Clinical trials: Deprescribing
Polypharmacy (People Under Treatment With 5 or More Drugs), Elderly (People Aged 65 or More)
Prevalence of Inappropriate Prescriptions and Omitted Therapies in Hospitalized Elderly: STOPP/START Criteria Analysis
Evaluate the prevalence of potentially inappropriate prescriptions (PIPs) and potential omitted prescriptions (PPOs) in elderly patient upon admission to the acute geriatric department, based on adherence or non-adherence to the…
- Conditions
- Polypharmacy (People Under Treatment With 5 or More Drugs), Elderly (People Aged 65 or More), Deprescribing, Hospitalization
- Trial name
- SPIna (NCT07202962)
- Testing
- medication review and deprescribing
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Regione del Veneto - AULSS n. 7 Pedemontana
Polypharmacy, Dementia
Shared Decision Making About Medication Use for People With Multiple Health Problems
The Shared Decision Making about Medication Use for People with Multiple Health Problems study will assess the feasibility and acceptability of a deprescribing educational intervention in primary care for patients with mild…
- Conditions
- Polypharmacy, Dementia, Multiple Chronic Conditions, Deprescribing
- Trial name
- NCT05156073
- Testing
- Educational Materials
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Benzodiazepine Use, Insomnia
Brief Cognitive Behavioral Therapy to Enhance Benzodiazepine Deprescribing
The goal of this clinical trial is to conduct a single-arm pilot trial of a brief cognitive-behavioral therapy-enhanced benzodiazepine deprescribing intervention in 20 older adults (aged ≥55 years) prescribed chronic…
- Conditions
- Benzodiazepine Use, Insomnia, Anxiety
- Trial name
- NCT06119308
- Testing
- Benzodiazepine Medication Taper with Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Beth Israel Deaconess Medical Center
Aging
MODIFY or Medication Review in Primary Care Study
A third of older people take five or more regular medications (polypharmacy) potentially increasing the risk of side-effects, hospital admission and death, with higher risk among people living with frailty.
- Trial name
- MODIFY (NCT05705284)
- Testing
- Structured multidisciplinary medication review
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Southampton
Major Neurocognitive Disorder
GPS Project Evaluation of the Impact of the Reorganization of Work Into a Family Medicine Group on Pharmacotherapy and Support for the Autonomy of Seniors With Major Neurocognitive Disorders
The model of care tested in the GPS project aims to optimize pharmacotherapy for seniors undergoing cognitive assessment or suffering from major neurocognitive disorder (MCND) at home.
- Trial name
- NCT04889794
- Testing
- GPS clinical intervention
- Where
- 2 sites in Canada
- Volunteers
- 400 people
- Sponsor
- CHU de Quebec-Universite Laval
Comorbidity, Multimorbidity
Interdisciplinary Medication Review Interventions in an Integrated Outpatient Department.
Inappropriate medication prescribing is highly prevalent among comorbid medical patients and leading to adverse drug events (ADE), re-admissions, quality of life and mortality.
- Conditions
- Comorbidity, Multimorbidity, Drug Prescribing, Cognitive Impairment
- Trial name
- FMA-CPH (NCT03912103)
- Testing
- Interdisciplinary Deprescribing and Medication Optimization Intervention
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Region Hovedstadens Apotek
Deprescribing
Leveraging Behavioral Science to Improve Medicine Optimization Conversations With Older Adults
Our online, survey-based experiment will include 2,400 adults who are 65-years and older (n=1,200 each from United States and Australia).
- Trial name
- NCT06698770
- Testing
- Anticipated long-term use of medication, Period re-evaluation of medication
- Where
- United States
- Volunteers
- 2,420 people, healthy volunteers welcome
- Sponsor
- University of Michigan