Clinical trials: Deterioration, Clinical
Pulmonary Embolism and Thrombosis, Deterioration, Clinical
An Observational Study About Adverse Outcomes in Acute Pulmonary Embolism Patients
This multi-center retrospective study collected clinical, laboratory, and CT pulmonary angiography parameters with acute pulmonary embolism patients from admission to predict adverse outcomes within 30 days after admission into…
- Trial name
- NCT05481242
- Testing
- retrospective observational study
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shengjing Hospital
Postoperative Complications, Deterioration, Clinical
Observational Study of Early Postoperative Deterioration and Complications
This prospective observational research project aims to investigate how vital sign deterioration and complications within the (PACU) relate to early deterioration and complications in the surgical wards 72 hours post-PACU…
- Conditions
- Postoperative Complications, Deterioration, Clinical, Postoperative Care, Anesthesiology
- Trial name
- NCT06013891
- Where
- Denmark
- Volunteers
- 240 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Clinical Deterioration
Clinical Outcomes After Implementation of COntinuous Vital Sign Monitoring On the General Ward.
In 2018, continuous monitoring (CM) of 5 vital signs with a wearable device, including automated MEWS calculation within the EMR were introduced on the surgical and internal medicine ward of our hospital.
- Trial name
- COCOMO (NCT04189653)
- Testing
- Continuous Monitoring
- Where
- Netherlands
- Volunteers
- 3,896 people
- Sponsor
- Radboud University Medical Center
Clinical Deterioration
Clinical Deterioration Early Warning System Score
At present, there is no universal early warning system implemented in all Basque hospitals, but there are previous experiences, sometimes based on models generated in other health systems.
- Trial name
- CDEWS (NCT06499376)
- Where
- Spain
- Volunteers
- 20,000 people
- Sponsor
- Hospital Galdakao-Usansolo
Sepsis, Deterioration, Clinical
Outcomes of Digital Alerting Systems in Secondary Care
Why? The investigators are trying to find out if participants that suddenly deteriorate on the ward can be identified sooner by wearing a wearable sensor.
- Trial name
- NCT04638738
- Testing
- SensiumVitals wearable patch sensor
- Where
- United Kingdom
- Volunteers
- 650 people
- Sponsor
- Imperial College London
Early Clinical Deterioration
Early Warning Systems, Risk of Early Clinical Deterioration
Primary purpose of the study was to evaluate the relationship between "NEWS" and "VIEWS" scores of patients who were screened retrospectively, early clinical deterioration, return to intensive care and morbidity / mortality.
- Trial name
- NCT03912701
- Testing
- Vitalpac early warning score (VIEWS)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Erzincan University
Pulmonary Disease, Chronic Obstructive
Calprotectin I Serum as a Diagnostic Marker
Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03474484
- Where
- Norway
- Volunteers
- 113 people
- Sponsor
- St. Olavs Hospital
ARDS
Safety and Efficacy of EXO-CD24 in Preventing Clinical Deterioration in Patients With Mild-Moderate ARDS
This is phase IIb, Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Safety and Efficacy of Exosomes Overexpressing CD24 of one dose 10^10 exosome particles, to Prevent Clinical Deterioration in Patients with…
- Trial name
- NCT05947747
- Testing
- EXO-CD24
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Nano24med
Aortic Valve Stenosis, Structural Valve Deterioration
Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication
The VIVALL-2 study is a randomized trial to compare the self-expandable supra-annular Allegra and the balloon-expandable intra-annular Edwards transcatheter valve systems in patients with degenerated biological aortic surgical…
- Trial name
- NCT06049654
- Testing
- NVT ALLEGRA TAVI System TF, EDWARDS SAPIEN 3 or SAPIEN ULTRA SYSTEM
- Where
- 12 sites in Italy, Spain and 1 more
- Volunteers
- 104 people
- Sponsor
- Fundación EPIC
Covid19
Safety and Efficacy of Exosomes Overexpressing CD24 in Two Doses for Patients With Moderate or Severe COVID-19
This is a phase II randomized, single-blind dose study to evaluate the safety and efficacy of exosomes overexpressing CD24 of two doses, Dose 1 - 10^9 exosome particles (per dose) versus Dose 2 - 10^10 exosome particles (per…
- Trial name
- NCT04902183
- Testing
- CovenD24
- Where
- 3 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Athens Medical Society
Clinical Deterioration
Predicting ICU Transfers and Other Unforeseen Events (PICTURE)-Pediatric
The purpose of this study is to evaluate the effectiveness and user satisfaction of the study teams early warning system, called PICTURE, which utilizes artificial intelligence (AI) techniques and algorithms to identify patient…
- Trial name
- NCT07304050
- Testing
- PICTURE-Pediatric scores and alerts, Control Arm - Scores and alerts hidden
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- University of Michigan
Respiratory Insufficiency, Clinical Deterioration
Wearable Wireless Respiratory Monitoring System That Detects and Predicts Opioid Induced Respiratory Depression
An observational study will be conducted in approximately 14 participants to evaluate the ability of a wearable, wireless acoustic Respiratory Monitoring System (RMS) to accurately measure a participant's respiratory rate, tidal…
- Trial name
- NCT06442488
- Testing
- Respiratory Monitoring System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jeffrey Joseph
Monitoring, Clinical Deterioration
Continuous Monitoring of Patients in and After the Acute Admission Ward to Optimize Clinical Pathways
Hospitals aim to hospitalize patients when necessary and discharge patients when possible. However, the triage process and discharge management of patients in e.g. the Acute Admission Ward, is not a trivial task.
- Conditions
- Monitoring, Clinical Deterioration, Acute Disease
- Trial name
- NCT05181111
- Testing
- Wearable Sensor, Usual Care
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Rijnstate Hospital
Coronavirus Infection
STerOids in COVID-19 Study
At the time of writing (3/4/2020), close to a million people have been infected by the SARS-CoV-2 coronavirus around the world. The severe clinical condition that leads to deaths is now called CoVID-19.
- Trial name
- STOIC (NCT04416399)
- Testing
- Budesonide dry powder inhaler
- Where
- United Kingdom
- Volunteers
- 146 people
- Sponsor
- University of Oxford
Early Warning Score, Monitoring
Observational Study Evaluating the viQtor for Early Detection of Clinical Deterioration in Post-ICU Patients on General Wards
Rationale Following ICU discharge, intermittent vital sign monitoring may delay timely recognition of clinical deterioration and lead to unnecessary readmissions.
- Conditions
- Early Warning Score, Monitoring, Telemedicine-Based Education, Readmission
- Trial name
- ViQtor (NCT06815718)
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Erasmus Medical Center
Deterioration, Clinical
Feasibility and Initial Clinical Impressions of Predictive Monitoring Integrated With the RACE Team
Rapid response teams (RRTs) have been adopted by hospitals to provide urgent critical care to hospitalized patients who require quick intervention to prevent further deterioration.
- Trial name
- VSI (NCT05108376)
- Testing
- Visensia Safety Index (VSI)
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Ottawa Hospital Research Institute
Cerebral Infarction, Subcortical Infarction
Early Neurological Deterioration in Recent Small Subcortical Infarction
Recent small subcortical infarction (RSSI) is defined as a small deep infarction in the territory of a perforating artery with maximum axial diameters (MAD) of less than 20 mm.
- Conditions
- Cerebral Infarction, Subcortical Infarction, Deterioration, Clinical, Progression
- Trial name
- NCT05679986
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Yuan Gao
Irritable Bowel Syndrome
Predictive Factors for a Clinical Diagnosis of Irritable Bowel Syndrome in a Large Cohort of Young Adults.
The prevalence of IBS in the community has been reported in numerous cross-sectional surveys. However, less is known about the incidence of IBS ,mainly due to its slow development and to patients under-reporting.
- Trial name
- NCT01854060
- Where
- Israel
- Volunteers
- 440,822 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Covid19
Early Detection of Clinical Deterioration in Patients With COVID-19 Using Machine Learning
The aim of this study is to use artificial intelligence in the form of machine learning analysing vital signs as well as symptoms of patients suffering from Covid19 to identify predictors of disease progression and severe course…
- Trial name
- COVID-19 (NCT04828915)
- Testing
- Machine learning, Machine based evaluation
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital Tuebingen
Schizophrenia, Schizo-Affective Disorder
Correlation Between Clinical Deterioration in Schizophrenic Patients and Hair Cortisol Levels
The importance of stress as a possible deteriorating factor for schizophrenic patients is well documented. However, this notion is based on subjective experience and retrospective psychological analysis.
- Trial name
- NCT01754532
- Testing
- Hair Sample
- Where
- Israel
- Volunteers
- 34 people
- Sponsor
- Shalvata Mental Health Center