Clinical trials: Dementia, open to volunteers
Alzheimer Disease (AD)
Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain
The goal of this clinical trial is to learn if tributyrin can help prevent or mitigate cognitive decline in individuals with mild Alzheimer's disease (AD).
- Trial name
- TRIM-GUT (NCT06797817)
- Testing
- tributyrin
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Universidad de Almeria
Dementia, Cognitive Function
B-vitamins and Omega-3 Fatty Acids and Biomarkers of Brain Atrophy.
A poor nutrition status is a modifiable risk factor for cognitive decline and dementia. In particular, evidence links low status of certain B-vitamins and ω-3 fatty acids (ω-3 FA) with a greater risk of cognitive decline and…
- Trial name
- BOOMERANG (NCT07312435)
- Testing
- Intervention, Control
- Where
- Norway
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Alzheimer Disease
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
The primary purpose of this study is to evaluate the safety and tolerability of Zunveyl® over 12 weeks of routine clinical use in adults with mild to moderate Alzheimer's disease.
- Trial name
- RESOLVE (NCT07633470)
- Testing
- Zunveyl®
- Where
- 22 sites in United States
- Volunteers
- 150 people
- Sponsor
- Alpha Cognition, Inc
PreDiabetes, Insulin Resistance
Disease Prevention in Clinical Practice Base on Patient Specific Physiology
It is well known that the Type 2 diabetes and vascular disease are preceded by over ten years by metabolic dysfunction and anatomic changes that can be quantified.
- Conditions
- PreDiabetes, Insulin Resistance, Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis
- Trial name
- STOPDISEASE (NCT03308773)
- Testing
- Lifestyle modification in routine care of patients
- Volunteers
- 5,000 people
- Sponsor
- Pacific Coast Family Medical Group
Alzheimer's Disease, Healthy Participants
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL921 in Healthy Participants and Participants With Alzheimer's Disease
This is a Phase 1/1b, multicenter, randomized, placebo-controlled, double-blind study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple doses of DNL921 in healthy…
- Trial name
- NCT07758595
- Testing
- DNL921
- Where
- United Kingdom
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Denali Therapeutics Inc.
Alzheimer's Disease
A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
Alzheimer's disease (AD) is a progressive, irreversible neurological disorder and is the most common cause of dementia in the elderly population.
- Trial name
- NCT07599670
- Testing
- ABBV-1758
- Where
- 13 sites in United States, China
- Volunteers
- 210 people
- Sponsor
- AbbVie
Amnesia, Alzheimer Disease
OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other…
- Conditions
- Amnesia, Alzheimer Disease, Lewy Body Disease, Parkinsons Disease With Dementia
- Trial name
- OCTAVO (NCT04389437)
- Testing
- Ophthalmological exam, Blood pressure measurement
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Autism, Intellectual Disability
Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability
In addition to the core symptoms, children and adolescents with Autism Spectrum Disorder (ASD) often exhibit disruptive behavior problems including irritability, tantrums, noncompliance, and aggression.
- Trial name
- NCT02914951
- Testing
- Cognitive-Behavioral Therapy, Functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Yale University
No Disease or Condition is Being Studied, Stress (Psychology)
Caring for Dementia Caregivers in Ethnic Immigrant Communities
Many caregivers of people with Alzheimer's disease or other dementias-especially those in immigrant communities who don't speak English well-don't get access to helpful, proven support programs.
- Trial name
- NCT07550075
- Testing
- K-Savvy, Healthy Living
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Dementia
Effectiveness of a Culturally Adapted Online Education Program (iSupport-Korea) for Family Caregivers of People With Dementia
This randomized controlled trial evaluates the effectiveness of iSupport-Korea, a culturally adapted online education program for family caregivers of people with dementia.
- Trial name
- NCT07609316
- Testing
- iSupport-Korea, Dementia information website
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Chungnam National University
Alzheimer's Disease, Biomarkers
Evaluation of a Plasma Marker (p-Tau217) for the Biological Diagnosis of Alzheimer's Disease, and Comparison With CSF Markers
The biological diagnosis of AD is actually performed by analysing Aβ1-40 and Aβ1-42 peptides, total tau and tau phosphorylated at Thr181 (p-Tau181) from cerebrospinal fluid (CSF) samples obtained by lumbar puncture (LP).
- Conditions
- Alzheimer's Disease, Biomarkers, Non-invasive Diagnosis, Phosphorylated Protein p-tau217
- Trial name
- ALZBIOSANG (NCT07071649)
- Testing
- blood withdrawal
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cognitive Dysfunction, Subjective Health
Effectiveness of TeleVR App in Cognitive Decline and MCI Patients
The goal of this clinical trial is to evaluate the effectiveness of a telerehabilitation program combined with a virtual reality (VR) app in improving cognitive performance and social skills in patients with Subjective Cognitive…
- Conditions
- Cognitive Dysfunction, Subjective Health, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- TeleVR24 (NCT06793735)
- Testing
- Telerehabilitation with Virtual Reality, Traditional Cognitive Rehabilitation
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Mild Cognitive Impairment (MCI)
AI-Supported Cognitive Rehabilitation for Older Adults With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is associated with increased risk of progression to dementia, highlighting the need for accessible interventions to support cognitive health.
- Trial name
- ReMind-AI (NCT07474038)
- Testing
- AI-Supported Cognitive Rehabilitation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Kaiser Permanente
Alzheimer Disease
Low-Intensity Focused Ultrasound (LIFU) Neuromodulation
This study is a prospective, single-center, single-arm early feasibility study, to establish safety and tolerability of LIFU for neuromodulation in patients with mild cognitive impairment ( MCI) due to Alzheimer's disease.
- Trial name
- NCT05997030
- Testing
- low intensity focused ultrasound (LIFU)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Ali Rezai
Dementia Caregiver, Depressive Symptoms
Telephone-coached "Graphic Narrative" Bibliotherapy for Dementia Caregivers
This study aims to assess the efficacy of telephone-coached graphic narrative bibliotherapy in improving dementia caregiver depressive symptoms compared with the booklet group.
- Conditions
- Dementia Caregiver, Depressive Symptoms, Caregiving Appraisal
- Trial name
- NCT06413849
- Testing
- Telephone coached graphic narrative bibliotherapy, Control group
- Where
- Hong Kong
- Volunteers
- 128 people
- Sponsor
- The Hong Kong Polytechnic University
Alzheimer Disease
PDE5 Inhibitor for Alzheimer's Disease
Alzheimer's disease is the most common cause of dementia in the elderly population. The disease is characterised by the presence of abnormal proteins in the brain, primarily β-amyloid (Aβ) and tau.
- Trial name
- NCT07172815
- Testing
- tadalafil
- Volunteers
- 244 people
- Sponsor
- Imperial College London
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico
Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06834893)
- Testing
- Cool roof
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Alzheimer Disease, End of Life
Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)
The palliative care education in assisted living for dementia care providers (PCEAL-DCP) is a 4-week intervention (once a week for 1.5 hours, a total of 6 hours) for licensed nurses, administrators and dementia care coordinators…
- Conditions
- Alzheimer Disease, End of Life, Caregiver Burden, Caregiver Burnout
- Trial name
- PCEAL-DCP (NCT06722352)
- Testing
- Palliative Care Training
- Where
- 2 sites in United States
- Volunteers
- 792 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Sleep, Alzheimer Disease
Sleep Trial to Prevent Alzheimer's Disease
The purpose of this study is to determine if treatment with the sleep aid suvorexant can decrease the rate of amyloid-β (Aβ) accumulation in the brain.
- Trial name
- SToP-AD (NCT04629547)
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Elder Mistreatment, Elder Abuse
Knowledge and Interpersonal Skills to Develop Enhanced Relationships (KINDER)
The Knowledge and Interpersonal Skills to Develop Enhanced Relationships (KINDER) intervention was developed to prevent psychological elder abuse (EA) and promote high-quality caregiving by lowering relationship strain and…
- Conditions
- Elder Mistreatment, Elder Abuse, Quality of Care, Dementia
- Trial name
- KINDER (NCT07216950)
- Testing
- Knowledge and Interpersonal Skills to Develop Enhanced Relationships, Healthy Living for the Caregiver
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University