Clinical trials: Dementia Severe
Agitation
Ketamine Versus Haloperidol for Severe Agitation Outside the Hospital
This research study is being done to find out if one of two drugs, ketamine or haloperidol, is better for treating agitation. Agitation is a state of extreme emotional disturbance where patients can become physically aggressive…
- Trial name
- NCT02103881
- Testing
- Ketamine, Haloperidol
- Sponsor
- Hennepin Healthcare Research Institute
Dementia, Nursing Home Resident
Video Feedback Intervention in Nursing Home Residents With Dementia and Severe Challenging Behavior.
The purpose of this study is to evaluate how, under what circumstances and for whom the video feedback intervention works for (the caregivers of) people with dementia and severe challenging behavior in a nursing home setting.
- Conditions
- Dementia, Nursing Home Resident, Challenging Behavior
- Trial name
- NCT05658666
- Testing
- Video feedback intervention (in Dutch: Video Interventie Ouderenzorg)
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Aggression, Self-Injurious Behavior
Treatment of Severe Destructive Behavior: FCT Versus Wait-List Control
Children with an intellectual disability often display severe destructive behavior (e.g., aggression, self-injury) that pose risks to themselves or others and represent barriers to community integration.
- Trial name
- NCT02483572
- Testing
- Functional Communication Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Nebraska
Major Depression, Alzheimer's Disease
Retinoic Acid Homeostasis in Neuropsychiatric Diseases
It is hypothesized, that local retinoic acid (RA) homeostasis is functionally involved in the pathophysiology of depression. In a cross-sectional (and partly longitudinal) analysis, serum RA status will be assessed in healthy…
- Conditions
- Major Depression, Alzheimer's Disease, Alcoholism, Schizophrenia
- Trial name
- RAHND (NCT02439099)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Moderate Dementia, Severe Dementia
Can Virtual Reality Reduce Depression and Agitation in Older Adults With Moderate to Severe Dementia?
Dementia is a term used to describe a collection of symptoms including memory loss, problems with reasoning and communication, and a reduction in a person's ability to carry out daily activities.
- Trial name
- NCT04347668
- Testing
- Virtual Reality, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 266 people
- Sponsor
- Western University, Canada
Neurodegenerative Diseases, Behavioral Symptoms
Impact of Harp Therapy on Behavioral Disorders in Nursing Home Residents With Neurodegenerative Disease (ARPE)
The ARPE study looked at whether weekly harp therapy sessions could reduce behavioral problems in older adults living in memory care units of a nursing home (EHPAD).
- Conditions
- Neurodegenerative Diseases, Behavioral Symptoms, Dementia, Agitation
- Trial name
- ARPE (NCT07748013)
- Testing
- Harp therapy (receptive music therapy)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- LNA SANTE
Dementia Moderate, Dementia Severe
Dronabinol for Agitation in Dementia Crossover Trial
The goal of this clinical trial is to study the effects of dronabinol in US Veterans with agitation related to moderate to severe dementia.
- Conditions
- Dementia Moderate, Dementia Severe, Agitation,Psychomotor, Behavioral Symptoms
- Trial name
- NCT05612711
- Testing
- Dronabinol
- Where
- United States
- Sponsor
- Ralph H. Johnson VA Medical Center
Major Neurocognitive Disorder, Physical Activity
An Individualized Exergame Training Solution for People With Major Neurocognitive Disorder: a Usability Study
The aim of this study is to investigate the usability of a newly designed and developed user-centered exergame in older adults with major neurocognitive disorder (dementia).
- Conditions
- Major Neurocognitive Disorder, Physical Activity, Dementia
- Trial name
- NCT04664920
- Testing
- exergame
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Davy Vancampfort
Systolic Blood Pressure, Blood Pressure
IMST for Dementia Risk Reduction
Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and…
- Conditions
- Systolic Blood Pressure, Blood Pressure, Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT07349706
- Testing
- Inspiratory Muscle Strength Training High-Resistance, Inspiratory Muscle Strength Training Low-Resistance
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Florida State University
Parkinson's Disease Dementia
Long-term Safety of Rivastigmine Capsule and Patch in Patients With Mild to Moderately-severe Dementia Associated With Parkinson's Disease (PDD)
The purpose of this study is to provide long-term safety data for rivastigmine capsule and transdermal patch treatments, in particular the effect of rivastigmine on worsening of the underlying motor symptoms of Parkinson's…
- Trial name
- NCT00623103
- Testing
- Rivastigmine capsule, Rivastigmine transdermal patch
- Where
- 127 sites in United States, Argentina and 11 more
- Volunteers
- 583 people
- Sponsor
- Novartis
Alzheimer Disease
Impact of Therapeutic Educational Programme on the Alzheimer's Disease Affected Patient's Quality of Life
Therapeutic education expands in Alzheimer's Disease management in France. Several studies revealed a positive impact on caregiver's burden and/or quality of life.
- Trial name
- THERAD (NCT01796314)
- Testing
- Therapeutic Educational Program
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Toulouse
Breast Cancer, Chronic Myeloproliferative Disorders
Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant
RATIONALE: Alemtuzumab and glucocorticoids, such as prednisone or methylprednisolone, may be an effective treatment for acute graft-versus-host disease caused by a donor stem cell transplant.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00410657
- Testing
- alemtuzumab, methylprednisolone, prednisone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Dementia, Dementia Alzheimers
Persons With Dementia and Their Extended Family Caregivers
Immediate family members shoulder the majority of care responsibilities for persons living with dementia. However, due to various societal changes, elder care responsibilities have expanded to extended family members, including…
- Conditions
- Dementia, Dementia Alzheimers, Neuro-Degenerative Disease, Dementia of Alzheimer Type
- Trial name
- CareEx (NCT04863859)
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Karen Roberto
Depression NOS, Major Depressive Disorder
Meditation to Reduce Caregiver Stress
The purpose of this study is to determine whether meditation will reduce stress and depressive of adult caregivers of a person with dementia.
- Conditions
- Depression NOS, Major Depressive Disorder, Anxiety NOS
- Trial name
- Meditation (NCT01537679)
- Testing
- Kirtan Kriya meditation, Relaxation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Psychomotor Agitation, Psychiatric Disorder
Randomised Trial Ketiapine Olanzapine Fast Sedation Agitated Patients Emergency Ward
comparison of intramuscular olanzapine and ketamine efficacy as first medication for fast sedation of patients with agitation and aggressive behavior.
- Conditions
- Psychomotor Agitation, Psychiatric Disorder, Emergency Psychiatric, Tranquilizers
- Trial name
- IM-OK-FAST (NCT03216941)
- Testing
- Ketamine
- Where
- Argentina
- Volunteers
- 500 people
- Sponsor
- Universidad Nacional de Rosario
Moderate to Severe Dementia
Pilot Study of a Robot-assisted Intervention for the Management of Care-induced Pain in Dementia
Health care professionals lack tools to deal with acute pain in patients with moderate to severe dementia during daily nursing situations.
- Trial name
- PARODOL (NCT03591822)
- Testing
- A : Systemic evaluation of the pain and mediation with the PARO therapeutic robot, B : Systemic evaluation of the pain
- Where
- 5 sites in France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer's Type Dementia
Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe Alzheimer's Disease
The purpose of this study is to compare 23 mg donepezil sustained release to the currently marketed formulation of 10 mg donepezil immediate release in patients with severe Alzheimer's disease.
- Trial name
- NCT01539031
- Testing
- E2020
- Where
- 54 sites in Japan
- Volunteers
- 351 people
- Sponsor
- Eisai Co., Ltd.
Mentalizing Imagery Therapy, Relaxation Recording
Meditation for Dementia Caregivers Major Depressive Disorder in Family Dementia Caregivers
Family dementia caregivers provide a needed service to relatives with dementia and to society, but are often at risk for consequences to their own health such as depression, reduced immune system function, and burnout.
- Trial name
- NCT02122068
- Testing
- Mentalizing Imagery Therapy, Relaxation cd
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, San Francisco
Severe Alzheimer Disease
A Study to Assess the Safety of GRF6019 Infusions in Subjects With Severe Alzheimer's Disease
This study will evaluate the safety, tolerability, and potential cognitive benefit of the experimental treatment GRF6019 in subjects with severe Alzheimer's disease.
- Trial name
- NCT03765762
- Testing
- GRF6019
- Where
- 6 sites in United States
- Volunteers
- 26 people
- Sponsor
- Alkahest, Inc.
Alzheimer Disease, Dementia With Lewy Bodies (DLB)
Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder
This is a retrospective observational study to evaluate the clinical utility of blood-based biomarkers in the diagnosis and management of patients with a neurodegenerative disease (ND) or mental disorder (MD).
- Conditions
- Alzheimer Disease, Dementia With Lewy Bodies (DLB), Frontotemporal Dementia (FTD), Major Depressive Disorder (MDD)
- Trial name
- Synapsing-BK (NCT07314190)
- Where
- Spain
- Volunteers
- 1,799 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau