Clinical trials: Development
Asthma
Role of the Isomerase Pin-1 in the Development and Treatment of Asthma
Pin1 is activated in asthmatic airways, increasing cytokine mRNA stability and eosinophil survival. This study is designed to test whether the Pin1 enzyme regulates TLR/IL-1R signal pathways in multiple cells in asthma.
- Trial name
- Pin1 (NCT01691612)
- Testing
- installation of D. pteronyssinus allergens
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brigham and Women's Hospital
Cervical Spine Injury
Development and Testing of a Pediatric Cervical Spine Injury Risk Assessment Tool
Cervical spine injuries (CSI) are serious, but rare events in children. Spinal precautions (rigid cervical collar and immobilization on a longboard) in the prehospital setting may be beneficial for children with CSI, but are…
- Trial name
- C-Spine (NCT05049330)
- Where
- 18 sites in United States
- Volunteers
- 22,444 people
- Sponsor
- Julie Leonard
Adolescent and Young Adult Cancer Patient
Adolescents and Young Adults (AYAs) With Advanced Cancer
This study aims to develop and test the feasibility and acceptability of a psychosocial symptom management intervention designed to meet the unique needs of Adolescents and Young Adults (AYAs) with advanced cancer.
- Trial name
- NCT05593016
- Testing
- Symptom Management for Improved Physical and Emotional Wellbeing (SMILE), Education Control Arm
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Basal Cell Nevus Syndrome, Gorlin's Syndrome
Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas
The purpose of this study is to evaluate and compare the safety and efficacy of intermittent vismodegib and of Photodynamic Therapy (PDT).
- Trial name
- Vismodegib (NCT01556009)
- Testing
- Vismodegib, Aminolevulinic acid %20 topical solution
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Polycystic Ovary Syndrome (PCOS)
Androgen Excess as a Cause for Adipogenic Dysfunction in PCOS Women
The purpose of this research study is to collect specimen samples and study medical information from women with Polycystic Ovary Syndrome (PCOS) and women without PCOS.
- Trial name
- NCT01889199
- Testing
- Flutamide
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Seizure in Participants With Tuberous Sclerosis Complex, Seizure in Participants With Dravet Syndrome
Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures
This study will be conducted to evaluate the safety, pharmacokinetics (PK), and efficacy of adjunctive GWP42003-P in participants < 2 years of age with tuberous sclerosis complex (TSC), Lennox-Gastaut syndrome (LGS), or Dravet…
- Conditions
- Seizure in Participants With Tuberous Sclerosis Complex, Seizure in Participants With Dravet Syndrome, Seizure in Participants With Lennox-Gastaut Syndrome
- Trial name
- NCT04485104
- Testing
- GWP42003-P
- Where
- 11 sites in United States, Italy and 1 more
- Volunteers
- 3 people
- Sponsor
- Jazz Pharmaceuticals
Stroke
Development and Pilot Evaluation of a Web-supported Programme of Constraint Induced Therapy Following Stroke (LifeCIT)
When a person has had a stroke they often lose their confidence, motivation and the ability to move one arm and hand. Recent research has shown that intensive exercise assists recovery of movement, but people are often…
- Trial name
- NCT01350453
- Testing
- LifeCIT, Standard Care
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Southampton
Dental Plaque
Development of Clinical Method to Triclosan Retention in Plaque Following Brushing
The objective is to develop a method to determine active ingredient uptake in oral care products.
- Trial name
- NCT00762853
- Testing
- Fluoride, Fluoride and triclosan
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Autism
Oxcarbazepine Versus Placebo in Childhood Autism
The proposed study is designed to assess the effectiveness of treatment with Oxcarbazepine vs. placebo in childhood/adolescent autism.
- Trial name
- NCT00467753
- Testing
- Oxcarbazepine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Intellectual Disability, Autism
Enhancing Genomic Laboratory Reports to Enhance Communication and Empower Patients
Current lab reports are designed to communicate results from the laboratory to the provider; they are not designed to be accessible to patients.
- Conditions
- Intellectual Disability, Autism, Multiple Congenital Anomalies
- Trial name
- NCT02504502
- Testing
- enhanced genomic report
- Volunteers
- 52 people
- Sponsor
- Geisinger Clinic
Infant Development, Gut Microbiome
INF108F in Infants With Food Protein Induced Proctocolitis
Single-center, randomized, double-blind, placebo-controlled trail evaluating INF108F in breastfed infants with FPIAP
- Conditions
- Infant Development, Gut Microbiome, Food Protein Induced Allergic Proctocolitis
- Trial name
- RESTORE (NCT05793112)
- Testing
- INF108F probiotic
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Accidental Falls, Risk Assessment
AI-Powered Fall Risk Prediction in Nursing Care
The goal of this study is to develop a nursing clinical decision support system for fall risk prediction using machine learning and computer vision techniques.
- Conditions
- Accidental Falls, Risk Assessment, Nursing Assessment, Machine Learning
- Trial name
- NCT07000981
- Where
- Turkey (Türkiye)
- Volunteers
- 177 people
- Sponsor
- Inonu University
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development
Maternal Adversity, Vulnerability and Neurodevelopment
Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project is a prospective community-based, pregnancy and birth cohort of Canadian mother-child dyads.
- Conditions
- Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development, Infant Behavior
- Trial name
- MAVAN (NCT03434457)
- Where
- Canada
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Growth and Development
Investigation of Iron Uptake From Micronutrient Fortified Powder Versus From Tailored Control in Milk
The present study supplements iron as part of multiple micro-nutrient supplementation to demonstrate that intake of a micronutrient fortified powder in milk helps increase the uptake of key micronutrients like iron due to unique…
- Trial name
- NCT02254460
- Testing
- Test, Control
- Where
- India
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Colorectal Neoplasms, Melanoma
A Rollover Study for Patients Who Received Tremelimumab in Other Protocols, to Allow the Patients Access to Tremelimumab Until This Agent Becomes Commercially Available or Development is Discontinued.
This study is intended to provide access to tremelimumab for patients who have previously received tremelimumab in a clinical trial.
- Conditions
- Colorectal Neoplasms, Melanoma, Prostatic Neoplasms, Renal Cell Carcinoma
- Trial name
- NCT00378482
- Testing
- CP-675,206 (Tremelimumab)
- Where
- 6 sites in United States, United Kingdom
- Volunteers
- 37 people
- Sponsor
- AstraZeneca
Hip Impingement Syndrome, Prosthetic Complication
Retrospective Study on Radiological Factors Predictive of Psoas Impingement
The purpose of this study is to identify radiological factors on TC of the hip that could lead to prediction of development of symptomatic psoas impingement in patients with protruding acetabular cup after primary total hip…
- Trial name
- NCT05893823
- Testing
- Pelvis CT scan
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Istituto Ortopedico Rizzoli
Autistic Disorder
A Short Treatment Study of Aripiprazole in Pediatric Patients With Autistic Disorder
The objective of this study is to investigate the efficacy and safety of aripiprazole orally administered over a period of 8 weeks in pediatric patients with Autistic Disorder
- Trial name
- NCT01617447
- Testing
- Aripiprazole
- Where
- 5 sites in Japan
- Volunteers
- 92 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Healthy
Study of Stool Patterns to Collect a Panel of Stool Images for the Development of a Software
Collection of a panel of stool images from healthy infants/toddlers for the development of a software
- Trial name
- Poobao (NCT03402555)
- Testing
- Stool pattern
- Where
- 2 sites in United States, Singapore
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
SGA, Turner Syndrome
A Research Study Looking at How Safe Somapacitan is and How Well it Works in Children Who Need Help to Grow - REAL 9
The purpose of this study is to find out if somapacitan is safe and how well somapacitan works in children either born small for gestational age or with Turner syndrome, Noonan syndrome or idiopathic short stature.
- Conditions
- SGA, Turner Syndrome, Noonan Syndrome, ISS
- Trial name
- REAL 9 (NCT05723835)
- Testing
- Somapacitan
- Where
- 18 sites in United States, Malaysia and 4 more
- Volunteers
- 47 people
- Sponsor
- Novo Nordisk A/S
Autism Spectrum Disorder, Asperger Disorder
Neurocircuitry of Autism- fMRI and Transcranial Magnetic Stimulation Studies
This study uses functional brain imaging and noninvasive brain stimulation techniques to study the brain basis of developmental disorders like Autism Spectrum Disorder and Asperger Disorder.
- Conditions
- Autism Spectrum Disorder, Asperger Disorder, Pervasive Developmental Disorder
- Trial name
- NCT01553240
- Testing
- TMS and functional MRI (Magstim)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute