Clinical trials: Deprescribing
Polypharmacy, Inappropriate Prescribing
SPIDER: A Research & QI Collaboration Supporting Practices in Improving Care for Complex Elderly Patients
Elders living with multiple chronic conditions often take many drugs (polypharmacy); some of the drugs may not benefit them or may be harmful.
- Conditions
- Polypharmacy, Inappropriate Prescribing, Aged, Primary Health Care
- Trial name
- SPIDER (NCT03689049)
- Testing
- SPIDER, Usual Care
- Where
- 9 sites in Canada
- Volunteers
- 104 people
- Sponsor
- University of Toronto Practice Based Research Network
Alzheimer Disease, Mild Cognitive Impairment
Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges
The objectives of this study are to demonstrate the feasibility of implementing a deprescribing nudge intervention using pragmatic methods, confirm that outcomes can be feasibly measured and evaluated at scale in a subsequent…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06347172
- Testing
- Nudge Intervention
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- Brigham and Women's Hospital
Sarcopenia
(De)Prescribing in Hospitalized Sarcopenic Geriatric Patients
The goal of this clinical trial is to compare the effects of a deprescribing pharmacotherapy approach to the STOPP-START approach (usual care) in geriatric patients with sarcopenia and polypharmacy.
- Trial name
- MEDEGESARC (NCT05757765)
- Testing
- deprescribing pharmacotherapy approach (DPA), STOPP-START deprescribing approach (SSA)
- Volunteers
- 160 people
- Sponsor
- Zuyderland Medisch Centrum
Palliative Care, Cancer
Attitudes Towards Deprescribing Medications in Cancer Patients and Impact of Educational Intervention by a Clinical Pharmacist
Participation in this study consists in responding to some questions from two questionnaires in Romanian about how participants feel about deprescribing, participants' treatment and how participants understand medical…
- Trial name
- NCT06771999
- Testing
- Educational intervention by a clinical pharmacist
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Polypharmacy
Feasibility Study of a Systematic Approach for Deprescribing of Statins and PPI's.
Deprescribing, the process of safely reducing or discontinuing unnecessary or harmful medication, has the potential to decrease polypharmacy and improve health outcomes.
- Trial name
- FeDeS+P (NCT04204590)
- Testing
- Deprescribing algorithm
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Zuyderland Medisch Centrum
Heartburn, Dyspepsia
Primary carE PPi dEprescRibing Trial
Proton pump inibitors (PPIs) is a class of medications that reduce the acid secretion in the stomach. These medications are very effective to relieve symptoms of acid reflux for a well-identified group of diseases and conditions.
- Conditions
- Heartburn, Dyspepsia, Reflux
- Trial name
- PEPPER (NCT05629143)
- Testing
- de-prescription of PPI via intermittent scheme, de-prescription of PPI via on-demand scheme, Alginate
- Where
- Belgium
- Volunteers
- 724 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Polypharmacy, Deprescriptions
Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal
This study protocol comprises three phases. The first two phases will be nationwide and aim to evaluate the prevalence and patterns of polypharmacy and assess the barriers and facilitators of deprescribing perceived by older…
- Trial name
- DePil17-20 (NCT03283735)
- Testing
- Elderly Enablement
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
Polypharmacy, Deprescribing
Spread and Scale of a Polypharmacy App
Medication overload is an epidemic causing widespread harm, particularly to older Canadians. While most prescriptions are intended to help people live longer and healthier lives, taking multiple medications can increase frailty…
- Conditions
- Polypharmacy, Deprescribing, Adverse Drug Event
- Trial name
- NCT04762303
- Testing
- MedReviewRx
- Where
- 5 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- Centre for Innovation and Research in Aging, Canada
Quality of Life, Reduction, Harm
Medication Use and Quality of Life Among Older People
This project will provide new evidence on how to optimize medication use among older people with limited life expectancy. This will be done by testing whether a patient-centered deprescribing intervention, focused on aligning…
- Trial name
- NCT05123313
- Testing
- Deprescribing intervention
- Where
- Denmark
- Volunteers
- 191 people
- Sponsor
- Odense University Hospital
Aging
Using Reinforcement Learning to Personalize Electronic Health Record Tools to Facilitate Deprescribing
The overall goal of the proposed research is to refine and adapt and perform efficacy testing of a novel reinforcement learning-based approach to personalizing EHR-based tools for PCPs on deprescribing of high-risk medications…
- Trial name
- REINFORCE-EHR (NCT06660979)
- Testing
- Reinforcement learning
- Where
- United States
- Volunteers
- 1,249 people
- Sponsor
- Brigham and Women's Hospital
Deprescribing, Antidepressant
General Practitioner & Pharmacist Support for Discontinuing Long-term Antidepressants in Clinically Stable Patients
In Belgium, many adults who have suffered from depression keep using antidepressants on a daily basis for years afterwards, sometimes longer than guidelines recommend.
- Conditions
- Deprescribing, Antidepressant, Depression Disorder, Discontinuation
- Trial name
- GPS-AD (NCT07398053)
- Testing
- GPS-AD intervention
- Volunteers
- 324 people
- Sponsor
- University Ghent
Benzodiazepine-Related Disorders
Informative Exhibition for Deprescribing Benzodiazepines
The goal of this trial is to determine if an interactive and informative exhibition in the waiting room of a Primary Care Clinic can reduce the use of benzodiazepines in adults.
- Trial name
- ESUB (NCT06467019)
- Testing
- Informative Session
- Where
- Spain
- Volunteers
- 6,410 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Chronic Disease
Deprescribing and Health-related Effects
In a primary care settled quality improvement project aiming to deprescribe medication through a medication review intervention, we investigated how the implemented medication changes affected health-related outcomes in real-life…
- Trial name
- NCT05721534
- Testing
- Medication review
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Anne Estrup Olesen
Rheumatic Diseases, Inflammatory Arthritis
The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions
The goal of this prospective observational quality improvement study is to determine if a physician tool, MedSafer, combined with educational brochures for patients, can help to reduce the use of 'potentially inappropriate…
- Conditions
- Rheumatic Diseases, Inflammatory Arthritis, Systemic Lupus Erthematosus (SLE), Vasculitis
- Trial name
- NCT07278609
- Testing
- MedSafer deprescribing opportunity reports, EMPOWER brochures
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Adverse Drug Event
Reducing Post-discharge Adverse Drug Events Amongst the Elderly: a Multi-centre Electronic Deprescribing Intervention
Reducing medications and associated side effects in older adults: an electronic hospital-based intervention
- Trial name
- NCT03272607
- Testing
- Deprescribing opportunities
- Where
- 7 sites in Canada
- Volunteers
- 6,582 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Aging, Hypertension
Blood Pressure Management in the Care Home Population
The UK care home population is projected to increase significantly over the coming decades. A high proportion of individuals in a care home have multiple long-term conditions and take large amounts of prescribed medication.
- Trial name
- BPITCH (NCT06337682)
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- University of Leeds
Polypharmacy, Medication Review
Less Is More: Optimized Pharmacotherapy With Improved coNtinuity of CarE in hospitaLized oLder peOple
The goal of this cluster randomized controlled trial is to compare transitional multidisciplinary pharmacotherapeutic care (TMPC) with usual care in patients aged 70 years or older with polypharmacy, admitted to the hospital via…
- Trial name
- LIMONCELLO (NCT05899114)
- Testing
- Transitional Multidisciplinary Pharmacotherapeutic Care
- Where
- 16 sites in Netherlands
- Volunteers
- 1,241 people
- Sponsor
- Radboud University Medical Center
Deprescribing
How do Older Adults and Caregivers Feel About Their Medications?
The aim of this study is to study patients' and caregivers' perspectives towards deprescribing using the Revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire.
- Trial name
- NCT03233971
- Testing
- rPATD Questionnaire
- Where
- Singapore
- Volunteers
- 1,057 people
- Sponsor
- Monash University
Polypharmacy, Alzheimer Disease and Related Dementias
Aligning Medications With What Matters Most
The Aligning Medications with What Matters Most (ALIGN) study will assess the feasibility and preliminary efficacy of a deprescribing intervention to reduce medication regimen complexity and treatment burden for people living…
- Trial name
- ALIGN (NCT04938648)
- Testing
- Pharmacist-led deprescribing intervention
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Polypharmacy, Deprescribing
MedSafer E-care: an Automated Deprescribing Solution (E-CARE Study)
The investigators will link MedSafer (a Canadian-made electronic tool) with a large multi-national electronic medical record (EMR), MED e-care, through an existing application programming interface (API) that provides clinicians…
- Conditions
- Polypharmacy, Deprescribing, Adverse Drug Event
- Trial name
- E-CARE (NCT04087109)
- Testing
- Electronic decision support for deprescribing (MedSafer tool)
- Where
- Canada
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre