Clinical trials: Diabetes Mellitus, Type 1
Type 1 Diabetes
Screening For Social Determinants Of Health In Routine Diabetes Care
Social determinants of health (SDOH) exert a powerful influence on the everyday management of type 1 diabetes (T1D) and short and long term outcomes of T1D.
- Trial name
- SDOH (NCT07706803)
- Testing
- Social Determinants of Health (SDOH) Screening and Referral
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Los Angeles
Insulin-Dependent Diabetes
Feasibility of Simulation in Therapeutic Patient Education for Adult Diabetic Patients Using the Freestyle Libre® Device
The benefits of Therapeutic Patient Education (TPE) have long been proven, but its implementation remains insufficient. It is only accessible to a part of the population and is too often limited to the acquisition of knowledge.
- Trial name
- PRE-SIMPA (NCT03956927)
- Testing
- S-TPE, Questionnaires
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Type1 Diabetes Mellitus
Evaluation of the Dreamed Advisor Pro for Automated Insulin Pump Setting Adjustments in Children and Adolescents With Type 1 Diabetes- The Advice4U Pro Study
The DreaMed Advisor Pro is a software which automatically analyses treatment information, learns patient's needs and accordingly suggests adjustments in insulin dosing.
- Trial name
- Advice4U (NCT03003806)
- Testing
- DreaMed Advisor Pro, Medical guided recommendation
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 122 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus, Non-Insulin-Dependent
Evaluate the Role of Adding Amaryl to Non-Insulin Dependent Diabetes Mellitus Patients Unresponsive to Maximum Dose Metformin & Thiazolidinedione
The purpose of this study is to assess the efficacy and safety of Amaryl when added to Metformin and Thiazolidinedione (TZD) in non-insulin dependent diabetes mellitus (NIDDM) patients.
- Trial name
- NCT00044447
- Testing
- Glimepiride
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Sanofi
Type 1 Diabetes Mellitus With Hypoglycemia, type1diabetes
Intermediate and Long Acting Insulin Young Children Type 1 Diabetes.
Background: Achieving glycemic control without risking hypoglycemia imposes a major challenge in the management of toddlers and preschool children with Type 1 diabetes(T1D).
- Trial name
- NCT04664764
- Testing
- Degludec, Glargine, NPH insulin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Type 1 Diabetes, Type2diabetes
Liom Non-invasive Continuous Glucose Monitor "Clinical Demo" (niCGM)
This is a single-centre, multiple cohort, open study.
- Trial name
- NCT06272136
- Testing
- Clinical Demo 2.0
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Liom Health AG
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes
Current intensive insulin therapy in T1D involves prandial insulin boluses depending on the carbohydrate content of each ingested meal.
- Trial name
- NCT02490098
- Testing
- 6-day intervention with sensor-augmented pump therapy, 6-day intervention with single-hormone closed-loop strategy, 6-day intervention with dual-hormone closed-loop strategy
- Where
- Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 2 Diabetes, Osteoporosis
Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes
The DIACTIVE study is a randomized controlled trial with a 5- year follow-up designed to evaluate the impact of comprehensive screening and multicomponent interventions on fall prevention, bone health, nerve function and…
- Conditions
- Type 2 Diabetes, Osteoporosis, Diabetic Neuropathies, Fall Prevention
- Trial name
- DiaACTIVE (NCT06745544)
- Testing
- Rhythm- and Multitask-Based Activity (RYMA) and Activities of Daily Living (ADL)
- Where
- Denmark
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Obesity, Nutritional Deficiency
Comparison of Weight Loss and Nutritional Deficiency After One Anastomosis Gastric Bypass at 150, 170, and 200 cm From the Duodenojejunal Junction
This study is a randomized clinical trial comparing the effects of One Anastomosis Gastric Bypass performed at three different distances from the duodenojejunal junction-150 centimeters, 170 centimeters, and 200 centimeters-on…
- Conditions
- Obesity, Nutritional Deficiency, Type 2 Diabetes Mellitus (T2DM), Bariatric Surgery (Gastric Bypass)
- Trial name
- NCT06664099
- Testing
- One Anastomosis Gastric Bypass (150 cm from Duodenojejunal Junction), One Anastomosis Gastric Bypass (170 cm from Duodenojejunal Junction), One Anastomosis Gastric Bypass (200 cm from Duodenojejunal Junction)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Diabetes, Hypoglycemia
A Study to Improve Diabetes Management Among Adults Experiencing Severe Hypoglycemia
This pilot study will assess the feasibility, preliminary efficacy, and acceptability of the Diabetes-REM (Rescue, Engagement, and Management), a comprehensive patient-centered intervention delivered by community paramedics in…
- Conditions
- Diabetes, Hypoglycemia, Diabetes Type 1, Diabetes Type 2
- Trial name
- NCT04874532
- Testing
- Community Paramedic Program, Education Material
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes
Evaluation of The Postprandial Impact of Automated Priming Bolus for Full Closed Loop Insulin Delivery
The purpose of this study is to understand the impact of the automated priming boluses on the safety and feasibility of a new fully automated AP controller.
- Trial name
- Rocket-BPS (NCT05528770)
- Testing
- FCL+BPS, FCL
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Marc Breton
Newly Diagnosed With Type 1 Diabetes
Prevention of Diabetes Progression Trial (PDPT)
The primary purpose of this study is to determine the efficacy and safety of daclizumab in preventing the progression of diabetes in children who have just been diagnosed with type I diabetes.
- Trial name
- NCT00198146
- Testing
- Zenapax
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Type 1 Diabetes Mellitus
PK and PD Within-Subject Variability of a Single Dose of Afrezza Inhaled Technosphere Insulin in Patients With Diabetes Mellitus Type 1 (T1DM)
Primary Objective: To characterize the within-subject variability in systemic exposure pharmacokinetic (PK) to insulin of a replicate single dose of Afrezza inhaled Technosphere Insulin (TI) in T1DM patients in a euglycemic clamp…
- Trial name
- NCT02485327
- Testing
- Technosphere Insulin SAR439065 Afrezza®
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Mannkind Corporation
Type 1 Diabetes
Additional Insulin for Fat and Protein in Children With Diabetes Study
The aims of the study are to see if additional insulin doses for the fat and protein in a meal, given at different times, improve blood glucose levels and are safe and acceptable to children with Type 1 diabetes using multiple…
- Trial name
- NCT02680054
- Testing
- Insulin, Asp(B28)-
- Where
- 2 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- Oxford University Hospitals NHS Trust
Type 1 Diabetes
Liraglutide Effect on Beta-cell Function in C-peptide Positive Type 1 Diabetes
Recent studies show that many Type 1 diabetes patients have remaining endogenous insulin production, albeit at low levels. Finding means to increase this production would be of tremendous interest, since residual C-peptide…
- Trial name
- NCT02617654
- Testing
- Liraglutide
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Per-Ola Carlsson
Islets of Langerhans Transplantation, Diabetes Mellitus, Type 1
Islet Transplant Alone in OMENtum
The study is a phase 2, monocentric, open-label study. The investigators will recruit 12 patients with T1D to be randomly (1:1) assigned to receive islet either into the liver through the portal venous circulation (standard…
- Trial name
- ITA-OMEN (NCT02803905)
- Testing
- Biological: Islet transplantation
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Lorenzo Piemonti
Diabetes
Circulating Biomarkers in the Development of Type 1 Diabetes
More than 100 million U.S. adults are now living with diabetes or prediabetes. Investigators still do not fully understand how diabetes develops and how the disease worsens.
- Trial name
- NCT05505669
- Testing
- One-time blood (up to 100 ml) will be drawn and the amount of blood drawn is based on weight. Saliva and urine will be collected during the blood draw visit.
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Type 1 Diabetes Mellitus
CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM)
The primary objectives of this study are to compare the difference in glycosylated hemoglobin (HbA1c) from baseline to Month 6 using Hylenex recombinant preadministration in continuous subcutaneous insulin infusion (CSII) versus…
- Trial name
- NCT01848990
- Testing
- Commercial Hylenex® recombinant (hyaluronidase human injection), Precommercial Hylenex recombinant (hyaluronidase human injection), Insulin lispro
- Where
- 39 sites in United States
- Volunteers
- 456 people
- Sponsor
- Halozyme Therapeutics
Type 1 Diabetes, Type 2 Diabetes
The Effect of Different Food Products on Post Prandial Blood Glucose in Pregnant Woman With Diabetes
During pregnancy nutrition demands change and the pregnant woman needs to adjust her food intake and take into consideration the corrected daily recommendations for micro and macro nutrients.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes
- Trial name
- NCT02154997
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uri Elchalal
Diabetes Mellitus, Type 1
Positron Emission Tomography (PET) Imaging of Pancreatic Beta-Cell Mass in Healthy and Type 1 Diabetic Patients
Pancreatic Islet beta-cells are responsible for synthesizing and secreting appropriate amounts of insulin to regulate blood glucose levels. One factor in the development of diabetes is the loss of beta-cells.
- Trial name
- NCT00958997
- Testing
- 18F-FP-DTBZ (18F-AV-133), Arginine-hydrochloride
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yale University
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