Clinical trials: Deprescribing
Polypharmacy, Inappropriate Prescribing
Randomised, Controlled Trial of an Individual Deprescribing Intervention for Nursing Homes Residents
This study will evaluate the effects of a pharmacist-led, deprescribing-focused medication review on the use of inappropriate medications by nursing home residents
- Trial name
- OLD-NH-IDeI (NCT03655405)
- Testing
- Individual Deprescribing Intervention
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- Anne Niquille
Polypharmacy, Deprescribing
Effect of Medication Management at Home Via Pharmacy Home Televisits
Older Veterans, particularly those with multiple chronic conditions requiring complex medication regimens, are more susceptible to adverse effects of medications.
- Conditions
- Polypharmacy, Deprescribing, Telemedicine
- Trial name
- NCT04340570
- Testing
- Medication management via televisit to home
- Where
- 2 sites in United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Polypharmacy, Frail Elderly Syndrome
Discontinuation of Long-term Medications in Older People Entering Nursing Home Care
Older people often have several chronic diseases requiring several medications all at once. Taking several medications all at once is called polypharmacy. Polypharmacy is common in nursing home residents.
- Conditions
- Polypharmacy, Frail Elderly Syndrome, Inappropriate Prescribing, Drug-Related Side Effects and Adverse Reactions
- Trial name
- STOPPFrail (NCT03501108)
- Testing
- STOPPFrail deprescribing criteria
- Where
- Ireland
- Volunteers
- 160 people
- Sponsor
- University College Cork
Polypharmacy (People Under Treatment With 5 or More Drugs), Polypharmacy, Decision-making
Factors Determining the Rate of Adoption of Pharmaceutical Recommendations by Patients in Primary Care Following a Medication Review by a Pharmacist
Polypharmacy is a growing public health concern associated with adverse drug events, drug interactions, and hospitalizations. Medication reviews (MedRev) are structured evaluations of patients' medications aiming to optimize…
- Conditions
- Polypharmacy (People Under Treatment With 5 or More Drugs), Polypharmacy, Decision-making, Medication Review
- Trial name
- REVMedAdopt (NCT07606716)
- Testing
- medication review and deprescribing
- Where
- Belgium
- Volunteers
- 123 people
- Sponsor
- Université Catholique de Louvain
Inappropriate Prescribing, Primary Health Care
Deprescribing in Primary Health Care
Medications can help older adults but can also harm them. Frail older adults tend to have many health problems that require treatment, but are also at risk of harm from the medications prescribed.
- Conditions
- Inappropriate Prescribing, Primary Health Care, Polypharmacy
- Trial name
- NCT03903484
- Testing
- Deprescribing toolbox and intervention
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Hypothyroidism
Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
The proposed study focuses on testing a novel adapted evidence-based multilevel intervention, Deprescribing Thyroid Hormone In Older Adults (D-THIO), to support thyroid hormone deprescribing (dose de-escalation and/or…
- Trial name
- NCT06629272
- Testing
- D-THIO (Deprescribing Thyroid Hormone In Older Adults), Enhanced usual care
- Where
- 3 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Overactive Bladder, Deprescribing
Deprescribing dRrugs for Overactive Bladder in General Practice (DROP)
The objective is to understand and evaluate the effectiveness of a deprescribing intervention in primary care, specifically targeting medications for overactive bladder in individuals aged 65 or older.
- Conditions
- Overactive Bladder, Deprescribing, PIMS
- Trial name
- DROP (NCT06110975)
- Testing
- deprescribing-intervention
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Anne Estrup Olesen
Hypertension, Frailty
Antihypertensive Deprescribing in Long-term Care
Frail older adults are commonly prescribed blood pressure medication, yet it is unclear if blood pressure medication is actually beneficial for them.
- Trial name
- OptimizeBP (NCT05047731)
- Testing
- Antihypertensive medication
- Where
- Canada
- Volunteers
- 522 people
- Sponsor
- University of Alberta
Medication Adverse Effects, Older Adults (65 Years and Older)
Population Health Approach to Optimizing Medications in Older Adults
This randomized controlled pragmatic pilot study examines the feasibility and acceptability of a population health-based deprescribing intervention that leverages a polypharmacy risk prediction model.
- Conditions
- Medication Adverse Effects, Older Adults (65 Years and Older), Polypharmacy, Polypharmacy Patients
- Trial name
- POP-MED (NCT06110156)
- Testing
- Patient-tailored deprescribing assessment and intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Anxiety, Insomnia
Augmenting Benzodiazepine Receptor Agonist Deprescribing With Acupuncture and Yoga Among Older Adults
The main purpose of this 12-week study is to see if a new combination of treatments can help older adults reduce benzodiazepine or related medication use.
- Conditions
- Anxiety, Insomnia, Benzodiazepine, Deprescription
- Trial name
- NCT06197243
- Testing
- Acupuncture, Yoga, Deprescribing
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Heart Failure, Heart Failure, Diastolic
Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF
In this study, we will test the feasibility of N-of-1 trials for deprescribing beta-blockers in patients with Heart Failure with Preserved Ejection Fraction.
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- NCT04757584
- Testing
- Beta blockers
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Weill Medical College of Cornell University
Medication Overuse, Deprescriptions
Prescribing Outcomes of a GP-Targeted Deprescribing Educational Intervention: A Cluster Randomized Trial
Polypharmacy is a common and growing public health concern across healthcare settings worldwide and is associated with an increased risk of inappropriate prescribing and adverse drug events.
- Conditions
- Medication Overuse, Deprescriptions, Polypharmacy, Frailty Syndrome
- Trial name
- NCT06470308
- Testing
- Medication Reviews and Deprescribing
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Crete
Benzodiazepine Deprescribing
Benzodiazepines Deprescribing in the Community Setting: Intervention Feasibility
The goal of this feasibility study is to evaluate the feasibility of an intervention, led by the pharmacist, aiming at benzodiazepines and z-drugs deprescribing in older adults living in the Belgian community setting.
- Trial name
- END-IT CS (NCT05929417)
- Testing
- END-IT intervention for the community setting
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Université Catholique de Louvain
Chronic Obstructive Pulmonary Disease (COPD)
Improving Medication Management in COPD
A pilot trial to examine feasibility of a pharmacist-led intervention for patients with COPD (Chronic Obstructive Pulmonary Disease) and multimorbidity to improve medication safety and reduce dyspnea.
- Trial name
- NCT07453719
- Testing
- Pharmacist-led Medication Management Intervention
- Volunteers
- 92 people
- Sponsor
- Duke University
Inappropriate Prescribing, Reflux Disease
Deprescribing Inappropriate Proton Pump Inhibitors
The DROPIT Trial is an interventional, open-labelled, cluster-randomized controlled trial conducted in the Swiss primary care setting.
- Conditions
- Inappropriate Prescribing, Reflux Disease, Proton Pump Inhibitors
- Trial name
- DROPIT (NCT06129474)
- Testing
- Proton Pump Inhibitor deprescribing tool
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Bern
Insomnia Chronic
Protocol - Your Answers When Needing Sleep in New Brunswick
New Brunswick has an aging population with Canada's highest rate of sleeping pill use. The rate of long-term (chronic) use among NB seniors is 25%, well in excess of the Canadian average of 10%.
- Trial name
- YAWNS NB (NCT04406103)
- Testing
- Sleepwell, Empower
- Where
- Canada
- Volunteers
- 594 people
- Sponsor
- David Gardner
Statin Treatment for Primary Prevention
STREAM Trial - Statins in Multimorbid Older Adults Without Cardiovascular Disease
Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older…
- Trial name
- STREAM (NCT05178420)
- Testing
- Statin discontinuation
- Where
- 24 sites in France, Netherlands and 1 more
- Volunteers
- 1,880 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Depression
WiserAD: The Effect of a Structured Online Intervention on Antidepressant Deprescribing in Primary Care
The use of antidepressants (ADs) is increasing globally, including within Australia, which has one of the highest rates of AD prescribing.
- Trial name
- WiserAD (NCT05355025)
- Testing
- WiserAD, Attention control
- Where
- Australia
- Volunteers
- 312 people
- Sponsor
- University of Melbourne
Mental Disorders, Severe
Transmural Collaborative Care Model for CVRM and Medication Review for Patients Using Antipsychotics
Currently, monitoring of usage and effects of antipsychotic treatment and cardiovascular risk screening in patients with severe mental illness or antipsychotic treatment is not sufficient.
- Trial name
- TACTIC (NCT05647980)
- Testing
- TACTIC
- Where
- Netherlands
- Volunteers
- 480 people
- Sponsor
- Radboud University Medical Center
Cancer
STATIC - Statin Termination in Cancer
There are many guidelines on when to start drug treatment, but surprisingly few guidelines on how and when to stop drugs. For example, there are currently no clear guidelines on when to stop preventive medications such as statins…
- Trial name
- STATIC (NCT07543432)
- Testing
- Deprescribing statins
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Stiftelsen Stockholms Sjukhem