Clinical trials: Diastolic Dysfunction
Valvular Heart Disease Patients, Aortic Stenosis
Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE)
Heart valve disease and weakened heart muscle (left ventricular systolic dysfunction) are common in older adults and often go undetected until serious complications such as heart failure develop.
- Conditions
- Valvular Heart Disease Patients, Aortic Stenosis, Mitral Regurgitation, Left Ventricular Diastolic Dysfunction
- Trial name
- IMPROVE (NCT07756398)
- Testing
- Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.)
- Where
- 2 sites in United States
- Volunteers
- 1,088 people
- Sponsor
- University of Texas Southwestern Medical Center
Left Ventricular Diastolic Dysfunction
Characterization of Patients With Post-ischemic Left Ventricular Dysfunction
This is an observational, prospective, multicenter study (12 hospitals belonging to the Italian Cardiology Network) in patients with STEMI ST elevation myocardial infarction (STEMI) treated successfully with primary percutaneous…
- Trial name
- NCT04699565
- Testing
- Cardiac magnetic resonance
- Where
- 10 sites in Italy
- Volunteers
- 303 people
- Sponsor
- IRCCS San Raffaele
Diastolic Heart Failure, Diastolic Dysfunction
CORolla® TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD)
The study objective is to demonstrate safety and feasibility of the CORolla® TAA during 12 months of follow up, and to evaluate the performance of the therapy in relieving symptoms and restore diastolic function in patients with…
- Trial name
- NCT02499601
- Testing
- CORolla™ TAA device
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- CorAssist Cadiovascular Ltd.
Heart Failure With Preserved Ejection Fraction, Diastolic Heart Failure
Classification of Heart Failure With Preserved Ejection Fraction
The purpose of this study is to create a classification system for the heterogenous disorder of heart failure with preserved ejection fraction (HFpEF).
- Trial name
- NCT01030991
- Where
- United States
- Volunteers
- 514 people
- Sponsor
- Northwestern University
Heart Failure
Prospective Aerobic Reconditioning Intervention Study
The purpose of this study is : To determine if aerobic exercise conditioning can improve symptoms, cardiovascular function and quality of life in elderly patients with congestive heart failure.
- Trial name
- PARIS (NCT01113840)
- Testing
- Exercise, Control
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Wake Forest University
Hereditary Hemochromatosis
Cardiac Function in Patients With Hereditary Hemochromatosis
This study will examine the effect of iron buildup in the hearts of patients with hereditary hemochromatosis (HH), a genetic disease that causes the body to accumulate excess amounts of iron.
- Trial name
- NCT00068159
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Cardiac Structure and Function in Patients with Cystic Fibrosis
In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis, Pulmonary, Cystic Fibrosis of Pancreas
- Trial name
- NCT06084468
- Where
- 2 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Herlev and Gentofte Hospital
HIV Infections
Mechanisms of Cardiac Dysfunction in HIV and the Effect of Statins: A Cardiac MRI Study
In this study, investigators plan to test whether statins can preserve and/or improve diastolic function among asymptomatic persons with HIV who are on anti-retroviral therapy.
- Trial name
- NCT03238755
- Testing
- Cardiac MRI/MRS
- Where
- 4 sites in United States, South Africa
- Volunteers
- 129 people
- Sponsor
- Massachusetts General Hospital
Obesity, Heart Disease
Weight Loss in Pre-Hypertensive Patients With Diastolic Dysfunction
The focus of this study is to observe the impact of weight loss in overweight individuals who have pre-hypertension (have a blood pressure reading of 121-139/81-89 mm Hg).
- Conditions
- Obesity, Heart Disease, Weight Loss, Diastolic Dysfunction
- Trial name
- NCT00911209
- Testing
- Dietitian counselling
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ragavendra Baliga
Sepsis, Diastolic Dysfunction
Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients
Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality.
- Conditions
- Sepsis, Diastolic Dysfunction, Lung Edema, Fluid Overload
- Trial name
- NCT03768752
- Where
- Germany
- Volunteers
- 83 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heart Failure, Left Ventricular Dysfunction
Effects of Viagra on Heart Function in Patients With Heart Failure
Sildenafil (Viagra) is known to reduce pulmonary hypertension. Heart failure patients also have pulmonary hypertension and several recent reports have shown that sildenafil leads to an improvement in their exercise capacity.
- Trial name
- NCT00781508
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- MetroHealth Medical Center
Chronic Stable Heart Failure
Efficacy and Safety of TRC041266 in Patients With Heart Failure, LVEF ≥40%, Diastolic Dysfunction and Type 2 Diabetes Mellitus
This study will be conducted as a randomized, multi-centre, double-blind, parallel-group, placebo-controlled study in patients receiving SoC therapy.
- Trial name
- NCT04507347
- Testing
- TRC041266
- Sponsor
- Torrent Pharmaceuticals Limited
Diastolic Dysfunction
Diastolic Function Assessment With Cardiac Magnetic Resonance Imaging
Cardiac magnetic resonance (CMR) imaging is excellent at assessing the contractility of the heart muscle. However, relatively little is known about CMR's ability to assess the relaxation (diastolic function) of the heart between…
- Trial name
- DIAMER (NCT05438030)
- Testing
- Cardiac MRI scan, Echocardiogram scan
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Imperial College London
Diastolic Dysfunction and Cardiac Stiffness
Cardiac Elastography Measurement : an Intraoperative Cardiac Surgery Study
Since 20 years, the techniques of direct measurement of cardiac stiffness in the diagnosis of myocardial diseases do not exist. We propose a human study evaluating the direct measurement of cardiac ultrasound stiffness by…
- Trial name
- REA-FO (NCT02051920)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Psoriasis, Cardiovascular Diseases
Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis
In a prospective cohort study (n = 1.000), the investigators aim to investigate the correlation between cardiac biomarkers and advanced echocardiography and determine whether these are prognostic markers of heart disease in…
- Conditions
- Psoriasis, Cardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Pathology
- Trial name
- PSOCADIA (NCT04950218)
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev and Gentofte Hospital
Heart Failure With Preserved Ejection Fraction, Cardiovascular Morbidity
Arterial Stiffening as a Predictor for Diastolic Cardiac Dysfunction and HFpEF
Patients at risk for developing heart failure with preserved ejection fraction (HFpEF) will undergo a structured clinical assessment, transthoracic echocardiography and pulse-wave analysis to investigate the association of…
- Trial name
- ARTSPREDICTION (NCT06208007)
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Hyperuricemia, Metabolic Syndrome
Hyperuricemia and Left Ventricular Diastolic Function
Metabolic syndrome and hyperuricemia were both associated with inflammation, leading to diversities of cardiovascular disease such as left ventricular diastolic dysfunction, but the relationship among these entities remained…
- Conditions
- Hyperuricemia, Metabolic Syndrome, Left Ventricular Diastolic Dysfunction
- Trial name
- NCT03495999
- Testing
- hyperuricemia
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- National Defense Medical Center, Taiwan
Diabetes Mellitus, Type 2, Obesity, Abdominal
Ghrelin and Diastolic Heart Function
In type 2 diabetes mellitus (T2DM) and obese patients the adipose tissue could over-express cytokines, sirtuin-1 (SIRT1), and microRNAs (miRs) implied in the regulation of left ventricle (LV) diastolic function (LV-DF).
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Abdominal, Diastolic Dysfunction
- Trial name
- NCT05988346
- Testing
- abdominal plastic intervention
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Systolic Dysfunction
Association of PICP Serum Marker in Patients With LVSD
The purpose of this study is to determine if the carboxy-terminal of procollagen type I (PICP) can be a useful marker of different degrees of myocardial fibrosis.
- Trial name
- NCT00232388
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Heart Failure, Cardiovascular Diseases
Heart Failure and Related Risk-factors After Preeclampsia
This study is a cross-sectional case-control study where classical as well as more innovative risk factors for CVD will be explored.
- Conditions
- Heart Failure, Cardiovascular Diseases, Pre-Eclampsia
- Trial name
- QoH (NCT02347540)
- Where
- Netherlands
- Volunteers
- 2,580 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center