Clinical trials: Diabetic Ketoacidosis, open to volunteers
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Type 1 Diabetes, Celiac Disease
General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery
In partnership with Helmsley Charitable Trust, the Sanford PLEDGE Study is a large-scale, observational, feasibility study of general population screening for T1D and celiac autoantibodies.
- Trial name
- PLEDGE (NCT04477928)
- Testing
- Sera and whole blood sampling, Differential Gene Expression (DGE)
- Where
- 4 sites in United States
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Diabetic ketoacidosis (DKA) is a severe metabolic complication in children with newly diagnosed type 1 diabetes mellitus (T1DM) and may be associated with early injury of vital organs such as the kidneys and the heart.
- Trial name
- NCT07483879
- Testing
- Biomarker and Echocardiographic Assessment
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Type 1 Diabetes, Type 2 Diabetes
Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT-2 Inhibitors
The purpose of this research is to see how well a special education plan using continuous ketone monitoring (DGK) works to lower the risk of a condition called diabetic ketoacidosis (DKA) in people with type 1 diabetes (T1D)…
- Trial name
- KARMA (NCT07421518)
- Testing
- SGLT-2 inhibitor (Sotagliflozin), Insulin withdrawal test (IWT)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute