Clinical trials: Dexmedetomidine, open to volunteers
Older Adults, Cognitive Impairment
Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment
Patients with cognitive decline are frequently comorbid with sleep disorders which may in turn aggravate cognitive decline. Sedative dose dexmedetomidine improved sleep quality but incresed bradycardia and hypotension; low dose…
- Conditions
- Older Adults, Cognitive Impairment, Sleep Disorders, Dexmedetomidine
- Trial name
- NCT07610343
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Laryngoscopic Stress Response, Dexmedetomidine
Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial
After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication.
- Conditions
- Laryngoscopic Stress Response, Dexmedetomidine, Lignocaine
- Trial name
- NCT07611890
- Testing
- IV dexmedetomidine, IV Lignocaine
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Rawalpindi Institute of Cardiology
Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids
Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery
This study will examine whether addition of dexmedetomidine or clonidine (two alpha-2 adrenergic agonists) will improve the comfort of patients during spinal anesthesia for cesarean delivery.
- Conditions
- Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids, Spinal Anesthesia for Cesarean Section, Dexmedetomidine
- Trial name
- NCT07567495
- Testing
- Clonidine, Dexmedetomidine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Sedation, Cataract
Dexmedetomidine and Propofol for Sedation in Cataract Surgery.
The goal of this prospective, randomized, single-blinded is to learn if there is an ideal sedation protocol in cataract surgery in adults.
- Conditions
- Sedation, Cataract, Hemodynamic, Hemodynamic Changes
- Trial name
- NCT07556133
- Testing
- Dexmedetomidine (DEX), Propofol (PRO), Fentanyl (FEN)
- Where
- Lebanon
- Volunteers
- 1,000 people
- Sponsor
- Saint-Joseph University
Major Abdominal Surgery, Postoperative Delirium (POD)
MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)
This study aims to determine whether, compared with placebo, the nighttime self-administration of a nasal dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in high-risk patients.
- Conditions
- Major Abdominal Surgery, Postoperative Delirium (POD), Sleep Disturbances, Intranasal Dexmedetomidine
- Trial name
- MIDDIES (NCT07538284)
- Testing
- Dexmedetomidine
- Volunteers
- 400 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Spinal Surgery, Pain Intensity
Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP).
- Conditions
- Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine
- Trial name
- NCT07525999
- Testing
- Combined dexmedetomidine-esketamine administration
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Peking University First Hospital
Spinal Surgery, Pain Intensity
Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP).
- Conditions
- Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine
- Trial name
- NCT07523321
- Testing
- Combined dexmedetomidine-esketamine administration
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Peking University First Hospital
General Anesthesia, Surgery
Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery
For patients after surgery, quality of recovery has significant impacts on the prognosis, quality of life, and rational allocation of medical resources.
- Conditions
- General Anesthesia, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07308756
- Testing
- Dexmedetomidine, Esketamine, Dexmedetomidine-esketamine
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Peking University First Hospital
Intrathecal Dexmedetomidine, Bupivacaine
Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery
This study aims to compare the duration of analgesia (as the primary outcome) and adverse effects (as the secondary outcome) after intrathecal administration of dexmedetomidine with hyperbaric bupivacaine to patients undergoing…
- Conditions
- Intrathecal Dexmedetomidine, Bupivacaine, Knee Orthopedic Surgery
- Trial name
- NCT07522736
- Testing
- Dexmedetomidine 4 μg, Dexmedetomidine 8 μg, Dexmedetomidine 12 μg
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Adenotonsillectomy, Children
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Postoperative pain after adenoid and tonsil surgery is significant, with approximately 75% of pediatric patients experiencing severe postoperative pain.
- Conditions
- Adenotonsillectomy, Children, Intranasal Administration, Dexmedetomidine
- Trial name
- NCT07479602
- Testing
- Intranasal dexmedetomidine-esketamine
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Peking University First Hospital
CABG, Dexmedetomidine
Role of Opioid Free Anaesthesia in Elderly Patients Undergoing Elective Coronary Artery Bypass Graft Surgeries With Cardiopulmonary Bypass in Enhanced Recovery After Surgeries
The introduction of synthetic opioids in 1960 to general anesthesia together with sedative hypnotics and muscle relaxants allowed the appearance of the concept of multimodal balanced anesthesia.
- Conditions
- CABG, Dexmedetomidine, Ketamine, Opioid Free Anesthesia
- Trial name
- NCT07360327
- Testing
- Opioid free anesthesia, Opioid based Anesthesia
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Virtual Reality, Dexmedetomidine
Virtual Reality Versus Intravenous Dexmedetomidine on Maternal Anxiety, Stress, Hemodynamics, and Neonatal Outcomes During Cesarean Section
This study aims to compare the efficacy of intravenous dexmedetomidine infusion versus virtual reality (VR) in reducing maternal anxiety, stress, and hemodynamic instability during cesarean section and their effects on neonatal…
- Conditions
- Virtual Reality, Dexmedetomidine, Maternal Anxiety, Stress
- Trial name
- NCT07343843
- Testing
- Dexmedetomidine, Virtual reality
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Benha University
Oral Melatonin, Nebulized Dexmedetomidine
Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy
This study aims to compare the efficacy of using oral Melatonin versus nebulized Dexmedetomidine in limitation of emergence agitation in children undergoing adenotonsillectomy.
- Conditions
- Oral Melatonin, Nebulized Dexmedetomidine, Emergence Agitation, Children
- Trial name
- NCT07345715
- Testing
- Normal saline, Oral melatonin syrup, Nebulized dexmedetomidine
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Tanta University
Effects of Dexmedetomidine & Magnesium Sulphate on Patients Undergoing DHS
Comparison Between Intrathecal Magnesium Sulphate & Dexmedetomidine in DHS
To compare the efficacy and safety of intrathecal dexmedetomidine and magnesium sulphate as adjuvants to 0.5% hyperbaric bupivacaine in patients undergoing elective DHS fixation, focusing on onset and duration of sensory and…
- Trial name
- NCT07326397
- Testing
- Dexmedetomidine, Magnesium Sulphate
- Volunteers
- 92 people
- Sponsor
- Assiut University
Bariatric Surgery, Lidocaine
Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Sleeve Gastrectomy
Although laparoscopic (LAP) bariatric surgery is minimally invasive. Following any laparoscopic procedure, patients typically experience the peak of postoperative pain within the first 24 hours.
- Conditions
- Bariatric Surgery, Lidocaine, Dexmedetomidine
- Trial name
- NCT07327905
- Testing
- intravenous lidocaine, intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Dexmedetomidine, Sedation
Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in Low-Monitoring Settings
The goal of this clinical trial is to assess the viability of dexmedetomidine hydrochloride nasal spray under minimal or no supervision and to further investigate novel clinical applications for this medication.
- Conditions
- Dexmedetomidine, Sedation, Safety, Preanesthetic Medication
- Trial name
- NCT07298525
- Testing
- Dexmedetomidine hydrochloride nasal spray
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Intrathecal, Dexmedetomidine
Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity
The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.
- Conditions
- Intrathecal, Dexmedetomidine, Fentanyl, Bupivacaine
- Trial name
- NCT07276867
- Testing
- Fentanyl + Dexmedetomidine, Fentanyl
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- National Cancer Institute, Egypt
Preoperative Anxiety, Preoperative Sedation
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period.
- Conditions
- Preoperative Anxiety, Preoperative Sedation, Children, Dexmedetomidine
- Trial name
- NCT06853431
- Testing
- dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Delirium, Cognitive Dysfunction
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated.
- Conditions
- Delirium, Cognitive Dysfunction, Cognition Disorder, Neurocognitive Disorders
- Trial name
- CODEX (NCT04289142)
- Testing
- Dexmedetomidine Hydrochloride Group
- Where
- 8 sites in Canada
- Volunteers
- 2,400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Fibromyalgia, Pregabalin
The Efficacy and Safety of Pregabalin Combined With Dexmedetomidine in Patients With Fibromyalgia
Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread pain, fatigue, and emotional disorders. Its onset is related to factors such as central sensitization and imbalance of neurotransmitters.
- Conditions
- Fibromyalgia, Pregabalin, Dexmedetomidine
- Trial name
- NCT07230197
- Testing
- Pregabalin, Pregabalin with dexmedetomidine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital