Clinical trials: Depressed
Post-stroke Depression
Efficacy of Accelerated Repetitive Transcranial Magnetic Stimulation on Patients With Post-stroke Depression
The FDA approved repetitive transcranial magnetic stimulation (rTMS) for patients with Major Depressive Disorder (MDD) in 2008. The conventional rTMS protocol that has been used effectively for major depression is 5 days per week…
- Trial name
- NCT06157333
- Testing
- The Magstim Rapid2 Plus Magnetic Stimulator (Magstim, Whitland, Dyfed, UK)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara City Hospital Bilkent
Depression
Depression, Adversity, and Stress Hormones (DASH) Study
The stress-related hormone cortisol has been studied in depression for decades. However, relatively little is known about the role of cortisol in psychological features of depression.
- Trial name
- DASH (NCT03195933)
- Testing
- Cortisol
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Anorexia Nervosa
Microbiome Shifts in Adolescent Anorexia Nervosa
The aim of this study is to evaluate the effect of starvation and recovery in adolescent anorexia nervosa patients in regard to microbiome activity and composition and to elucidate potential connections between weight gain…
- Trial name
- MaAN (NCT02962726)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Depression, Anxiety
Creatine for Depressed Male and Female Methamphetamine Users
Assess the antidepressant/anxiolytic effect of creatine in male and female methamphetamine users Assess creatine's effect on methamphetamine use Assess the safety of creatine in male methamphetamine users with depression
- Conditions
- Depression, Anxiety, Methamphetamine Dependence
- Trial name
- NCT02568878
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Montana State University
Tumor in Upper Gastrointestinal Canal or Patients With Colorectal Cancer
Observational Study of Early Contact With Palliative Care Unit for Patients Receiving First Line Palliative Chemotherapy With Cancer in Upper Gastrointestinal Canal, or Second Line Palliative Chemotherapy in Patients With Colorectal Cancer - an Open, Randomised Investigator Initiated Trial.
In this trial, patients with cancer in the upper gastrointestinal canal who are going to receive first line palliative chemotherapy and patients with colorectal cancer who are going to receive second line palliative chemotherapy…
- Trial name
- ALLAN (NCT02246725)
- Testing
- Contact with palliative care unit.
- Where
- Sweden
- Volunteers
- 108 people
- Sponsor
- Lund University Hospital
Late-life Depression, Major Depressive Disorder
Cognitive Behavioural Therapy for the Treatment of Late Life Depression
This study addresses the unmet medical problem of insufficient treatment of late life depression (LLD). Compared with depression in early adulthood, treatment options of LLD are limited.
- Conditions
- Late-life Depression, Major Depressive Disorder, Major Depressive Episode, Major Depressive Disorder, Recurrent
- Trial name
- CBTlate (NCT03735576)
- Testing
- Psychotherapy, Questionnaires, Magnetic Resonance Imaging
- Where
- 7 sites in Germany
- Volunteers
- 250 people
- Sponsor
- University of Cologne
Treatment Resistant Major Depression Disorder
DBS of the Habenula for Treatment- Resistant Major Depression
The habenula(Hb) is an epithalamic structure located at the center of the dorsal diencephalic conduction system, a pathway involved in linking forebrain to midbrain regions.
- Trial name
- NCT03347487
- Testing
- Deep brain stimuation system implantation
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Ruijin Hospital
Multiple Sclerosis, Depression
Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)
This project is a double-blind, sham-controlled, parallel-arm, randomized controlled trial. We will recruit n=170 people living with MS, who are experiencing an episode of depression in the context of a major depressive episode…
- Trial name
- NCT06901687
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- NYU Langone Health
Cancer in Remission (Any Type or Stage), Depression
Repetitive Transcranial Magnetic Stimulation in Cancer Patients With Depression and Anxiety
Cancer is a leading cause of mortality and morbidity worldwide. In addition, cancer is associated with high rates of depression and anxiety among its sufferers, and cancer patients with depression usually have worse treatment…
- Conditions
- Cancer in Remission (Any Type or Stage), Depression, Anxiety
- Trial name
- rTMSinCP (NCT01701284)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Mental Health Issue, Depression
Clinical Investigation of Syndi
Mental health concerns are a growing global concern, but support can still be difficult to access. Digital health technologies can help people access support, but with over 10,000 mental health apps available, it can be difficult…
- Conditions
- Mental Health Issue, Depression, Anxiety
- Trial name
- NCT06451549
- Testing
- Syndi recommender system for mental health apps
- Where
- 4 sites in United Kingdom
- Sponsor
- Newcastle University
Depression, Unipolar Depression
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression.
- Conditions
- Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CREST-MST (NCT03191058)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 239 people
- Sponsor
- University of Texas Southwestern Medical Center
Anxiety Disorder; Mixed With Depression (Mild)
Pilot RCT to Test Effectiveness of the ACE4 (Activity Challenge- 4 Areas) for Depression and Anxiety
Behavioral activation (BA) is a low cost, evidence-based intervention that can be effective in treating depression and anxiety. We have developed a behavioural activation card game for clients receiving treatment through the…
- Trial name
- NCT02538549
- Testing
- ACE4
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Queen's University
Depression
tDCS in the Prevention of Relapse After Electroconvulsive Therapy
While electroconvulsive therapy (ECT) in major depression is effective, high relapse rates and cognitive side effects limit its long-term use.
- Trial name
- NCT02886858
- Testing
- Device : Transcranial direct current stimulation
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Hôpital le Vinatier
MAjor Depressive Disorder
The Experience of Older Adults Facing Depression for the First Time in Old Age
Analysis of recent studies show that researchers find it hard to distinguish between Late Onset Depression, a first diagnosed major depressive episode which occurs at old age, and Early Onset Depression, a depressive episode at…
- Trial name
- NCT03009448
- Testing
- Interview
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Shalvata Mental Health Center
Affect, Wellness, Psychological
The Effects of Walking in Nature (vs. an Urban Setting) on the Wellbeing of Postsecondary Students.
The goal of this randomized controlled trial is to examine the effects of a walking intervention (3 walks per week for a period of 4 weeks) in a nature vs. urban setting on the wellbeing of young adult postsecondary students.
- Conditions
- Affect, Wellness, Psychological, Depressive Symptoms, Anxiety Disorders and Symptoms
- Trial name
- NCT05889078
- Testing
- A 4-week walking intervention
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- McGill University
Posttraumatic Stress Disorder, Depression
A Study of Sertraline to Prevent PTSD
The broad, long-term objectives of this proposal are to prevent the emergence of posttraumatic stress and depressive symptoms in children admitted for an acute burn, reconstructive surgery, or non-burn injury.
- Trial name
- NCT00182078
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Massachusetts General Hospital
Depression
Neural Mechanisms of Temporal Interference Stimulation on Improving Social Reward Function in Depression
Major depressive disorder (MDD) is a mood disorder characterized primarily by low mood, diminished interest, and reduced energy.
- Trial name
- NCT07287878
- Testing
- Temporal Interference Simulation(TIS), Temporal Interference Stimulation(TIS)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Depression
Efficacy of Narrative Therapy for Older People With Depression
The research aims to investigate the efficacy of a narrative therapy group in reducing depressive symptoms among older people. This study adopts a mixed methods research design, involving both quantitative and qualitative…
- Trial name
- NTOPD (NCT07371988)
- Testing
- Narrative therapy group, Treatment as usual (TAU)
- Where
- Hong Kong
- Volunteers
- 110 people
- Sponsor
- City University of Hong Kong
Treatment Resistant Depression, Treatment Resistant Depression (TRD)
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
Major depressive disorder (MDD) is a significant public health problem and leading cause of worldwide disability. Treatment resistance is common in MDD, however, for these individuals, targeted noninvasive brain stimulation is an…
- Trial name
- SPARC-TMS (NCT07227103)
- Testing
- Neuronavigated robotic-enabled TMS, NRX-101
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- NeuroRx, Inc.
Opioid Overdose
Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg
The purpose of this study is to determine the pharmacodynamics (change in minute ventilation) of nalmefene when given as an autoinjector intramuscularly (IM; into the thigh) compared to naloxone when given intranasally (IN; into…
- Trial name
- NCT06719986
- Testing
- Nalmefene HCl injection, Naloxone HCl intranasal
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP