Clinical trials: Deterioration, Clinical
Rheumatoid Arthritis
The Relation Between Dedicated Extremity MRI Synovitis and Structural Deterioration Radiographic in Patients With Rheumatoid Arthritis in Clinical Remission. Preliminary Study
The major aim of treatment for rheumatoid arthritis is remission. Nevertheless, structural radiographic progression is observed in 15 to 20% of patient getting remission.
- Trial name
- NCT01050010
- Testing
- MRI
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Inpatient Facililty Diagnoses
Wireless Monitoring for Clinical Deterioration
The study evaluates whether implementing a wireless monitoring system for patients admitted to hospital wards reduces mortality and cardiopulmonary failure.
- Trial name
- i-PROTECT (NCT06644599)
- Testing
- wireless monitoring
- Where
- Saudi Arabia
- Volunteers
- 13,160 people
- Sponsor
- King Abdullah International Medical Research Center
Vital Sign, Clinical Deterioration
WARD-Home - Continuous Monitoring of Vital Parameters After Discharge
The current pilot study aims to investigate the feasibility of wireless, continuous monitoring of patients in the days around discharge after an acute medical hospitalization, as well as occurrence of deviating vital signs in…
- Trial name
- NCT05223504
- Testing
- Continuously monitoring
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Clinical Reasoning in Nursing Education, Virtual Simulation
MAGICS - Multi-Agent Generative AI in Clinical Simulation for Clinical Deterioration Training
This study compares the effectiveness of a Generative AI-integrated blended simulation programme and high-fidelity simulation alone on nursing students' clinical reasoning and learning experience during deterioration training
- Conditions
- Clinical Reasoning in Nursing Education, Virtual Simulation, Artificial Intelligence in Education, Deterioration, Clinical
- Trial name
- MAGICS (NCT07872735)
- Testing
- Generative AI-integrated Blended Simulation, High Fidelity Simulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Pulmonary Embolism and Thrombosis, Deterioration, Clinical
Adverse Outcome of Acute Pulmonary Embolism by Artificial Intelligence System Based on CT Pulmonary Angiography
The investigators aim to build a predictive tool for Adverse Outcome of Acute Pulmonary Embolism by Artificial Intelligence System Based on CT Pulmonary Angiography.
- Conditions
- Pulmonary Embolism and Thrombosis, Deterioration, Clinical, Artificial Intelligence
- Trial name
- PEAICTPA (NCT05482269)
- Testing
- no intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shengjing Hospital
Cerebral Venous Thrombosis
Clinical Deterioration in Cerebral Venous Thrombosis: A Predictive Study
The objective of this retrospective, prospective, multicenter cohort study is to determine the risk factors for deterioration of CVT patients after admission and establish a scoring model for risk stratification of patients.
- Trial name
- NCT06266585
- Where
- China
- Volunteers
- 273 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Clinical Study on Screening of Nursing Evaluation Indicators of Stroke Patients
The purpose of this study was to use Delphi method to screen the nursing observation indexes of patients with stroke, and to screen the sensitive indexes with high correlation with the severity of stroke.It is used to guide…
- Trial name
- NCT03650751
- Testing
- Nursing observation indexes
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shenzhen Second People's Hospital
Pulmonary Disease, Chronic Obstructive
Calprotectin I Serum as a Diagnostic Marker
Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03474484
- Where
- Norway
- Volunteers
- 113 people
- Sponsor
- St. Olavs Hospital
Dementia of the Alzheimer Type, Age-related Cognitive Decline
Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration
DEPEND is an open-label but dosage-masked trial of the retired cholesterol-lowering drug probucol as an agent to increase availability of apolipoprotein E (apoE) in the cerebrospinal fluid (CSF) of cognitively intact older…
- Conditions
- Dementia of the Alzheimer Type, Age-related Cognitive Decline, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- DEPEND (NCT02707458)
- Testing
- Probucol
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Undefined
CSAPG Early Warning Score
The Early Warning Score (EWS) has been shown in previous studies to be correlated with mortality and mean hospital stay, but it is unknown whether the implementation of the scale improves mortality and mean hospital stay.
- Trial name
- CEWS (NCT04905095)
- Testing
- EWS, usual clinical care
- Where
- Spain
- Volunteers
- 15,998 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Continuous Wireless Vital Parameter Monitoring
Continuous Monitoring of Vital Parameters for Early Detection of Clinical Deterioration in Hospitalized Patients
For patients admitted to the medical ward, it is often difficult to predict if their clinical condition will deteriorate, however subtle changes in vital signs are usually present 8 to 24 hours before a life-threatening event…
- Trial name
- WARD (NCT04305262)
- Testing
- Wireless continuous vital parameter monitoring
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Non-small Cell Lung Cancer, Remote Monitoring
ETERNALS: Remote Monitoring in Lung Cancer Patients
The primary objective of this project is to determine the feasibility of an integrated remote monitoring system in the routine care of lung cancer patients receiving cytotoxic chemotherapy.
- Conditions
- Non-small Cell Lung Cancer, Remote Monitoring, Mobile Health, Chemotherapy Effect
- Trial name
- ETERNALS (NCT06479005)
- Testing
- Oura Ring
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Ziekenhuis Oost-Limburg
Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute
Repeated Examinations for Typing Pulmonary Embolism
PURPOSE The two related purposes of the RE-TyPE study are: 1. To improve understanding of the early clinical course of intermediate-high risk pulmonary embolism and its association with outcome and 2.
- Conditions
- Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute, Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism With Right Ventricle Enlargement
- Trial name
- RE-TyPE (NCT07491094)
- Where
- 3 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Sahlgrenska University Hospital
Sepsis, Patient Deterioration
UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial
This study is designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (cardiac arrest, death…
- Trial name
- NCT06779617
- Testing
- SEPSys, RESCUE
- Where
- 8 sites in United States
- Volunteers
- 150,000 people
- Sponsor
- University of Maryland, Baltimore
Structural Valve Deterioration, Structural Valve Degeneration
The ReTAVI Prospective Observational Registry
Patients with severe aortic stenosis (sAS) treated with transcatheter aortic valve implantation (TAVI) (increasingly younger \& lower risk pts) are experiencing SVD of the index THV and thus developing an indication for a…
- Conditions
- Structural Valve Deterioration, Structural Valve Degeneration, Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction
- Trial name
- NCT05601453
- Testing
- Elective redo transcatheter aortic valve implantation (redo-TAVI)
- Where
- 62 sites in Austria, Canada and 9 more
- Volunteers
- 250 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Acute Disease, Disease Progression
Multimodal Digital Biomarker Prediction of Acute Clinical Deterioration
Rather than relying on a single abnormal vital sign, the study will examine how multiple physiologic signals change together over time and whether changes in the relationships among these signals provide useful information about…
- Conditions
- Acute Disease, Disease Progression, Critical Illness, Biomarkers
- Trial name
- FUSION-72 (NCT07817550)
- Testing
- Multimodal Digital Biomarker Monitoring
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Truway Health, Inc.
Pulmonary Embolism and Thrombosis, Deterioration, Clinical
An Observational Study About Adverse Outcomes in Acute Pulmonary Embolism Patients
This multi-center retrospective study collected clinical, laboratory, and CT pulmonary angiography parameters with acute pulmonary embolism patients from admission to predict adverse outcomes within 30 days after admission into…
- Trial name
- NCT05481242
- Testing
- retrospective observational study
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shengjing Hospital
Mitral Valve Disease
Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery
The objective of this study is to collect in a prospective registry all cases of French patients undergoing an assessment for percutaneous treatment of mitral valve disease on a native valve or due to deterioration after surgical…
- Trial name
- MITRAGISTER (NCT02925819)
- Where
- 3 sites in France
- Volunteers
- 500 people
- Sponsor
- French Cardiology Society
Sepsis, Septicemia
A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
In this study, the investigators will deploy a software-based clinical decision support tool (eCARTv5) into the electronic health record (EHR) workflow of multiple hospital wards.
- Conditions
- Sepsis, Septicemia, Respiratory Failure, Hemodynamic Instability
- Trial name
- NCT05893420
- Testing
- eCARTv5 clinical deterioration monitoring, Standard of care control
- Where
- 3 sites in United States
- Volunteers
- 30,000 people
- Sponsor
- AgileMD, Inc.
Irritable Bowel Syndrome
Predictive Factors for a Clinical Diagnosis of Irritable Bowel Syndrome in a Large Cohort of Young Adults.
The prevalence of IBS in the community has been reported in numerous cross-sectional surveys. However, less is known about the incidence of IBS ,mainly due to its slow development and to patients under-reporting.
- Trial name
- NCT01854060
- Where
- Israel
- Volunteers
- 440,822 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force