Clinical trials: Diabetic Neuropathy
Chronic Limb-Threatening Ischemia, Diabetic Foot
Observational Study Regarding the Necessity of Inclusion of Foot Arch State Together With the Angiosome Theory Within the Wound, Ischemia and Foot Infection Classification (WIfI) to Enhance the Predictability of Wound Healing and Decision Making
This study aims to assess the complete healing or healing progress of foot ulcer within 1 year Where the patients will be classified according to foot arch state together with the angiosome theory and the WIFI clinical stage to…
- Conditions
- Chronic Limb-Threatening Ischemia, Diabetic Foot, Vascular Diseases
- Trial name
- NCT06542523
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Diabetic Foot Ulcers
A Study to Investigate the Safety and Clinical Effect of Nexagon® as a Topical Treatment for Subjects With a Diabetic Foot Ulcer (DUNE)
This study is for Type I or Type II diabetic subjects with with a diabetic foot ulcer. The study is being done to determine if Nexagon® plus standard of care is more effective than placebo plus standard of care.
- Trial name
- DUNE (NCT01490879)
- Testing
- Nexagon® Low Dose, Nexagon® Medium Dose, Nexagon® High Dose
- Where
- 25 sites in United States, Russia and 1 more
- Volunteers
- 168 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Diabetic Foot Ulcer
The ASCEND Study: A Study to Investigate the Safety and Clinical Effect of Nexagon to Treat Slow Healing Diabetic Foot Ulcers
Diabetic foot ulcers are sores on the feet that occur in 15% of diabetic patients some time during their lifetime. Once an ulcer develops, the risk of lower-extremity amputation is increased 8-fold in people with diabetes.
- Trial name
- NCT00820703
- Testing
- Nexagon®, Nexagon® vehicle
- Where
- New Zealand
- Volunteers
- 24 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Diabetic Neuropathies
Evaluation of Topical Citrullus Colocynthis Fruit Oil Efficacy in Treatment of Painful Peripheral Diabetic Neuropathy
This study is designed to evaluate the topical Citrullus colocynthis fruit oil efficacy in treatment of painful peripheral diabetic neuropathy (PDN) in a randomized double blind placebo-controlled clinical trial design.
- Trial name
- NCT02155361
- Testing
- Topical Citrullus colocynthis fruit oil (1%), Topical vehicle oil
- Where
- 2 sites in Iran
- Volunteers
- 70 people
- Sponsor
- Shiraz University of Medical Sciences
Obliterans, Arteriosclerosis, Peripheral Arterial Disease
Combined Treatment for Non-Healing Wounds in Chronic Lower Extremity Arterial Disease: A Comparative Study
Endovascular interventions, such as balloon angioplasty and stenting, are commonly used for PAD due to their proven safety and effectiveness. However, traditional treatments for chronic non-healing wounds are often insufficient.
- Conditions
- Obliterans, Arteriosclerosis, Peripheral Arterial Disease, Diabetic Foot
- Trial name
- NCT06724276
- Testing
- balloon angioplasty and stenting of lower extremity vessels + fibroblasts, balloon angioplasty and stenting of lower extremity vessels
- Where
- Kazakhstan
- Volunteers
- 116 people
- Sponsor
- Tulip Medicine
Peripheral Neuropathy, Diabetic Neuropathies
Focal Vibrations and Neuropathic Pain in Diabetic Peripheral Neuropathy
Most of the literature found on whole body vibrations(WBV) instead of focal muscle vibrations (FMV) in diabetic peripheral neuropathy patients.
- Trial name
- NCT05322746
- Testing
- Focal muscle vibration
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Riphah International University
Foot Ulcer
A Personalized Self-care Support Program for Primary Care Patients With Diabetic Foot Ulcer
This clinical trial aims to learn if a personalized self-care program supporting self-care and Healing through Empowerment and Active Listening (HEALing), is acceptable to patients with diabetic foot ulcer (DFU) and wound care…
- Trial name
- NCT06540170
- Testing
- A personalised self-care support program
- Where
- Singapore
- Volunteers
- 29 people
- Sponsor
- National Healthcare Group Polyclinics
Diabetic Foot Disease, Diabetic Foot Infection
Intraosseous Versus Intravenous Vancomycin in Below-Knee Amputation for Ischemic Diabetic Foot
This randomized clinical trial compared two routes of vancomycin administration in patients undergoing below-knee amputation for ischemic diabetic foot infection.
- Conditions
- Diabetic Foot Disease, Diabetic Foot Infection, Diabetic Amputation Foot Wound
- Trial name
- NCT07338773
- Testing
- Intraosseous Vancomycin, Intravenous Vancomycin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Diabetic Foot Ulcer
Laser Therapy for At-Home Treatment of DIabetic Foot Ulcers
The global prevalence of diabetes is on the rise and with it increase in prevalence of diabetic foot ulcers (DFU). These recalcitrant wounds are difficult to manage and pose a heavy economic burden.
- Trial name
- LLL&DIAB-01 (NCT03687320)
- Testing
- B-Cure Pro
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Erika Carmel ltd
Diabetes, Diabetic Foot
TEWL Biomarker Study for Diabetic Foot Ulcer Recurrence
This is a multicenter study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict DFU wound recurrence.
- Conditions
- Diabetes, Diabetic Foot, Diabetic Foot Ulcer, Diabetic Wound
- Trial name
- TEWL (NCT04558775)
- Testing
- Observational
- Where
- 6 sites in United States
- Volunteers
- 418 people
- Sponsor
- University of Michigan
Diabetic Peripheral Neuropathic Pain (DPN)
Hyperbaric Oxygen Therapy Versus High Power Laser for Diabetic Neuropathy
The purpose of this study is to compare the clinical effects of Hyperbaric Oxygen Therapy (HBOT) versus High-Intensity Laser Therapy (HPLT) on sensorimotor functions and nerve conduction in patients suffering from painful…
- Trial name
- HBOT-HPLT-DPN (NCT07848867)
- Testing
- Conventional Physiotherapy Program, Hyperbaric Oxygen Therapy, High-Intensity Laser Therapy
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Diabetic Peripheral Neuropathy, Diabetic Neuropathy
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy
The aim of the current study is to measure the effect of melatonin as adjunct therapy on oxidative stress, inflammatory markers and clinical outcome in type 2 diabetic patients with diabetic peripheral neuropathy.
- Conditions
- Diabetic Peripheral Neuropathy, Diabetic Neuropathy, Diabetic Peripheral Neuropathy in Type 2 Diabetic Patients
- Trial name
- NCT07036796
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 2, Diabetic Foot
Non-invasive Imaging for In-vivo Quantification of Skin Composition and Structure
The goal of this clinical investigation is to explore a non-invasive technology for measuring the microcirculatory structure, composition and function in patients from a primary care population. The main aims are: 1.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Foot, Peripheral Arterial Disease, Skin Cancer
- Trial name
- Spectrum1 (NCT06976073)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Post Herpetic Neuralgia, Diabetic Peripheral Neuropathy
Titration Study of ABX-1431
This study is designed to identify a titration regimen of ABX-1431 in adults with neuropathic pain with satisfactory tolerability to central nervous system (CNS) adverse events (AEs).
- Conditions
- Post Herpetic Neuralgia, Diabetic Peripheral Neuropathy, Small Fiber Neuropathy, Post-Traumatic Neuralgia
- Trial name
- NCT03447756
- Testing
- ABX-1431
- Where
- Moldova
- Volunteers
- 39 people
- Sponsor
- Abide Therapeutics
Foot Ulcer, Diabetic
GrafixPRIME® for the Treatment of Chronic Diabetic Foot Ulcers
The objective of the study is to compare the efficacy of weekly GrafixPRIME® administration to an Active Comparator in patients with chronic DFUs in a randomized, single-blind study.
- Trial name
- NCT02675855
- Testing
- GrafixPRIME®, Dressing Application, Off-loading (walking boot)
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Osiris Therapeutics
Diabetes, Foot Ulcer
STEP UP to Avert Amputation in Diabetes
This study will evaluate a comprehensive tailored behavioral intervention aimed to improve foot self-care and self-monitoring (combined with dermal thermometry) to prevent recurrent ulcers in Veterans at highest risk of…
- Trial name
- STEP UP (NCT02356848)
- Testing
- Tailored Intervention (TI), Current Practice (CP)
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- VA Office of Research and Development
Diabetic Foot, Ulcer Foot
Bioactive Split Thickness Skin Allograft Versus Standard of Care in the Treatment of Diabetic Foot Ulcers
This study is a prospective, multi-center, randomized controlled trial designed to collect patient outcome data as well as assess performance and safety of a commercially available human split thickness skin allograft with SOC…
- Trial name
- NCT04040426
- Testing
- Human split thickness skin allograft, Additional Outer Dressing Applicaiton, Offloading
- Where
- 5 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Professional Education and Research Institute
Venous Leg Ulcer, Diabetic Foot Ulcer
The Omeza Protocol for Chronic Ulcers
This study will compare the Omeza® Products Bundle to standard of care (SOC) for in subjects with chronic venous leg ulcers and subjects with diabetic foot ulcers.
- Trial name
- NCT04198441
- Testing
- Wound dressing
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- Omeza, LLC
Diabetic Peripheral Neuropathy, Chinese Medicine
LiuWeiLuoBi Granule for the Treatment of Diabetic Peripheral Neuropathy
Based on network pharmacology, Liuweiluobi Granule was screened to treat diabetes peripheral neuropathy with deficiency of the spleen and kidney and stasis-heat syndrome.In the preliminary animal experiment, it suggested that…
- Conditions
- Diabetic Peripheral Neuropathy, Chinese Medicine, Nerve Conduction
- Trial name
- NCT04457531
- Testing
- LiuWeiLuoBi Granule, Standard medical treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China Academy of Chinese Medical Sciences
Peripheral Diabetic Neuropathy, Cardiovascular Autonomic Neuropathy
The Association Between Cognitive Function and Neuropathy in Individuals With Type 2 Diabetes
The goal of this observational study is to evaluate whether individuals with different types of diabetic neuropathy (peripheral and cardiovascular autonomic neuropathy) are at an increased risk of cognitive impairment and to…
- Conditions
- Peripheral Diabetic Neuropathy, Cardiovascular Autonomic Neuropathy, Cognitive Impairment, Diabetes Type 2
- Trial name
- ASCEND (NCT06857994)
- Where
- Denmark
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen