Clinical trials: Depression, pill or tablet or capsule or oral, open to volunteers
Treatment Resistant Depression, Treatment Resistant Depression (TRD)
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
Major depressive disorder (MDD) is a significant public health problem and leading cause of worldwide disability. Treatment resistance is common in MDD, however, for these individuals, targeted noninvasive brain stimulation is an…
- Trial name
- SPARC-TMS (NCT07227103)
- Testing
- Neuronavigated robotic-enabled TMS, NRX-101
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- NeuroRx, Inc.
Major Depression
Effect of Psychobiotics With Standard Antiddepressants in Treatment of Major Depressive Disorder
The goal of this clinical trial is to learn whether adding psychobiotics (a combination of Lactobacillus helveticus and Bifidobacterium longum) to standard antidepressant treatment works better than antidepressants alone for…
- Trial name
- NCT07691749
- Testing
- Lactobacillus Helveticus and bifidobacterium Longum
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- Dr Sadia yasir
Attention-Deficit/Hyperactivity Disorder (ADHD), Depression - Major Depressive Disorder
Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe Depression
The indication of attention-deficit/hyperactivity disorder (ADHD) to be examined often occurs with other psychiatric disorders, and the majority of adults with ADHD have at least one psychiatric comorbidity in their lives.
- Trial name
- DEXAD (NCT06967857)
- Testing
- DEX IR tablets, DEX XL
- Where
- 5 sites in Germany
- Volunteers
- 105 people
- Sponsor
- Prof. Dr. Frank Behrens
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
The goal of this clinical trial is to learn if a drug called TNX-102 SL works to treat moderate to severe major depressive disorder in adults. It will also learn about the safety of TNX-102 SL.
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Depression
- Trial name
- HORIZON (NCT07621237)
- Testing
- TNX-102 SL
- Where
- 27 sites in United States
- Volunteers
- 360 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Fibromyalgia Syndrome, Fibromyalgia
Effects of 2-Aticyto Complex and D-Ribose on Pain and Clinical Course in Patients With Fibromyalgia
This multicenter, randomized, double-blind, placebo-controlled study will evaluate whether an oral supplement containing 2-Aticyto Complex and D-ribose (FibroThol), added to ongoing standard medical treatment, improves pain…
- Trial name
- NCT07495943
- Testing
- 2-Aticyto Complex and D-ribose Oral Supplement
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Outpatients or Inpatients With Depression
A Multicenter Real-World Study Evaluating the Efficacy and Safety of Shugan Jieyu Capsules in the Treatment of Depression
To observe the efficacy and safety of Shugan Jieyu Capsules in treating patients with varying degrees of depression in real-world clinical settings, and to provide data references for optimizing integrated traditional Chinese and…
- Trial name
- NCT07785284
- Testing
- Shugan Jieyu Capsules
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University
Depression / Major Depressive Disorder
Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD)
A double-blind, randomized controlled trial (RCT) aimed at evaluating the efficacy of probiotic supplementation in patients undergoing concurrent antidepressant therapy.
- Trial name
- ProMOOD (NCT07786285)
- Testing
- OMNi-BiOTiC® STRESS Repair
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Maribor
Depression - Major Depressive Disorder
Efficacy and Mechanisms of Escitalopram in Drug-Naïve First-Episode Major Depressive Disorder
The goal of this project is to quantify the effectiveness and safety of escitalopram oxalate oral solution in the treatment of first-episode, drug-naïve patients with major depressive disorder, and to explore the mechanisms…
- Trial name
- NCT07480525
- Testing
- Escitalopram (Oral antidepressant)
- Where
- 5 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University
Cognition Function, Mild Depression
Effect of Probiotic on Cognitive Function
The goal of this clinical trial is to learn if daily single-strain probiotic supplementation (Lactobacillus plantarum) works to improve cognitive function and depressive symptoms in Egyptian women aged 50-64 years with mild…
- Trial name
- NCT07776145
- Testing
- Lactobacillus plantarum
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Cairo University
Postpartum Depression (PPD)
A Study of MI078 for Postpartum Depression
This is a multicenter, randomized, double-blind, placebo-controlled trial consisting of an experimental drug group and a placebo group, each enrolling 100 participants.
- Trial name
- NCT07721961
- Testing
- MI078 capsule
- Where
- 36 sites in China
- Volunteers
- 200 people
- Sponsor
- Nanjing Minova Pharmaceutical Co., Ltd.
Major Depression Severe
Oral and Sublingual Ketamine
Major Depressive Disorder (MDD) is one of the most common and severe mental illnesses in the world. Ketamine treatment, especially intravenous ketamine (IVK) and intranasal esketamine (INE), is becoming more popular and is being…
- Trial name
- NCT07683988
- Testing
- 75 mg of oral ketamine, Sublingual ketamine 75 mg
- Volunteers
- 10 people
- Sponsor
- Western University, Canada
Oral Frailty, Depression
Group Reading and Oral Exercise Program for Older Adults
Depression is common among older adults and is often associated with declines in physical and oral health. Non-pharmacological, community-based interventions are needed to support both mental and physical well-being.
- Conditions
- Oral Frailty, Depression, Sarcopenia, Physical Function Decline
- Trial name
- NCT07550335
- Testing
- Reading and Oral Exercise Program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Depression
A Study of the Effectiveness and Safety of JS1-1-01 Tablet in Patients With Moderate to Severe Depression
The purpose of this study is to evaluate the Effectiveness and Safety of JS1-1-01 Tablet in Patients With Moderate to Severe Depression
- Trial name
- NCT07485595
- Testing
- JS1-1-01 low-dose group, JS1-1-01 high-dose group
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd
Mild Depression
Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth
The primary goal is to investigate to what extent changes in glutamate and glutathione modulation and functional integration between brain networks associated with emotion and attention regulation are associated with treatment…
- Trial name
- NAC+MIND (NCT07464886)
- Testing
- N-acetylcysteine, Mindfulness-based cognitive therapy
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Cincinnati
Anhedonia, Depression
Dopaminergic Therapy for Anhedonia - 2
The purpose of this 8-week, double-blind, placebo-controlled, study is to explore new treatment options for people with depression who have high inflammation and anhedonia.
- Trial name
- DTA-2 (NCT06075771)
- Testing
- Carbidopa Levodopa
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Emory University
Major Depressive Disorder (MDD)
tVNS, Motivation, and Insulin Sensitivity
Disturbances in energy metabolism significantly increase the risk of developing major depressive disorder (MDD), especially in individuals with type 2 diabetes.
- Trial name
- NCT07198100
- Testing
- Transcutaneous non-invasive vagus nerve stimulation (tVNS), Oral glucose tolerance test (oGTT)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Major Depressive Disorder (MDD), Depression - Major Depressive Disorder
Assessment of the Efficacy and Safety of Fecal Microbiota Transplantation (FMT) in Patients With Major Depressive Disorder
This study aimed to evaluate the efficacy and safety of fecal microbiota transplantation (FMT) in patients with major depressive disorder (MDD) who exhibit suboptimal early response to antidepressant treatment.
- Trial name
- NCT06692361
- Testing
- FMT capsule, Escitalopram (Lexapro), Corn Starch capsules
- Where
- 9 sites in China
- Volunteers
- 214 people
- Sponsor
- Gang Wang
Major Depressive Disorder, Severe Depressive Episode Without Psychotic Symptoms
The Friendship Bench Plus Trial
The goal of this randomised controlled trial is to enhance the Friendship Bench intervention with antidepressants in adults with moderate to severe depression. The main questions it aims to answer are: 1.
- Trial name
- NCT06384209
- Testing
- Fluoxetine, Sertraline Pill, Friendship Bench Intervention- Problem Solving Therapy
- Where
- Zimbabwe
- Volunteers
- 296 people
- Sponsor
- University of Bern
Major Depressive Disorder
Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression
The goal of this clinical trial is to learn how hormonal changes over the menstrual cycle affect mood symptoms in reproductive-aged women with depression that worsens during the premenstrual period.
- Trial name
- PEAR (NCT06610305)
- Testing
- Transdermal estradiol, Progesterone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Mental Acuity
Effects of Spirulina Supplementation on Mental Health in Healthy Adults
Spirulina platensis is a form of cyanobacteria, a blue-green algae, and is a superfood most known for being rich in protein, vitamins and minerals, and healthful phytochemicals.
- Trial name
- NCT06936202
- Testing
- Spirulina capsules
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Arizona State University