Clinical trials: Development, Human
Adult Growth Hormone Deficiency, Growth Hormone Disorder
A Trial to Compare the Safety of Once Weekly Dosing of Somapacitan With Daily Norditropin® FlexPro® for 26 Weeks in Previously Human Growth Hormone Treated Adults With Growth Hormone Deficiency
This trial is conducted in Europe and Asia. The aim of the trial is to compare the safety of once weekly dosing of somapacitan (administered with an investigational pen) with daily Norditropin® FlexPro® (somatropin delivered…
- Trial name
- REAL 2 (NCT02382939)
- Testing
- somapacitan, somatropin
- Where
- 28 sites in Denmark, France and 4 more
- Volunteers
- 92 people
- Sponsor
- Novo Nordisk A/S
Growth Hormone Deficiency (GHD)
Safety, PK/PD (Pharmacokinetics/Pharmacodynamics) and Efficacy of ACP-001 Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD)
A six month study of ACP-001, a long-acting growth hormone product, versus standard human growth hormone therapy. ACP-001 will be given once-a-week, standard human growth hormone (hGH) will be given on a daily basis.
- Trial name
- NCT01947907
- Testing
- ACP-001, Human Growth Hormone
- Where
- 36 sites in Belarus, Bulgaria and 12 more
- Volunteers
- 53 people
- Sponsor
- Ascendis Pharma A/S
IVF Outcomes
HELIOS: Human Embryo Illumination to Enhance Development
Embryos need a lot of energy to grow, but as women get older, the "power plants" of the cells (called mitochondria) don't work as well. This makes it harder for embryos to develop normally.
- Trial name
- HELIOS (NCT07311928)
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Influenza, Influenza Immunisation
Development of Childhood Anti-Influenza Immunity
This study is a prospective surveillance of the immune response to seasonal vaccination in healthy children. The study will enroll a total of approximately 220 subjects.
- Trial name
- NCT03673345
- Testing
- Influenza Virus Quadrivalent Inactivated Vaccine
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Challenge Model for Assessment of Human TB Immunity
This is a Phase I open-label, dose escalation trial to evaluate the use of Tice® BCG as a challenge for future assessment of in vivo TB immunity.
- Trial name
- NCT01868464
- Testing
- BCG TICE strain
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervical Cancer
Innovation for Standard Identification of Insertional HPV Mutations and of Target Therapeutic Genes in Cervical Cancer: Towards Development of Personalized Biomarkers in Clinical Oncology (PAIR HPV)
Quantification and follow-up of circulating tumoral DNA in serum and/or plasma of patients with cervical cancer compared to the early detection of minimal metastatic disease.
- Trial name
- PAIR HPV (NCT02554565)
- Testing
- Tumor biopsy, Blood sampling
- Where
- 4 sites in France
- Volunteers
- 26 people
- Sponsor
- Institut Curie
Infertility, Reproduction
Molecular Markers of Human Sperm Function
Objectives: Male factor infertility is poorly understood and our ability to evaluate the male contribution to a couple's infertility is very limited.
- Conditions
- Infertility, Reproduction, Reproductive Techniques, Assisted
- Trial name
- NCT00767611
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Autism, Autism Spectrum Disorder
Comparing Imitation and Stereotyped Behaviors in Autistic Children: Robots vs. Human Operators
Virtual QT is a social robot designed to interact with humans in social and educational contexts. Equipped with visual and vocal interfaces, the robot can recognize and respond to various human inputs, providing emotional support…
- Trial name
- NCT06144528
- Testing
- QT robot
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Autism
Synthetic Human Secretin in Children With Autism
The purpose of the study is to determine whether multiple doses of secretin are safe and effective in the treatment of children with autism.
- Trial name
- NCT00036244
- Testing
- RG1068 (Synthetic Human Secretin)
- Where
- 15 sites in United States
- Sponsor
- Repligen Corporation
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Sequential Therapy for Hypogonadotropic Hypogonadism
The traditional therapy for induction of spermatogenesis in male hypogonadotropic hypogonadism requires both HCG and human menopausal gonadotropin (HMG) or FSH until pregnancy occurs.
- Trial name
- NCT01403532
- Testing
- Traditional intervention for HH using HCG and FSH, Sequential intervention for HH using HCG and FSH, Sequential intervention for HH using HCG and FSH plus zinc
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Anxiety, Pain
Effect of Augmented Reality on Dental Anxiety and Pain Perception in Children
The aim of this study is to reduce dental anxiety in children by using augmented reality (AG) with a special content and innovative interactive methods, to determine the level of stress experienced by patients during dental…
- Trial name
- NCT06530654
- Testing
- Distraction by dentist, Distraction by cartoon movie, AG-active distraction group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Growth Hormone Deficiency Without Epiphyseal Closure
Ngenla Subcutaneous Injection Special Investigation
The purpose of this study is to learn about the long-term safety and effects of Ngenla. Ngenla is approved for treatment of GHD (Growth hormone deficiency) without epiphyseal closure under daily medical practice.
- Trial name
- NCT05602766
- Testing
- NGENLA (Somatrogon)
- Where
- Japan
- Volunteers
- 1 people
- Sponsor
- Pfizer
Human Papilloma Virus Infection
Standard Operating Procedures for Anti-HPV (Human Papillomavirus) Antibody Detection in First-void Urine
The aim of the study is to develop and implement robust analytical protocols for first-void urine sample preparation and antibody assays to monitor vaccine induced immunity against HPV (Human Papillomavirus).
- Trial name
- ABSOP-FollowUp (NCT03542227)
- Testing
- First-void urine collection, Blood draw
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Off-spring Cancer Risk
Parental One-carbon Folate and Choline Nutrition Modulates Risk of Off-spring Cancer Development: Human Cohort Study
Parental one-carbon nutrient intake (folic acid and choline) and the genetic polymorphisms of one-carbon metabolic enzyme were interact with regulating embryonic one-carbon metabolic environment, affect fetal DNA and RNA…
- Trial name
- NCT02266641
- Testing
- nutrition counseling, multivitamin supplement
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18
Development of a Self-collection Device for Cervical Cancer Screening
Evaluation of a novel self-collection device for cervical cancer screening.
- Conditions
- Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18, Human Papilloma Virus
- Trial name
- NCT05669911
- Testing
- Teal Health Self-Collection Device Group
- Where
- 6 sites in United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Teal Health, Inc.
Embryonic Development, Pregnancy
Pregnancy Rates in IVF After Ovulation Triggering With Recombinant or Urinary Human Chorionic Gonadotrophin (HCG)
To access whether the ovulation triggering with rec-HCG instead urinary-HCG has any impact on the blastulation rate and pregnancy rate of patients undergoing IVF treatment
- Conditions
- Embryonic Development, Pregnancy, VEGF
- Trial name
- NCT00954265
- Testing
- 10000 IU urinary HCG, 250 mcg recombinant HCG
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Tachykinin and Kisspeptin Expression in Human Granulosa and Cumulus Cells
The purpose of this project is to study the presence of expression differences - at RNA and protein level - of different members of the tachykinin family and kisspeptin and their receptors, between fertile women and infertile…
- Trial name
- NCT02877992
- Testing
- Ovarian puncture
- Where
- 2 sites in Spain
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Vida Recoletas Sevilla
Breastfeeding, Exclusive
Avocado Consumption, Nutrients in Human Milk, and Infant Cognitive Development
The goal of this interventional study is to establish a whole food, avocado, as a viable study material to supplement mothers and infants with nutrients that support optimal brain development.
- Trial name
- NCT06208085
- Testing
- Avocado
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Morquio Disease
Establishment of Human Cellular Disease Models for Morquio Disease
Establishment of human cellular disease models for Morquio disease for an individualized therapy development having the capacity to address both hepatic and neurologic forms of the disease
- Trial name
- IPSMORQUIO (NCT03872713)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- CENTOGENE GmbH Rostock
Positive Parenting, Child Maltreatment
Parenting in the Preschool System in Malaysia
This study aims to evaluate the effectiveness of a hybrid human-digital playful parenting programme, "Naungan Kasih-Hybrid (NK-Hybrid)", in Malaysia.
- Conditions
- Positive Parenting, Child Maltreatment, Child Development, Child Behavior
- Trial name
- NCT07599566
- Testing
- Naungan Kasih Positive Parenting Programme
- Where
- Malaysia
- Volunteers
- 772 people, healthy volunteers welcome
- Sponsor
- University of Oxford