Clinical trials: Dexmedetomidine, open to volunteers
Postoperative Pain, Total Hip Arthroplasty (THA)
Safety and Efficacy of Dexamethasone Versus Dexmedetomidine as Adjuvants in PENG Block in Hip Surgeries for Postoperative Pain Management
This study evaluates and compares the analgesic efficacy and safety of adding dexamethasone versus dexmedetomidine to bupivacaine in an ultrasound-guided pericapsular nerve group (PENG) block combined with a lateral femoral…
- Trial name
- NCT07847047
- Testing
- Bupivacaine 0.25%, Dexamethasone, Dexmedetomidine
- Volunteers
- 90 people
- Sponsor
- Assiut University
Obesity, Postoperative Pain
Dexmedetomidine Versus Ketamine as Adjuvants in Bariatric Surgery
This randomized controlled trial aims to compare the analgesic efficacy of dexmedetomidine infusion versus low-dose ketamine infusion as adjuvants in bariatric surgery.
- Conditions
- Obesity, Postoperative Pain, Bariatric Surgery
- Trial name
- NCT06738043
- Testing
- Dexmedetomidine infusion, Ketamine infusion
- Volunteers
- 90 people
- Sponsor
- Tanta University
Analgesia, Patient-Controlled, Dexmedetomidine
Two-channel IV-PCA With Dexmedetomidine
Dexmedetomidine was administered in the 'selector' channel and fentanyl in the 'basic \& bolus' channel of dual channel intravenous patient-controlled analgesia (IV-PCA) and the amount of opioid consumption was compared.
- Trial name
- NCT05672225
- Testing
- Dexmedetomidine, Control
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Korea University Guro Hospital
Emergence From Anesthesia
Comparison Between Total Intravenous Anesthesia With Magnesium Sulphate Versus Total Intravenous Anesthesia With Dexmedetomidine in Patients Undergoing Lumbar Spine Surgeries
Although total intravenous anesthesia (TIVA) provides advantages such as accelerated recuperation and diminished postoperative nausea, it also has constraints, such as the potential for hemodynamic instability and inadequate…
- Trial name
- NCT07443163
- Testing
- Dexmedetomidine (Precedex®), magnesium sulfate
- Volunteers
- 40 people
- Sponsor
- Cairo University
Bariatric Surgery, Lidocaine
Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Sleeve Gastrectomy
Although laparoscopic (LAP) bariatric surgery is minimally invasive. Following any laparoscopic procedure, patients typically experience the peak of postoperative pain within the first 24 hours.
- Conditions
- Bariatric Surgery, Lidocaine, Dexmedetomidine
- Trial name
- NCT07327905
- Testing
- intravenous lidocaine, intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Chronic Post-Surgical Pain
Effect of Perioperative Dexmedetomidine on Chronic Post-Surgical Pain
The goal of this clinical trial is to learn if intranasal dexmedetomidine works to improve sleep quality to treat chronic post-surgical pain (CPSP) in patients undergoing thoracic surgery.
- Trial name
- NCT06849466
- Testing
- Dexmedetomidine, Saline solution
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Peking Union Medical College Hospital
Hip Fractures
Effects of Esketamine Combined With Dexmedetomidine on Postoperative Sleep Quality
1. Eligible patients are randomly divided into experimental and control groups； 2. The experimental group is given esketamine combined with dexmedetomidine，while the control group is given normal saline； 3.
- Trial name
- NCT07002723
- Testing
- Esketamine combined with dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking University Shenzhen Hospital
Laryngoscopic Stress Response, Dexmedetomidine
Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial
After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication.
- Conditions
- Laryngoscopic Stress Response, Dexmedetomidine, Lignocaine
- Trial name
- NCT07611890
- Testing
- IV dexmedetomidine, IV Lignocaine
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Rawalpindi Institute of Cardiology
Post-operative Pain, Upper Limb Surgery
Lidocaine vs. Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA) in Upper Limb Surgery
This study compares lidocaine alone vs. lidocaine with dexmedetomidine in Intravenous regional anesthesia (IVRA) for upper limb surgery in terms of pain scores and duration of analgesia
- Conditions
- Post-operative Pain, Upper Limb Surgery, Regional Anesthesia
- Trial name
- NCT07034300
- Testing
- Lidocaine (drug), Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Fatima Memorial Hospital
Dexmedetomidine, Delirium
Effect of Dexmedetomidine on Postoperative Delirium After Awake Craniotomies
Postoperative delirium (POD) is a common complication, and the incidence of POD ranges from 10% to 60%. Previous studies suggested that frontal approach and tumor located at the temporal lobe were independent risk factors for POD…
- Conditions
- Dexmedetomidine, Delirium, Awake Craniotomy
- Trial name
- NCT05195034
- Testing
- Dexmedetomidine, 0.9% saline
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Tiantan Hospital
Pain Management
Dexmedetomidine in Postoperative Analgesia
There is a high incidence reaching up to 45%; of severe intraoperative and postoperative pain associated with arthroscopic shoulder surgery, which is often significant enough to interfere with initial recovery and…
- Trial name
- Any (NCT05705128)
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- New Valley University
Postoperative Pain
Intravenous Dexamethasone as an Adjuvant to Dexmedetomidine After Superior Trunk Block for Arthroscopic Shoulder Surgery
This study aims to evaluate whether adding intravenous dexamethasone to standard intravenous dexmedetomidine improves pain control after shoulder arthroscopy performed under a superior trunk block.
- Trial name
- STB-DEXA (NCT07525934)
- Testing
- Dexamethasone, Dexmedetomidine, Sodium Chloride 0.9%
- Volunteers
- 70 people
- Sponsor
- Recep Karakaşoğlu
Postoperative Pain Management
Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine
The investigators are evaluating postoperative outcomes in patients undergoing hip replacement surgery performed with either spinal or general anesthesia, who also receive a suprainguinal fascia iliaca block using either…
- Trial name
- NCT07316166
- Testing
- Dexmedetomidine, Ropivacaine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rhode Island Hospital
PreTerm Neonate, Sedation for Invasive Mechanical Ventilation
Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants
Very preterm neonates (born before 32 weeks' gestation) often require invasive mechanical ventilation (IMV) to manage respiratory insufficiency.
- Conditions
- PreTerm Neonate, Sedation for Invasive Mechanical Ventilation, Very Preterm Neonates With Sedation for Invasive Mechanical Ventilation
- Trial name
- DEXPRE (NCT06878703)
- Testing
- Midazolam, Dexmedetomidine
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Heart Disease, Coronary Artery Disease
Intranasal Dexmedetomidine and Perioperative Myocardial Injury in Patients Having Percutaneous Coronary Interventions
The goal of this clinical trial is to determine the effect of pre-operative dexmedetomidine on periprocedural myocardial injury in patients having percutaneous coronary intervention (PCI).
- Trial name
- PRIME (NCT07847580)
- Testing
- Intranasal dexmedetomidine, Normal Saline
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Caudal Block for Postoperative Analgesia
Effect of Adding Different Concentrations of Dexmedetomidine to Bupivacaine in Caudal Block for Pediatrics
Pain is one of the medical problems frequently misdiagnosed, undertreated, and poorly under-stood, particularly in children.Poor pain management during childhood may have long-term deleterious impacts, including damaging…
- Trial name
- NCT06668220
- Testing
- Dexmedetomidine, Bupivacain
- Volunteers
- 50 people
- Sponsor
- Assiut University
Delirium in the Intensive Care Unit
Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive Care
The goal of this clinical trial is to learn if dexmedetomidine can reduce delirium in critically ill children, needing mechanical ventilation for more than 12 hours.
- Trial name
- PEDIADEX (NCT07542990)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 7 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Tours
Adenotonsillectomy
Dexmedetomidine as Adjuvant for Suprazygomatic Maxillary Nerve Block in Children's Adenotonsillectomy
The goal of this clinic trial is to evaluate the impact of dexmedetomidine as an adjunct pain pain medication on opioid-free recovery in children undergoing adenotonsillectomy with Suprazygomatic maxillary nerve block (SZMB).
- Trial name
- SZMB (NCT07013526)
- Testing
- Ropivacaine
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hypospadias
Comparison of Caudal Block and Sacral Erector Spinae Plane Block With Dexmedetomidine in Pediatric Penile Hypospadias Repair
Hypospadias is one of the most common congenital anomalies in childhood, requiring surgical reconstruction (1). It is a penile malformation with a more proximal or ventral location beyond the usual localization of the urethra.
- Trial name
- NCT07197203
- Testing
- Sacral ESP Block, Caudal epidural block
- Volunteers
- 66 people
- Sponsor
- Assiut University
Pain Management, Noncardiac Surgery
Preemptive Analgesia Of Dexmedetomidine Reduces Per-operation Pain
Background:Preemptive analgesia is the initiation of analgesic regimen before the onset of nociceptive stimulation, preventing the amplification of pain due to peripheral and central sensitization and thereby reducing subsequent…
- Trial name
- NCT06671327
- Testing
- Preemptive Dexmedetomidine injection, Sodium Chloride 0.9% Inj
- Where
- China
- Volunteers
- 208 people
- Sponsor
- China International Neuroscience Institution