Clinical trials: Diagnoses Disease
Sarcoma, Soft Tissue Tumors
Magnetic Resonance Imaging or Ultrasound in Soft Tissue Tumors (MUSTT)
Adult soft tissue sarcomas (STS) are rare tumours with an estimated incidence averaging 5/100 000/year in Europe. The prognosis of soft tissue sarcomas is dominated by local recurrence and distant metastasis.
- Conditions
- Sarcoma, Soft Tissue Tumors, Ultrasound, Magnetic Resonance Imaging
- Trial name
- MUSTT (NCT02834585)
- Testing
- Ultrasound
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Genova
Multiple Sclerosis
Open Label Randomized Multicenter to Assess Efficacy & Tolerability of Ofatumumab 20mg vs. First Line DMT in RMS
This study will compare ofatumumab vs. European approved platform first line self-administered disease modifying therapy (DMT) in newly diagnosed MS patients
- Trial name
- STHENOS (NCT04788615)
- Testing
- Ofatumumab, First line DMT
- Where
- 41 sites in France, Germany and 2 more
- Volunteers
- 185 people
- Sponsor
- Novartis Pharmaceuticals
Crohn Disease, Complex Perianal Fistula
A Study to Check How Often People Treated With Darvadstrocel for Crohn's Disease Are Diagnosed With Cancer
The main aim is to learn about the risk of cancer after treatment with darvadstrocel compared to other standards of care in people with Crohn's Disease (CD).
- Trial name
- NCT04971525
- Where
- 4 sites in France, Germany and 2 more
- Sponsor
- Takeda
Esophageal Cancer, Anastomotic Leakage
Detection of Anastomotic Leakage After Esophageal Surgery
Anastomotic leakage is a major complication in esophageal surgery. Although contrast swallow is the current standard to exclude anastomotic leakage postoperatively, endoscopy may be superior.
- Trial name
- NCT00642525
- Testing
- Contrast swallow radiography, endoscopy
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Heidelberg University
Elective Posterior Lumbar Spinal Fusion for Spinal Stenosis, Spondylolisthesis
Assessing the Diagnostic Accuracy of Corrected Flow Time (FTc) and Pleth Variability Index (PVI) as Predictors of Fluid Responsiveness in Patients in the Prone Position Using the Jackson Table
Appropriate fluid management is an important part of anesthesia in patients undergoing surgery, and several dynamic indices have been suggested to have high predictability for fluid responsiveness in patients receiving mechanical…
- Conditions
- Elective Posterior Lumbar Spinal Fusion for Spinal Stenosis, Spondylolisthesis, Spinal Fractures, Scoliosis or Tumors
- Trial name
- NCT02826889
- Testing
- Philips Intelivue MP70 monitor, Pleth Variability Index (PVI)
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Yonsei University
Thrombocytopenia
The International ITP Registry
Primary immune thrombocytopenia (ITP) is an uncommon disease characterised by a low platelet count, which may cause the patient to have a higher risk or increased duration of bleeding.
- Trial name
- NCT01970189
- Where
- 44 sites in Australia, Colombia and 8 more
- Volunteers
- 500 people
- Sponsor
- South Eastern Sydney Local Health District
Chronic Kidney Disease
Urinary Biomarker-Based Diagnostic and Monitoring System for Chronic Kidney Disease and Real-World Effectiveness of SGLT2 Inhibitors
This prospective observational study aims to assess the association between real-world use of sodium-glucose co-transporter 2 inhibitors (SGLT2i; e.g., empagliflozin, dapagliflozin) and renal function decline in adults with…
- Trial name
- NCT07348484
- Testing
- Empagliflozin
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Venetoclax Plus Zanubrutinib for the Treatment of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
This phase II trial tests the effect of venetoclax in combination with standard of care (SOC) zanubrutinib in treating patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
- Trial name
- NCT07734038
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Kerry Rogers
Myocardial Infarction
Interest of TTC for the Early Diagnosis of Acute Myocardial Infarction at Autopsy
Ischemic heart disease is the leading cause of death worldwide and the leading cause of sudden cardiac death. However, its post-mortem diagnosis is particularly difficult because the gross examination of the heart is usually…
- Trial name
- INFARCTOPSY (NCT04924426)
- Testing
- TTC immersion
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Osteoarthritis, Fibromyalgia
Assessing Central Aspects of Pain
BACKGROUND: Chronic pain continues for more than 12 weeks despite medication or treatment. Chronic pain is the main symptom of muscle and joint problems, rarely explained by damage to the muscle and joints alone.
- Conditions
- Osteoarthritis, Fibromyalgia, Chronic Low Back Pain, Inflammatory Arthritis
- Trial name
- AsCent (NCT06518278)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Nottingham
Acute Febrile Illness, Use of Antimicrobial Agents
Comparison of Rates of Antimicrobial Use in Febrile Patients With or Without the Use of C-reactive Protein Blood Test
In Health Posts of rural areas operated by the Government of Nepal, there are limitations of tests to differentiate between bacterial and viral infections.
- Conditions
- Acute Febrile Illness, Use of Antimicrobial Agents, C-reactive Protein Level
- Trial name
- CREATIB (NCT05292508)
- Testing
- C-reactive Protein Rapid Diagnostic Test
- Where
- Nepal
- Volunteers
- 924 people
- Sponsor
- Patan Academy of Health Sciences
Organoids, Rectal Cancer
Organoids in Predicting Chemoradiation Sensitivity on Rectal Cancer
Patients with locally advanced rectal cancer will receive biopsy before the standard treatment of neoadjuvant chemoradiation. The investigators are going to establish organoids model from the pre-treatment biopsies and expose…
- Conditions
- Organoids, Rectal Cancer, Chemoradiation
- Trial name
- NCT03577808
- Testing
- Biopsy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhen Zhang
Acute Respiratory Failure, Critical Illness
Lactate/Albumin Ratio and Mortality in Respiratory Failure
This retrospective observational study aims to evaluate the association between the lactate-to-albumin ratio (LAR) measured at ICU admission and 28-day mortality in adult patients admitted to the intensive care unit with acute…
- Conditions
- Acute Respiratory Failure, Critical Illness, Mortality, Mortality Prediction
- Trial name
- NCT07909226
- Testing
- Assessment of Admission Serum Lactate-to-Albumin Ratio (LAR)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,250 people
- Sponsor
- Kocaeli City Hospital
Ovarian Neoplasm Epithelial, Ovarian Cancer
Oregovomab Plus Chemotherapy in Neo-adjuvant Setting in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer
A clinical study to compare the efficacy and safety of five administrations of oregovomab versus placebo, infused in schedule dependent sequence with specific cycles of a standard six-cycle chemotherapy regimen (paclitaxel and…
- Conditions
- Ovarian Neoplasm Epithelial, Ovarian Cancer, Fallopian Tube Neoplasms, Peritoneal Carcinoma
- Trial name
- NCT05605535
- Testing
- Oregovomab, Paclitaxel, Carboplatin
- Where
- 14 sites in India
- Volunteers
- 88 people
- Sponsor
- CanariaBio Inc.
Endometrium Cancer
Development of a Molecular Diagnostic Tool for Endometrial Cancer.
WomEC is an in vitro diagnostic test for Endometrial Cancer (EC) based on the detection of the expression level of a combination of 5 proteins in the soluble fraction of a pipelle biopsy specimen.
- Trial name
- NCT06192017
- Testing
- WomEC
- Where
- 26 sites in Spain
- Volunteers
- 1,950 people
- Sponsor
- MiMARK Diagnostics, S.L.
Anterior Cruciate Ligament Stability
Reliability and Diagnostic Accuracy of an Alternate Lachman's Test Performed in a Prone Position
This study is investigating the reliability and diagnostic accuracy of a Lachman's test conducted in a prone position to detect the presence of a torn anterior cruciate ligament.
- Trial name
- NCT01301014
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Lymphoblastic Leukemia, Adult
RWE of Pediatric-like Protocol for AYA Patients With Ph-negative ALL
This is a multicenter, observational real world clinical trial with prospective follow up that will evaluate the treatment outcome of adolescent and young patients with ph-negative acute lymphoblastic leukemia with first-line…
- Trial name
- NCT05127148
- Testing
- Evaluation of survival and toxicities in AYA Ph-negative ALL patients treating in first line depending on risk category.
- Where
- 2 sites in Argentina
- Volunteers
- 100 people
- Sponsor
- Grupo Argentino de Tratamiento de la Leucemia Aguda
Lung Cancer
Assessment of Diagnostic Yield Using a Robotic Navigational Bronchoscopy System With CBCT
The aim of this research study is to evaluate the effectiveness of the ION endoluminal system at reaching and obtaining biopsies from lung nodules when used in combination with 3-dimensional imaging such as CT scans.
- Trial name
- NCT06084208
- Testing
- Biopsy with the Robotic- Ion Endoluminal System with Adjunct Real-time Imaging
- Where
- Netherlands
- Volunteers
- 132 people
- Sponsor
- Intuitive Surgical
Infectious Pneumonia, Coma
Key to Improve DiagNosis in Aspiration Pneumonia
To evaluate the diagnostic performance of amylase assay performed from bronchial alveolar fluid to differentiate aseptic chemical inhalation pneumonitis from an infectious inhalation pneumonitis in comatose patients with…
- Trial name
- KIDNAP (NCT03182387)
- Where
- France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Bordeaux
Colorectal Cancer
Inflammation Biomarkers in the Diagnosis of Postoperative Infectious Complications in Colorectal Cancer Surgery
This is a longitudinal, single-center, prospective study to determine the efficiency of WBC Count, CRP, PCT, Neutrophil CD64 and Monocyte Human Leukocyte Antigen- DR in the diagnosis of postoperative infectious complications in…
- Trial name
- NCT03559335
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
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