Clinical trials: Depression in Adults
Major Depressive Disorder, Cardiovascular Diseases
Emotion Regulation Training to Reduce Cardiovascular Disease Risk Among Depressed Young Adults in Southern Mississippi
The proposed study will investigate the utility of a single-session emotion regulation training to reduce CVD risk among young adults diagnosed with MDD living in Southern MS.
- Conditions
- Major Depressive Disorder, Cardiovascular Diseases, Inflammation, Blood Pressure
- Trial name
- NCT05425290
- Testing
- Single-session emotion regulation training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern Mississippi
Depression - Major Depressive Disorder, Depressive Episodes
TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children
Depression in childhood and adolescence is a serious and increasing public-health problem associated with profound short- and long-term consequences, including impaired social and educational functioning, increased risk of…
- Trial name
- NCT07478796
- Testing
- Fluoxetine, Escitalopram, Sertralin
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Poznan University of Medical Sciences
Major Depressive Disorder
Study Evaluating Desvenlafaxine Sustained-Release (DVS-SR) in Adult Outpatients With Major Depressive Disorder
The purpose of this study is to compare the antidepressant efficacy, safety, and tolerability of DVS-SR in subjects receiving daily doses of 50 mg or 100 mg of DVS-SR versus subjects receiving placebo.
- Trial name
- NCT00277823
- Testing
- DVS-SR 50 mg, DVS-SR 100 mg
- Where
- 25 sites in United States
- Volunteers
- 480 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depressive Symptoms
Effects of a Blended Indoor and Outdoor Physical Exercise Program on Depressive Symptoms in Hong Kong Older Adults
Depression is a mental health problem often occurring in the elderly. Performing physical exercise is a key element in decreasing depressive symptoms in older adults.
- Trial name
- NCT06190327
- Testing
- Blended indoor and outdoor multicomponent structured exercise, Indoor-only multicomponent structured exercise
- Where
- Hong Kong
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Depression
Comparison Study of Family Practice Interventions for Depression in Adults
To determine if treatment of significant depressive symptoms identified in individuals attending a family practice improves either psychiatric outcome, overall health care costs, or Quality of Life (QOL).
- Trial name
- NCT01975207
- Testing
- Treatment as usual, Internet Intervention, Depression Treatment Pathway
- Volunteers
- 1,489 people, healthy volunteers welcome
- Sponsor
- AHS Cancer Control Alberta
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors
RATIONALE: Methylphenidate may decrease side effects of radiation therapy. It is not yet known if methylphenidate is effective in improving quality of life in patients with primary or metastatic brain tumors.
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Depression, Fatigue
- Trial name
- NCT00031798
- Testing
- methylphenidate hydrochloride, quality-of-life assessment, radiation therapy
- Where
- 7 sites in United States
- Sponsor
- Wake Forest University Health Sciences
Depressive Symptoms
Computerized Cognitive Training in Young Adults With Depression
The purpose of the study is to examine the benefits and mechanism of action of computerized cognitive training (CCT) on mood, neuropsychological deficits, everyday functioning, and brain activity among young adults with a range…
- Trial name
- NCT03869463
- Testing
- Computerized Cognitive Training, Control
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Queens College, The City University of New York
Depression, Postpartum, Postpartum Depression
A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
The purpose of this research study is to test the study drug, NORA520, as a possible treatment for severe postpartum depression (PPD).
- Conditions
- Depression, Postpartum, Postpartum Depression, Post-partum Depression, Postnatal Depression
- Trial name
- NuMom (NCT06285916)
- Testing
- NORA520 Dose 1, NORA520 Dose 2
- Where
- 18 sites in United States
- Volunteers
- 93 people
- Sponsor
- TWi Biotechnology, Inc.
Anxiety, Depression
Social Factors in the Mental Health of Young Adults: Bridging Psychological and Network Analysis
The central goal of this project is to produce a novel, precise, and comprehensive account of social factors in young adult mental health - using a novel combination of network nominations, ecological momentary assessment, and…
- Conditions
- Anxiety, Depression, Loneliness, Stress
- Trial name
- NCT04771195
- Testing
- Examination of students' naturally occurring social ties
- Where
- United States
- Volunteers
- 9,941 people, healthy volunteers welcome
- Sponsor
- Stanford University
Psychological Distress
Existential Group Treatment for Older Adults (75+) With Psychological Distress in Primary Care
Symptoms of depression and anxiety are common in older adults, and high suicide rates are observed in this age group in Sweden, as in many countries around the globe.
- Trial name
- NCT05503485
- Testing
- Existential group treatment, Supportive telephone calls
- Where
- 7 sites in Sweden
- Volunteers
- 140 people
- Sponsor
- Göteborg University
Major Depressive Disorder
Efficacy and Safety of SR58611A co-Administered With Escitalopram in Adults With Major Depressive Disorder
The primary objective of the study is to compare, after 8 weeks, the efficacy of SR58611A vs. placebo in patients with Major Depressive Disorder who are on concomitant treatment with escitalopram.
- Trial name
- ALBERIO (NCT00432614)
- Testing
- SR58611A, escitalopram
- Where
- 13 sites in Belgium, Estonia and 11 more
- Volunteers
- 510 people
- Sponsor
- Sanofi
Suicide, Depression
Adaptation of a French E-health Tool for Suicide Prevention in Young Populations
"France's suicide rate is among the highest in Europe, with the young among the more at risk. Several European projects have demonstrated the effectiveness of using e-tools in suicide prevention particularly for hard-to-reach…
- Conditions
- Suicide, Depression, Psychological Distress, Anxiety Disorders
- Trial name
- E-psYouth (NCT04946955)
- Testing
- Application and website with or without promotion
- Where
- France
- Volunteers
- 12,000,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depressive Disorder, Major, Anhedonia
A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
The purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult participants with major depressive disorder (MDD) with…
- Trial name
- VENTURA-1 (NCT05455684)
- Testing
- Aticaprant
- Where
- 120 sites in United States, Argentina and 11 more
- Volunteers
- 513 people
- Sponsor
- Janssen Research & Development, LLC
Depression, Anxiety
Generative Artificial Intelligence Intervention and Individual Psychological Counseling on Emotional Distress in Young Adults
This randomized controlled trial aims to evaluate the effectiveness of an AI-based mental health chatbot, Emohaa, in reducing symptoms of depression, anxiety, insomnia, and academic burnout among young adults experiencing…
- Trial name
- NCT06992180
- Testing
- Generative Artificial Intelligence Intervention, Individual Psychological Counseling
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Central University of Finance and Economics, China
Cognitive Decline, Osteoarthritis
Healthy Body & Mind Program for Older Adults Living With Osteoarthritis and Cognitive Decline
The goal of this pilot randomised clinical trial is to compare a 12-week Healthy Body \& Mind Program to usual care in older adults living with cognitive decline and osteoarthritis.
- Trial name
- NCT06070818
- Testing
- Healthy Body & Mind Program
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- The University of New South Wales
Depression
Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
The primary objective of the study is to determine whether armodafinil treatment, at a dosage of 150 mg/day, is more effective than placebo treatment as adjunctive therapy to mood stabilizers for treatment of adults with major…
- Trial name
- NCT01072630
- Testing
- Armodafinil
- Where
- 92 sites in United States, Argentina and 8 more
- Volunteers
- 492 people
- Sponsor
- Cephalon
Major Depressive Disorder
Goal Achievement After a Change to Vortioxetine in Adults With Major Depressive Disorder
The purpose of this study is to determine the effectiveness of treatment with vortioxetine on participant goal achievement after a change in antidepressant medication for the treatment of major depressive disorder (MDD).
- Trial name
- NCT02972632
- Testing
- Vortioxetine
- Where
- 25 sites in United States
- Volunteers
- 123 people
- Sponsor
- Takeda
Major Depressive Disorder
Stress and the Sympathetic Nervous System in Adults With Depression
To test our hypotheses, we will enroll healthy adults having no history of mood disorders and adults with major depressive disorder (MDD) having a broad range of depressive symptom severity.
- Trial name
- NCT04838262
- Testing
- Acute Stressors
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Depression Disorders, Affective Disorders
Prevention of Mental Disorders Through Self-efficacy Interventions
Low self-efficacy is a transdiagnostic risk factor for several mental disorders. Self-efficacy refers to one's belief that one is capable of performing a behavior necessary to successfully complete a task or achieve a goal.
- Conditions
- Depression Disorders, Affective Disorders, Prevention, Substance Use Disorders
- Trial name
- SELFTIE (NCT06738953)
- Testing
- Cognitive-Behavioral Intervention to increase Self Efficacy
- Where
- Germany
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Health and Medical University Potsdam
Depressive Disorder, Major
Zelquistinel in the Treatment of Major Depressive Disorder
The purpose of this study is to evaluate the efficacy at 1 day post initial oral dose of zelquistinel (AGN-241751) compared with placebo in participants with Major Depressive Disorder (MDD).
- Trial name
- AGN-241751 (NCT03586427)
- Testing
- AGN-241751
- Where
- 25 sites in United States
- Volunteers
- 251 people
- Sponsor
- Syndeio Biosciences, Inc