Clinical trials: Developmental Disability
Autism Spectrum Disorders
Open Label Extension Study of STX209 (Arbaclofen) in Autism Spectrum Disorders
This is an open-label extension protocol that will provide necessary data on the safety, tolerability, pharmacokinetics and efficacy of STX209 among subjects with ASD.
- Trial name
- NCT01706523
- Testing
- STX209 (arbaclofen)
- Where
- 25 sites in United States
- Volunteers
- 165 people
- Sponsor
- Seaside Therapeutics, Inc.
Schizophrenia, Bipolar Disorder
A Study to Evaluate the Safety and the Effects of Risperidone Compared With Other Atypical Antipsychotic Drugs on the Growth and Sexual Maturation in Children
The purpose of this study is to evaluate the effects of risperidone compared with other atypical antipsychotic drugs on the physical maturity, growth and development of children, and the risk of prolactin-related adverse events…
- Conditions
- Schizophrenia, Bipolar Disorder, Autistic Disorder, Conduct and Other Disruptive Behavior Disorders
- Trial name
- NCT01050582
- Testing
- Risperidone, Other atypical antipsychotic drugs
- Where
- 28 sites in United States, Belgium and 4 more
- Volunteers
- 244 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Autistic Disorder
Functional Behavioural Skill Training for Young Children With Severe Autism
LAY SUMMARY: IBI is costly and there are currently long waitlists of children who are in need of treatment. The investigators have clinical and ethical obligations to determine more appropriate alternatives to IBI for children…
- Trial name
- NCT00518804
- Testing
- Functional Behavioural Skills Group and Parent Training
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Hamilton Health Sciences Corporation
Intellectual Disability, Developmental Disability
Research Engagement With People With Intellectual and Developmental Disabilities
The objectives of this project are to to build sustainable regional communities of Intellectual or Developmental Disabilities (IDD) stakeholders to provide ongoing input to research priorities, methodological processes, and…
- Conditions
- Intellectual Disability, Developmental Disability, Chronic Conditions, Multiple
- Trial name
- PCORI (NCT04182347)
- Testing
- Health Research ToolKit Development
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Autism Spectrum Disorder
Feasibility and Safety of a Virtual-Reality Based Job Interview Training Tool in Teenagers With High-Functioning Autism
The current project involves the application of a VR job training software. We propose to use an interactive VR job interview practice system, Virtual Reality Job Interview Training (VR-JIT), in youths with ASD at the highschool…
- Trial name
- NCT04773548
- Testing
- VR-JIT
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Autism Spectrum Disorder, Parenting Stress
Feasibility and Acceptability of Laughter Yoga in Children With Autism Spectrum Disorder and Their Parents
This is a pilot randomised controlled trial to explore the acceptability and feasibility of laughter yoga about anxiety and depression reduction in children with ASD and parenting stress reduction for their parents.
- Conditions
- Autism Spectrum Disorder, Parenting Stress, Depression, Anxiety
- Trial name
- NCT06326255
- Testing
- laughter yoga
- Where
- Hong Kong
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- LAM Chung Yan Hemio
Mastication, Disability
Orofacial Functions and Masticatory Function in Children With Different Types of Deterioration in Oral Health
This project aims at studying the evolution of masticatory function (food bolus granulometry, masticatory behavior, muscle activity and masticatory performance) during oral rehabilitation, in children with different types of oral…
- Conditions
- Mastication, Disability, Oral Stage, Child Development
- Trial name
- KIDYCROC (NCT05821140)
- Testing
- dental treatment for global oral rehabilitation, oral health check up
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Clermont-Ferrand
Autism Spectrum Disorder, Autism
Pilot Trial of Pregnenolone in Autism
This is a research study to examine the tolerability and effectiveness of pregnenolone in individuals with autism. Pregnenolone is a naturally occurring steroid hormone in the brain that has been implicated in treating various…
- Trial name
- NCT02627508
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Old and Very Old People, Independent Living
Development of an ICF Core Set for Geriatric Patients in Primary Care
The sum of medical interventions can do more harm than good. Supporting patients' resources instead of combating disease might effectively help reducing "too much medicine".
- Conditions
- Old and Very Old People, Independent Living, Functioning
- Trial name
- ICF (NCT03384732)
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Autism Spectrum Disorder
Effectiveness of a Parent-mediated Intervention With PACT on Children With ASD
Autism Spectrum Disorder (ASD) is a neuro-developmental disorders. There are different types of interventions. Among these interventions Early Start Denver Model (ESDM) and Preschool Autism Communication Therapy (PACT) have…
- Trial name
- IFPAD (NCT04244721)
- Testing
- Preschool Autism Communication Therapy (PACT), Treatment As Usual (TAU)
- Where
- France
- Volunteers
- 212 people
- Sponsor
- Hôpital le Vinatier
CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay
Aprepitant for the Treatment of CLIFAHDD
There are no drug treatments for individuals with Congenital Contractures of the Limb and Face, Hypotonia, and Developmental Delay (CLIFAHDD), an ultra-rare and severe neurodevelopmental disease.
- Conditions
- CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay, NALCN Channelopathy, Ataxia - Other
- Trial name
- NCT07845825
- Testing
- Aprepitant Powder for Oral Suspension
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Autism Spectrum Disorder, Obesity
Semaglutide in Youth With Autism Spectrum Disorder
This study is a 6-month, two-arm, RCT which will evaluate the effectiveness and safety of semaglutide in adolescents aged 12-18 years with autism spectrum disorder (ASD) and obesity.
- Trial name
- GLP1 (NCT07770152)
- Testing
- Glucagon-like peptide-1 receptor agonist：Semaglutide, Lifestyle Management (LSM) Counseling
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autism Spectrum Disorder
A Pilot Study of Microbiome in Patients With Autism Spectrum Disorder and Their Unaffected Siblings
The primary aims are to identify important gut microbiota signatures for youth with ASD, to identify dysbiosis features for different levels of ASD features and clinical courses, to search the possibility to intervene the disease…
- Trial name
- NCT05038748
- Testing
- Psychiatric diagnosis, ASD diagnosis
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder
International Multicentric Observational Study to Characterize Subpopulations of Patients With Autism Spectrum Disorder
To determine sufficient number of biological and clinical markers to identify subgroups of potential best responders to a specific medication
- Trial name
- NCT05590715
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Stalicla SA
Autism Spectrum Disorders, ADHD
Novel Measure of Social Deficits in Children
Autism Spectrum Disorders (ASD) feature impairments in social interaction and communication. Drug and behavioral treatments for ASD are undergoing rapid development, yet our diagnostic tools are not suitable for efficacy…
- Trial name
- OATS (NCT02035176)
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Neurodevelopmental Abnormality
Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU)
A sub-study to evaluate longer-term developmental outcomes in non-vigorous term and near-term newborns who receive umbilical cord milking in comparison to those who undergo early cord clamping at delivery.
- Trial name
- MINVIFU (NCT03621943)
- Testing
- Umbilical Cord Milking, Early Cord Clamping
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 1,207 people
- Sponsor
- Sharp HealthCare
Autism, Asperger's Syndrome
Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety
Autism spectrum disorders affect as many as 1 out of 88 children and are related to significant impairment in social, adaptive, and school functioning.
- Conditions
- Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder
- Trial name
- NCT01919970
- Testing
- Cognitive Behavioral Therapy, Treatment as usual
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Autism Spectrum Disorder
FMS-CrossFit Training Program (FCTP) to Improve School Readiness in Preschool Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is an increasing public health concern, with preschool children often exhibiting persistent deficits in school readiness.
- Trial name
- NCT07532395
- Testing
- FCTP program, treatment as usual (TAU) (Control Group)
- Where
- 2 sites in China
- Volunteers
- 184 people
- Sponsor
- Peking University
Microdeletion Syndromes, Trisomy 21
Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA
The purpose of this study is to collect blood from families with a child who has been diagnosed with a chromosomal disorder including microdeletions in order to further develop a non-invasive prenatal screening test based on…
- Conditions
- Microdeletion Syndromes, Trisomy 21, Trisomy 18, Trisomy 13
- Trial name
- Microdel Triad (NCT02109770)
- Where
- 2 sites in United States
- Volunteers
- 216 people
- Sponsor
- Natera, Inc.
Nature, Human, Microbial Colonization
Biodiversity Interventions for Assisted Living Centers
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities, which weakens the functionality of the urban ecosystems and the well-being of citizens.
- Conditions
- Nature, Human, Microbial Colonization, Well-Being, Psychological, Immune System and Related Disorders
- Trial name
- BIWE (NCT06390683)
- Testing
- Rewilding
- Where
- Finland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Natural Resources Institute Finland