Clinical trials: Diabetes type2
Type2 Diabetes Mellitus, Chronic Kidney Disease
A Study of ONO-3310 in Healthy Adult Male Subjects and Chronic Kidney Disease Patients With Type 2 Diabetes Mellitus
To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of ONO-3310 in healthy Japanese adult male subjects and chronic kidney disease patients with type 2 diabetes…
- Trial name
- NCT07619157
- Testing
- ONO-3310
- Where
- Japan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Diabetes Mellitus, Type 2, Diabetes
Dietary Approaches to Stop Hypertension for Diabetes
The objective of the DASH4D trial is to determine the effects, alone and combined, of (a) the DASH4D diet (a DASH-style diet modified for people with diabetes) vs.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes, Diabetes type2, Type2 Diabetes
- Trial name
- DASH4D (NCT04286555)
- Testing
- DASH4D diet, comparison diet, higher sodium
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Johns Hopkins University
Type2 Diabetes Mellitus, Stable Coronary Artery Disease
Effects of SGLT2 Inhibition on Myocardial Insulin Sensitivity
A Phase III, single-centre, randomized, 2-arm, parallel-group, double blind, placebo-controlled study, consisting of a screening phase (Days -14 to -1), a 4-week double-blind, placebo-controlled treatment phase and a 4-week…
- Trial name
- DapaHeart (NCT03313752)
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Giaccari Andrea
Heart Diseases, Type2 Diabetes
Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing…
- Conditions
- Heart Diseases, Type2 Diabetes, Hypertension, Obesity
- Trial name
- PROSPECT (NCT03794531)
- Where
- Puerto Rico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Type2 Diabetes Mellitus, Atherosclerotic Cardiovascular Disease
Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Trial name
- NCT07203677
- Testing
- Initiation of tirzepatide, Initiation of sitagliptin
- Where
- United States
- Volunteers
- 49,065 people
- Sponsor
- Brigham and Women's Hospital
Atherosclerotic Vascular Disease, Type2 Diabetes
The Effects of Evolocumab in Patients With Diabetes and Atherosclerotic Vascular Disease
Experimental models have linked lipid lowering therapies with systemic inflammation; however, relatively little is known about this network in clinical populations and specifically how it changes with PCSK9 inhibition.
- Conditions
- Atherosclerotic Vascular Disease, Type2 Diabetes, Microvascular Dysfunction
- Trial name
- NCT03829046
- Testing
- Evolocumab
- Where
- 2 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- Robert Rosenson
Type2 Diabetes Mellitus
High Protein Effect on Body Composition and Sarcopenia Markers in Older Patients With Type 2 Diabetes Mellitus
This study will investigate the impact of dietary protein intake on progressive muscle loss and functionality (sarcopenia) in older adults with type 2 diabetes mellitus.
- Trial name
- NCT05457088
- Testing
- 1.5 protein, 0.8 protein
- Where
- Greece
- Volunteers
- 25 people
- Sponsor
- National and Kapodistrian University of Athens
Impaired Glucose Tolerance, Type2 Diabetes
Influence of Preprandial Metformin Administration on Carbohydrate Absorption
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.
- Trial name
- METTIME (NCT04018105)
- Testing
- Oral glucose tolerance test (OGTT) with or without metformin
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
PreDiabetes, Diabetes type2
Intermittent Fasting to Improve Insulin Secretion
Type 2 diabetes (T2D) mellitus is a challenge for health care systems as the numbers increases constantly. In 2014, 422 million people had been living with diabetes worldwide.
- Conditions
- PreDiabetes, Diabetes type2, Intermittent Fasting, Insulin Secretion
- Trial name
- IFIS (NCT04607096)
- Testing
- Intermittent fasting, Control diet
- Where
- 8 sites in Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Tuebingen
Physical Inactivity, Type2 Diabetes Mellitus
Behavioral Change Communication for Physical Activity Among Females With Type2 Diabetes Mellitus
The marked discrepancy between predicted and actual prevalence of Type2 diabetes Mellitus (DM) with the actual cases rising earlier than expected, underscore the continuing relevance of tailored awareness and management…
- Trial name
- RCT (NCT00690326)
- Testing
- Behavioral change communication model(BCC) to promote physical activity, pamphlet-The printed pamphlet,'Physical activity:To control blood sugar/ Diabetes Mellitus'
- Where
- India
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Thiruvananthapuram Medical College
Bariatric Surgery Candidate, Type2 Diabetes
Dapagliflozin Effect on Glucose Variability in Patients Post Bariatric Surgery
This study evaluates the effect of SGLT-2 inhibitors (dapagliflozin) on the blood glucose excursions by a continuous glucose monitoring system, the incidence of hypoglycemia and hyperglycemia and change in glycated hemoglobin…
- Trial name
- NCT07515391
- Testing
- Dapagliflozin 10 MG
- Where
- Kuwait
- Volunteers
- 30 people
- Sponsor
- Dasman Diabetes Institute
Type2 Diabetes, Heart Failure With Preserved Ejection Fraction
SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
The study team will examine the effects of SGLT2i (and SGLT2i-induced increases in plasma ketone concentrations) on skeletal muscle and cardiac ketone uptake, skeletal muscle bioenergetics, cardiopulmonary exercise capacity, and…
- Trial name
- NCT05057806
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type2 Diabetes
Cardio-metabolic and Inflammatory Impact of Starch Digestibility in Type 2 Diabetic Patients
This is a monocentric, randomized, single-blind and controlled study with a parallel design (2 arms). The research hypothesis is that the diet high in Slow Digestible Starch (SDS) content (H-SDS) will lower the daylong glycemic…
- Trial name
- NCT03847701
- Testing
- Balanced diet high in Slowly Digestible Starch, Balanced diet low in Slowly Digestible Starch
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Mondelēz International, Inc.
Diabetes type2, Bariatric Surgery Candidate
Diabetes Reversal and the Subgingival Microbiota
This study seeks to examine the impact of bariatric surgery on oral bacteria in diabetic compared to non-diabetic patients. The purpose of this research study is to examine how diabetes changes the bacteria in the mouth.
- Trial name
- NCT05501093
- Testing
- sample collection
- Where
- 2 sites in United States
- Volunteers
- 102 people
- Sponsor
- University of Pennsylvania
Obesity &Amp;Amp; Overweight, Gastric Emptying Time
Observational Study on GER in Patients With Simple Obesity
Dear Patients, The investigators invite participants to take part in an observational study on gastric emptying rate in individuals with simple obesity.
- Conditions
- Obesity &Amp;Amp; Overweight, Gastric Emptying Time, Type2 Diabetes Mellitus
- Trial name
- NCT07188571
- Testing
- Gastric emptying scintigraphy
- Where
- China
- Volunteers
- 163 people
- Sponsor
- Jing Ma
Type2 Diabetes, Life Style
Intensive Diet and Physical Activity on Diabetes
It is a multicenter, open-label, parallel-group, randomized controlled clinical trial, which is designed to enroll newly diagnosed type 2 diabetes patients with overweight or obesity.
- Trial name
- IDEATE (NCT03839667)
- Testing
- intensive diet intervention, Enhanced physical activity intervention, Standard education
- Where
- China
- Volunteers
- 326 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type2 Diabetes, Peripheral Neuropathy
A Causative Role for Amylin in Diabetic Peripheral Neuropathy
Three pieces of information lead to the basis for this study: 1. Individuals with Type-2 diabetes commonly develop peripheral neuropathy. 2.
- Trial name
- NCT03481283
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Zabeen Mahuwala, MD
Type2 Diabetes Mellitus
"Effect of Omega-3 Supplementation as Add on Therapy on Glycemic Control and Lipid Profile in Type2 Diabetes Mellitus."
The goal of this clinical trial is to learn if Omega-3 works to control glycemic status, improve lipid profile in Type2 Diabetic patients. It will also learn about the safety of drug Omega-3.
- Trial name
- NCT07352618
- Testing
- Omega-3 Fatty Acids
- Where
- Bangladesh
- Volunteers
- 66 people
- Sponsor
- Bangladesh Medical University
Genetics Disease, Type2 Diabetes
Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a…
- Conditions
- Genetics Disease, Type2 Diabetes, Heart Failure
- Trial name
- NCT04323189
- Testing
- Sitagliptin 100mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Overweight and Obesity, Type2 Diabetes
The Mobile Lifestyle Intervention for Food and Exercise Study
The goal of the study is to examine long term sustained weight loss digital intervention in a diverse cohort of adults with overweight/obesity.
- Trial name
- mLIFE (NCT05176847)
- Testing
- Podcasts and tips of the day (within app), mLIFE app (self-regulation features), mLIFE app (social support features)
- Where
- United States
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- University of South Carolina