervention compared to usual care on the…
- Trial name
- MyoMobile (NCT04940312)
- Testing
- App-based physical activity coaching, No Intervention: Observational Cohort, Intervention Group 1
- Where
- Germany
- Volunteers
- 193 people
- Sponsor
- Johannes Gutenberg University Mainz
Diabetes Mellitus, Type 2, Heart Failure Preserved Ejection Fraction
Neuromuscular Fatigue and Exercise Capacity in Patients With Type 2 Diabetes Mellitus and HFpEF
An important feature of patients with HFpEF is impaired exercise tolerance, resulting in worsening and reduced quality of life. Studies in the literature on patients with HFpEF suggest that the limited transport of oxygen to the…
- Trial name
- NCT06057623
- Testing
- Evaluation of central and peripheral neuromuscular fatigue
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Atrial Fibrillation, Heart Failure, Diastolic
The Effect of Different Low-Level Tragus Stimulation Parameters On Autonomic Nervous System Function
Low level transcutaneous vagus nerve stimulation (LLTS) involves delivery of electrical impulses transcutaneously at the auricular branch of vagus nerve and it has been shown to have anti-inflammatory and anti-arrhythmic effects.
- Trial name
- LLT-SPANS (NCT04682704)
- Testing
- Parasym
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma