Clinical trials: Dexmedetomidine
Hysteromyoma
Effect of Dexmedetomidine on Stress Study of Pituitrin in Laparoscopic Hysteromyoma Surgery
This study is about the effect of dexmedetomidine to the stress of pituitrin in laparoscopic hysteromyoma surgery. It is well known that pituitrin has been widespread used in the laparoscopic hysteromyoma surgery.
- Trial name
- NCT03524950
- Testing
- Dexmedetomidine
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
PONV, Opioid Sparing Anaesthesia
Opioid Sparing Anaesthesia for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery
In spite of multimodal analgesic strategies, which consist of opioids, dexamethasone, non-steroidal anti-inflammatory drugs, and local anesthetics applied into the surgical wound, postoperative pain and postoperative nausea and…
- Trial name
- NCT04706897
- Testing
- Dexmedetomidine, ketamine and lidocaine, Normal saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Fiberoptic Bronchoscopy
Dexmedetomidine Nasal Spray and Pediatric Bronchoscopy
To observe the sedative effect of using dexmedetomidine nasal spray combined with remimazolam for pediatric bronchoscopy diagnosis and treatment, provide a safer and more comfortable anesthesia plan for pediatric bronchoscopy…
- Trial name
- NCT06755996
- Testing
- Dexmedetomidine injection, Remimazolam
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tongji Hospital
Cesarean Section
Dexmedetomidine Versus Magnesium Sulphate for Caesarean Delivery
Regional anesthesia has become more popular in cesarean deliveries because most of the parturients prefer being awake during the birth process. In addition, regional anesthesia may be a safer method than general.
- Trial name
- NCT03067896
- Testing
- Bupivacaine, Dexmedetomidine, Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sedation
Safety, Efficacy and Pharmacokinetic Study of Dexmedetomidine in Pediatrics Ages ≥28 Weeks to ≤44 Weeks Gestational Age
The purpose of this study is to investigate the safety, efficacy and pharmacokinetics (PK) of dexmedetomidine (DEX) at 3 different dose levels in infants, ages ≥28 weeks to ≤44 weeks gestational age, administered as a loading…
- Trial name
- NCT01159262
- Testing
- Midazolam, Fentanyl/Morphine, Dexmedetomidine
- Where
- 18 sites in United States, Guatemala
- Volunteers
- 36 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Hemodynamic Instability
Role of Nebulized Dexmedetomidine in Blunting the Effects of Direct Laryngoscopy and Endotracheal Tube on Heart Rate and Blood Pressure.
The goal of this interventional study is to check the effectiveness of nebulized Dexmedetomidine in preventing the rise in blood pressure and heart rate in patients undergoing General Anesthesia.
- Trial name
- NCT06103721
- Testing
- Dexmedetomidine Injection [Precedex], Normal Saline
- Where
- Pakistan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Post Operative Arrythmia
Dexmedetomidine and Magnesium Sulfate in Preventing Junctional Ectopic Tachycardia After Pediatric Cardiac Surgery
to study the prophylactic effect of magnesium sulfate , dexmedetomidine or their combination in reduction the incidence of JETS postoperative
- Trial name
- NCT05554848
- Testing
- Dexmedetomidine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Kasr El Aini Hospital
Pediatric, Sedation
Nebulized Dexmedetomidine as a Premedication for Gastrointestinal Endoscopy in Pediatric Patients
This study aims to demonstrate that the application of nebulized dexmedetomidine to patients during pediatric upper gastrointestinal endoscopic procedures will significantly reduce the gag reflex and enhance both patient and…
- Trial name
- NCT06218797
- Testing
- a routine sedation protocol, Nebulized with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ondokuz Mayıs University
Ankle Disease, Ankle Injuries and Disorders
Dexmedetomidine Vs Dexamethasone in Popliteal Nerve Block
Effect of Perineural Dexmedetomidine vs. Dexamethasone on the duration of popliteal nerve block for Anesthesia After Pediatric ankle/foot surgery.
- Conditions
- Ankle Disease, Ankle Injuries and Disorders, Foot Injury, Foot Diseases
- Trial name
- NCT06304324
- Testing
- 0.9% Sodium chloride, 0.1mg/kg Dexamethasone, 0.05ug/kg Dexmedetomidine
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Analgesia
Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine in Bilevel Erector Spinae Plane Block in Breast Surgeries
High percent of patients experience chronic pain following breast cancer surgeries thus proper perioperative pain control is crucial to lessen the incidence of such pain.
- Trial name
- NCT05591417
- Testing
- Bilevel Erector spinae plane block, Bilateral Erector spinae plane block with dexamethasone, Bilateral Erector spinae plane block with dexmedetomidine
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- National Cancer Institute, Egypt
Analgesia Disorder
Transverse Abdominal Block for Analgesia in Casarean Section
In this study, the investigators will compare the analgesic effect of bupivacaine and bupivacaine-dexmetomedine after elective cesarean delivery by performing an bilateral TAP block, on the patients for whom the operation will be…
- Trial name
- NCT02122510
- Testing
- Bupivacine group, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Agitated; State, Acute Reaction to Stress
Dexmedetomidine Combined With Hydromorphone in Tonsillectomy and Adenoidectomy
Tonsillectomy and adenoidectomy is one of the most common pediatric surgeries, and agitation and severe postoperative pain have been considered a very common complications.
- Trial name
- NCT03760809
- Testing
- Dexmedetomidine 0.5μg／kg, Dexmedetomidine 1μg／kg
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Airway Stress Response
Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients
This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy.
- Trial name
- NCT07034898
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Post-operative Pain
Dexmedetomidine Added to Bupivacaine for ESP Block in Children Undergoing Lower Abdominal Surgeries
This study aims to evaluate the effect of adding dexmedetomidine to bupivacaine in erector spinae plane (ESP) blocks on the duration of postoperative analgesia in pediatric patients undergoing lower abdominal surgery.
- Trial name
- NCT07023991
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Perioperative Blood Glucose and Insulin
Dexmedetomidine Influence on the Level of Perioperative Blood Glucose and Insulin of Elderly Diabetes Patients
Dexmedetomidine is a kind of high selectivity alpha 2 agonists adrenaline, can inhibit the activity of sympathetic nerve, alleviate pain,and improve cardiovascular stability in the operation period.
- Trial name
- NCT02154074
- Testing
- general anesthesia induction, Isoflurane, Dexmedetomidine
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Breast Cancer
The Effect of Dexmedetomidine of the Immune System
The goal of this research study is to learn about how dexmedetomidine (a standard of care sedative) affects your immune system (your defenses against cancer) by measuring your white blood cell levels before and after surgery.
- Trial name
- NCT01692210
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Depth of Anesthesia Monitoring, BIS-EEG
The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline Anesthesia
This prospective, single-center, randomized interventional study aims to investigate the effects of commonly used adjunct anesthetic drugs on the Bispectral Index (BIS) and electroencephalographic (EEG) activity during total…
- Trial name
- NCT07699523
- Testing
- Midazolam, Dexmedetomidine, Esketamine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Catheter Related Complication
Comparison of Tramadol and Dexmedetomidine in the Prevention of Urinary Catheter Discomfort in Urinary Surgery
The investigators aimed to compare the effects of tramadol and dexmedetomidine, which are commonly used in anesthesia, on preventing catheter-related bladder discomfort.
- Trial name
- NCT04314050
- Testing
- Tramadol, Dexmedetomidine, control
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Ankara Diskapi Training and Research Hospital
Ambulatory Orchipexy
Effect of Dexmedetomidine on the Characteristics of High Volume/Low Concentration Ropivacaine in a Caudal Block in Pediatrics
The investigators perform this study to evaluate the effects of caudal Dexmedetomidine (DEX) added to high volume/low-concentration of ropivacaine in children undergoing orchiopexy.
- Trial name
- NCT02163980
- Testing
- Caudal ropivacaine + normal saline, Caudal ropivacaine + dexmedetomidine
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Lidocaine, Dexmedetomidine
Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery
This study aims to compare lidocaine and dexmedetomidine infusion and their combination on perioperative pain in patients undergoing video-assisted thoracoscopic surgery.
- Conditions
- Lidocaine, Dexmedetomidine, Infusion, Perioperative Pain
- Trial name
- NCT06837519
- Testing
- Lidocaine, Dexmedetomidine, Lidocaine and Dexmedetomidine
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University