Clinical trials: Development
Pulmonary Nodule, Solitary, Whole-genome Methylation Sequencing
Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
Lung cancer is the first cancer in China in terms of morbidity and mortality. The problem of early diagnosis/treatment has always been concerned.
- Trial name
- NCT05415670
- Testing
- Whole-genome Methylation Sequencing(GM-seq)
- Where
- 2 sites in China
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Geneplus-Beijing Co. Ltd.
Dental Plaque, Dental Caries
Development of a Novel Anti-caries Chewing Gum
This research study is designed to evaluate the chewing gum's ability to modulate the oral microbiome in human participants, in addition to its safety.
- Conditions
- Dental Plaque, Dental Caries, Periodontal Disease
- Trial name
- NCT05946473
- Testing
- Gum base containing xylitol and essencial oils, Gum base with no additives
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Heart Defects, Congenital, Critical Illness
Leuven Growing Into Deficit Follow-up Study
The key objective of the Leuven growing-into-deficit (GID) follow-up-study is to test the hypothesis that children with a congenital heart disease (CHD) show more neurocognitive impairment at the second follow-up at 7 years old…
- Conditions
- Heart Defects, Congenital, Critical Illness, Mental Processes, Child
- Trial name
- Leuven-GID (NCT01632813)
- Where
- Belgium
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Osteogenesis Imperfecta
A First-in-Human Study Evaluating AGA2115 in Adult Healthy Volunteers
To understand if AGA2115 is safe and well tolerated in healthy adult volunteers.
- Trial name
- NCT06086613
- Testing
- AGA2115
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Angitia Incorporated Limited
Leukemia, Myelodysplastic Syndromes
Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00454480
- Testing
- alemtuzumab, arsenic trioxide, azacitidine
- Where
- 96 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- The University of New South Wales
Growth Hormone, Recombinant, Fatty Liver
The Effect of Growth Hormone Replacement on Liver Fat
We will examine a cohort of growth hormone deficient adults starting growth hormone (GH) replacement. The purpose of this study is to determine whether GH replacement reduces the fat content of the liver.
- Trial name
- NCT00774579
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Suicide, Co-design
Development of a Digital Acceptance and Commitment Therapy Intervention for Suicide Prevention in Adults Through Co-design
Suicide is a major public health concern and there is a need for accessible and scalable interventions to support individuals experiencing suicidal thoughts.
- Conditions
- Suicide, Co-design, Suicide Prevention
- Trial name
- NCT07733596
- Testing
- Digital ACT Intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Autism Spectrum Disorder
Cannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD)
This trial aims to study the efficacy and safety of cannabidivarin (CBDV) in children with ASD.
- Trial name
- NCT03202303
- Testing
- Cannabidivarin
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Montefiore Medical Center
Endovascular Therapy, Neurological Complications
Nurse-Led Predictive Protocol Cuts Neuro-Endovascular Complications
The goal of this prospective cohort study was to develop and test a 12-item, nurse-led predictive checklist that can quickly identify patients at high risk for neurological complications (bleeding, re-blockage, brain swelling…
- Trial name
- NCT07304973
- Testing
- predictive checklist
- Where
- China
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Metastatic Beast Cancer
EORTC Metastatic Breast Cancer Module Development
The overall aim of this project is to help improve the Health Related Quality of Life (HRQOL) of metastatic breast cancer (MBC) patients.
- Trial name
- NCT07806266
- Where
- 22 sites in Belgium, Canada and 12 more
- Volunteers
- 568 people
- Sponsor
- University of Leeds
Alzheimer's Disease, Dementia
Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Study
The Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Study will establish an open-label, longitudinal cohort study to assess the impact of amyloid PET on patient outcomes.
- Conditions
- Alzheimer's Disease, Dementia, Mild Cognitive Impairment
- Trial name
- IDEAS (NCT02420756)
- Testing
- PET Scan
- Where
- 2 sites in United States
- Volunteers
- 18,488 people
- Sponsor
- American College of Radiology
Osteogenesis Imperfecta
An Efficacy and Safety Trial of Intravenous Zoledronic Acid in Infants Less Than One Year of Age, With Severe Osteogenesis Imperfecta
The investigators have currently finished conducting an international multi-center trial that compares the efficacy and safety of pamidronate and zoledronate in the treatment of moderate to severe forms of Osteogenesis Imperfecta…
- Trial name
- INFOI (NCT00982124)
- Testing
- Zoledronic Acid
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Shriners Hospitals for Children
Renal Dialysis, Hemodynamics
The LIPMAT Study: Liposomal Prednisolone to Improve Hemodialysis Fistula Maturation
This study will investigate if liposomal prednisolone is effective in promoting arteriovenous fistula (AVF) maturation when administered to human subjects after surgical creation of a radio-cephalic AVF.
- Conditions
- Renal Dialysis, Hemodynamics, Vascular Remodeling, Neointima
- Trial name
- LIPMAT (NCT02495662)
- Testing
- PEG-liposomal prednisolone sodium phosphate
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Depression, Mania
Impact of Closely Grouped, Iterative Exposures to Suxamethonium During ECT on the Sensitization to NMBA and the Development of Protective Antibodies
Acute per-anesthetic hypersensitivity reaction (HSA-PA) is a rapidly occurring systemic reaction following injection of a drug during anesthesia (mortality between 3 and 9%).
- Conditions
- Depression, Mania, Hallucinations
- Trial name
- SismoSens (NCT05210062)
- Testing
- Iterative exposure to suxamethonium during ECT sessions
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Child Development
Alliance for Family Strengthening: Improved Early Childhood Development in Rwanda
Preliminary pilot testing of the home-based FSI-ECD intervention as delivered by community based lay workers.
- Trial name
- FSI-ECD (NCT03455127)
- Testing
- FSI ECD
- Where
- Rwanda
- Volunteers
- 90 people
- Sponsor
- Boston College
Allergy, Gastrointestinal Function
Can Supplementation With Lactobacillus Reuteri and Omega-3 Fatty Acids During Pregnancy and Lactation Reduce the Risk of Allergic Disease in Infancy?
The incidence of allergic disease has increased worldwide during the last decades. Initially, a lot of effort has been put in elucidating which of the known risk factors commonly associated to the development of allergic disease…
- Trial name
- PROOM-3 (NCT01542970)
- Testing
- Omega-3 fatty acids, Refined coconut and peanut oil without L. reuteri, L. reuteri
- Where
- Sweden
- Volunteers
- 496 people, healthy volunteers welcome
- Sponsor
- Ostergotland County Council, Sweden
Focal Dermal Hypoplasia
Growth Arrest in Focal Dermal Hypoplasia
Focal dermal hypoplasia (FDH) is a rare genetic disorder of ectodermal dysplasia caused by mutation in the Porcupine Homolog (Drosophila) (PORCN) gene which results in skin, hair, limb and eye abnormalities.
- Trial name
- NCT02463656
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Feeding Disorder, Autism Spectrum Disorder
The Effect Of Occupational Therapy On Sensory-Based Feeding Problems
Feeding problems are common in individuals with Autism Spectrum Disorder (ASD).This study was planned to investigate the effect of occupational theraphy on sensory feeding problems in ASD.
- Conditions
- Feeding Disorder, Autism Spectrum Disorder, Sensory Integration Disorder (Disorder)
- Trial name
- NCT03820869
- Testing
- Family Training, Occupational Therapy
- Volunteers
- 18 people
- Sponsor
- Hacettepe University
Self Efficacy, Infant Development
Connecting Families to Improve Parental Self-efficacy and Parent Psychosocial and Infant Health Outcomes in the NICU
Preterm infants, 1 in 12 Canadian births, are at a significant increased risk of poor health outcomes, resulting in high healthcare burden.
- Conditions
- Self Efficacy, Infant Development, eHealth, Mental Health Wellness 1
- Trial name
- NCT05853666
- Testing
- CNH+
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Osteogenesis Imperfecta
Dental Malocclusion and Craniofacial Development in OI
Osteogenesis imperfecta (OI) is a rare inherited disorder that causes bones to break easily. Individuals with osteogenesis imperfecta break bones often and may have other problems, including hearing loss and pain and difficulty…
- Trial name
- NCT02934451
- Where
- 3 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- Baylor College of Medicine