Clinical trials: Dental Surgeries
Pain
Evaluation of the Efficacy of Novel Ibuprofen Acetaminophen Combination Formulations in the Treatment of Post-surgical Dental Pain
This study will determine the overall analgesic efficacy of three different fixed dose ibuprofen plus acetaminophen formulations compared to ibuprofen alone and to placebo.
- Trial name
- NCT01559259
- Testing
- Ibuprofen/acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- Pfizer
Dental Pain
Study of Diclofenac Capsules to Treat Dental Pain
The purpose of this study is to determine whether Diclofenac Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT00985439
- Testing
- Diclofenac Test (lower dose), Diclofenac Test (upper dose), Celecoxib 400 mg
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Post-surgical Dental Pain
Efficacy Of Pf-04531083 In Treating Post-Surgical Dental Pain
The purpose of this study is to evaluate the overall pain relief of a single dose of PF-04531083 against placebo following third molar extraction.
- Trial name
- NCT01512160
- Testing
- PF-04531083, Ibuprofen
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Pfizer
Postoperative Dental Pain
A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo
Researchers are looking for a better way to relieve pain in people, such as after dental surgery. Participants in this study, have had 3 or 4 third molars (cheek teeth) removed and subsequently have moderate to severe tooth pain.
- Trial name
- NCT05485805
- Testing
- Naproxen sodium and caffeine (BAY2880376), Naproxen sodium (Aleve), Caffeine
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Bayer
Jaw, Edentulous, Partially
Implant Retained Rehabilitation With Surgical and Prosthetic Digital Workflow
The aim of this study is to prospectively collect clinical data to confirm the safety and clinical performance of Neodent Titanium Base Abutment and Pro PEEK Abutment in daily dental practice setting, by means of a randomized…
- Trial name
- NCT04066309
- Testing
- Neodent GM Helix Implant, GM Customizable Healing Abutment, GM Pro PEEK Abutment
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Neodent
Pain
Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain
This study will compare the analgesic efficacy of a single-dose of a novel ibuprofen formulation to placebo and acetaminophen in the treatment of post-surgical dental pain following "wisdom" tooth (third molar) removal.
- Trial name
- NCT01216163
- Testing
- Novel Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Pfizer
Periodontal Diseases
Evaluation and Comparison of Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Mouth Rinse
Izun Pharmaceuticals has shown that PeriActive, an oral rinse containing extracts of Sambucus nigra, Echinacea purpurea, and Centella asiatica significantly reduced gingival inflammation in an experimental gingivitis model in a…
- Trial name
- NCT02987634
- Testing
- PeriActive
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Izun Pharma Ltd
Post-Operative Pain, Third Molar Extraction
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7.5 mg and 15 mg, intravenous morphine (IV) 7.5 mg, immediate release oral (PO) morphine 60 mg or placebo in…
- Trial name
- NCT00390312
- Testing
- Intranasal Morphine 15 mg, Immediate Release Oral Morphine 60 mg, Intravenous morphine
- Volunteers
- 225 people
- Sponsor
- Javelin Pharmaceuticals
Jaw, Edentulous
Evaluation of Treatment With Fixture Microthread™ in Patients Missing All Teeth in the Upper Jaw, When Using One-Stage Surgery
The primary objective of the study is to evaluate the long-term survival rate of implants and prostheses when treating totally edentulous upper jaws with Fixture MicroThread (Micro-Macro) using a one-stage surgical procedure.
- Trial name
- NCT00748397
- Testing
- Fixture MicroThread (Micro-Macro)
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 54 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Dental Pain
Single Dose Study of N1539 in the Treatment of Pain Secondary to Dental Impaction Surgery
To evaluate the safety and efficacy of single IV doses of N1539 after dental impaction surgery.
- Trial name
- NCT00945763
- Testing
- N1539, Motrin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Postoperative Pain
A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-190)(COMPLETED)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
- Trial name
- NCT00092339
- Testing
- MK0966, rofecoxib
- Volunteers
- 125 people
- Sponsor
- Merck Sharp & Dohme LLC
Oral Surgery, Tooth Extraction
Assessment of DAFILON® Suture Material in Oral Surgery (Mucosal Sutures)
In this non-interventional study (NIS) a polyamide non-absorbable suture (Dafilon) will be evaluated for oral surgery (mucosal closure after e.g. wisdom teeth extraction, implant surgery, etc.) in adult patients
- Conditions
- Oral Surgery, Tooth Extraction, Dental Implants
- Trial name
- MUCODA (NCT04390620)
- Testing
- Mucosal Closure
- Where
- 2 sites in Germany, Spain
- Volunteers
- 105 people
- Sponsor
- Aesculap AG
Jaw, Edentulous, Partially
Study to Evaluate Implant Survival Rate of Astra Tech Fixture ST in the Posterior Maxilla With One-stage Surgery and Early Loading
The purpose of this study is primarily to evaluate implant survival rate of Astra Tech Fixture ST placed in the posterior maxilla.
- Trial name
- NCT00748241
- Testing
- Astra Tech Fixture ST
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Dental Pain
Safety and Efficacy Study of NTC-510 to Treat Pain Following Dental Surgery of Third Molars
To evaluate the efficacy of a single dose NTC-510 or NTC-510A for dental pain following third molar extraction.
- Trial name
- NCT02161354
- Testing
- NTC-510 capsules, NTC-510A Capsules
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NanoSHIFT LLC
Partial Edentulism
Evaluation of Immediate Versus Delayed Loading of Dental Implants With a Modified Surface
The purpose of this study is to evaluate the performance of a new dental implant with a modified surface in different loading protocols.
- Trial name
- NCT00782171
- Testing
- SLActive dental implant
- Where
- 19 sites in United States, Austria and 7 more
- Volunteers
- 266 people
- Sponsor
- Institut Straumann AG
Pain
Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain
This study will compare the pain relieving effect of a single-dose of a novel ibuprofen formulation to placebo and two formulations of standard ibuprofen in the treatment of post-surgical dental pain following "wisdom" tooth…
- Trial name
- NCT01098747
- Testing
- Novel Ibuprofen, Standard Ibuprofen
- Volunteers
- 335 people
- Sponsor
- Pfizer
Wound Healing Disorder, Wounds and Injuries
Bone Bioactive Liquid Efficiency in Improving Dental Implant Osteointegration Oral Soft Tissue Hellingand Oral Surgery
The investigators implanted 264 Galaxy TS implants (with or without BBL) in 33 patients across both jaws. Implant stability and osseointegration were assessed using Initial Stability Quotient (ISQ) measurements, computed…
- Conditions
- Wound Healing Disorder, Wounds and Injuries, Wound Surgical
- Trial name
- BBLIS (NCT06371430)
- Testing
- Dental Implant insertion and tooth extraction
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Biointelligent Technology Systems SL
Post-surgical Oral Wounds, Oral Cavity Surgery
Evaluation of the Performance and Safety of a Linear Hyaluronic Acid-Based Medical Device in the Treatment of Surgical Wounds in the Oral Cavity.
The PR-DENT study is an interventional, single-center, controlled clinical investigation aimed at evaluating the clinical performance and safety of a Class III medical device based on linear hyaluronic acid for the treatment of…
- Conditions
- Post-surgical Oral Wounds, Oral Cavity Surgery, Wound Healing/Regeneration, Dental Extraction Sites
- Trial name
- PR-DENT (NCT07421934)
- Testing
- Intervention: Linear Hyaluronic Acid (Gumblast), Control: Standard Surgical Procedure
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- The Wave Innovation Group s.r.l.
Acute Pain
Analgesic Efficacy and Safety of ADL5859 in Subjects With Acute Dental Pain After Third Molar Extraction
The objective of this study is to evaluate the analgesic efficacy and safety of ADL5859 compared with placebo and an active control (ibuprofen) in subjects with acute dental pain after third molar extraction.
- Trial name
- NCT00993863
- Testing
- ADL5859 30 mg, ADL5859 100 mg, ADL5859 200 mg
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Pain
Study Evaluating the Efficacy of an Ibuprofen Effervescent Tablet in the Treatment of Post-Surgical Dental Pain
Evaluation of the efficacy and safety of a single dose of an ibuprofen effervescent tablet in the treatment of pain following third molar extraction in comparison to single doses of placebo, standard ibuprofen tablets, and…
- Trial name
- NCT00631111
- Testing
- effervescent ibuprofen tablets, effervescent Aspirin plus Vitamin C tablets, ibuprofen tablets
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer