Clinical trials: Depression in Adults
Dementia, Neurocognitive Disorders
Cognitive Stimulation in Older Adults With Alzheimer's Disease
This multicentre study, employing a randomised controlled repeated measures experimental design, will be conducted in several Portuguese institutions that provide care and support services for older adults diagnosed with mild to…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT07041008
- Testing
- Digital intervention, Physical/Analogue Intervention
- Where
- 39 sites in Portugal
- Volunteers
- 514 people
- Sponsor
- Rsocialform - Geriatria, Lda
Major Depressive Disorder (MDD), Major Depressive Disorder With Psychotic Features
Study of Lurasidone as Adjunctive Treatment in Patients With Major Depressive Disorder With Inadequate Response to Antidepressant Monotherapy
This Phase 3, multicenter, randomized, double-blind, placebo-controlled clinical trial is designed to evaluate the efficacy and safety of lurasidone as adjunctive therapy in adult patients with major depressive disorder (MDD) who…
- Trial name
- NCT07781293
- Testing
- Lurasidone, Background Antidepressant Therapy
- Volunteers
- 364 people
- Sponsor
- Bukwang Pharmaceutical
Middle-aged Adults, Major Depressive Disorder
Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
The goal of this pilot clinical trial is to begin to understand how day-to-day stress affects cardiovascular health and brain function in middle-aged adults.
- Trial name
- NCT06466655
- Testing
- MitoTempol, Lactated Ringer's (control)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Depressive Disorder
Efficacy of Acceptance and Commitment Therapy on Serum GDF-15 Levels in Older Adults With and Without Depression: a Non-randomized Intervention Study
In a world where the population is aging, strategies are required that promote physical, social and mental health in these age groups.
- Trial name
- ACT GDF-15 (NCT06195436)
- Testing
- Acceptance and Commitment Therapy for people with and without depression
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Bipolar Depression
A Preliminary Study of the Effectiveness and Tolerability of Aripiprazole in Bipolar Depression
The specific aim of this study is to obtain preliminary evidence of the acute effectiveness and tolerability of aripiprazole in the treatment of bipolar depression.
- Trial name
- NCT00363337
- Testing
- aripiprazole
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Lindner Center of HOPE
Depressive Disorder, Major
Efficacy of Lu AA21004 on Cognitive Dysfunction in Major Depressive Disorder
The purpose of this study is to evaluate the effects of Lu AA21004, once daily (QD), on cognitive dysfunction in patients with major depressive disorder.
- Trial name
- NCT01564862
- Testing
- vortioxetine (Lu AA21004), Duloxetine
- Where
- 92 sites in United States, Bulgaria and 5 more
- Volunteers
- 602 people
- Sponsor
- Takeda
Respiratory Depression
Effects of Sequential Exposure to Nitrogen Dioxide and Ozone in Healthy Adult Human Volunteers.
The U.S. Environmental Protection Agency has traditionally examined the effects of single pollutant exposure on human health outcomes; however, to provide a better assessment of pollutant exposure-associated effect on human…
- Trial name
- ENDZONE (NCT02133586)
- Testing
- Ozone, Nitrogen dioxide
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Emotional Disorders, ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)
Effectiveness of the Group Unified Protocol for Emotional Disorders in Adults in a Public Mental Health Setting
This study has three primary objectives: 1. To adapt the Spanish version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al., 2011, 2019a, 2019b) for delivery in a group format within…
- Conditions
- Emotional Disorders, ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Depressive Disorder, Somatic Disorders
- Trial name
- PSIGTE (NCT07682064)
- Testing
- UP, TAU
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Patricia Fernández Couto
Depression, Anxiety
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health
Ketamine-Assisted Psychotherapy (KAP) is a relatively new approach for the treatment of mental health issues, which involves the combination of ketamine, a dissociative anaesthetic with psychedelic properties, and psychotherapy…
- Conditions
- Depression, Anxiety, Post Traumatic Stress Disorder
- Trial name
- NCT05604794
- Testing
- Ketamine-Assisted Psychotherapy (KAP)
- Where
- 11 sites in United States, Canada
- Volunteers
- 1,806 people
- Sponsor
- Field Trip Health
Autism, Depression
Adapting BA for Minimally Verbal Autistic Adults
The present study aims to adapt and evaluate the feasibility of the BeatIt-2 behavioral activation intervention for people with intellectual disabilities and low mood to be implemented with minimally verbal autistic individuals.
- Conditions
- Autism, Depression, Autism Spectrum Disorder With Impaired Functional Language, Autism Spectrum Disorder
- Trial name
- NCT06064422
- Testing
- BeatIt-MV
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rutgers, The State University of New Jersey
Major Depressive Disorder, Loneliness
Treating Loneliness In The Older Adult With Depression With tDCS
High loneliness is prevalent among older adults and is a significant risk factor for major depression and low recovery rates in patients. Current interventions for loneliness are limited.
- Trial name
- NCT06658795
- Testing
- Transcranial direct current stimulation (tDCS) on the Left DLPFC, Transcranial direct current stimulation (tDCS) on the right VLPFC
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital