Clinical trials: Dementia
Alzheimer Disease
Tricaprilin Phase 3 ALTER-AD (Alternative-Alzheimer Disease) Study
The purpose of this study is to evaluate the effects of tricaprilin (20 g twice a day) on cognition, global function, activities of daily living, resource utilisation, safety, and tolerability, in participants with mild to…
- Trial name
- ALTER-AD (NCT05809908)
- Testing
- Tricaprilin
- Volunteers
- 535 people
- Sponsor
- Cerecin
Music Listening
Impact of Individualized Music Listening for People With Dementia on Anxiety: A Quasi-experimental Study
This pilot study was designed to evaluate the effects of Individualized music listening (IML) implemented on older adults with mild cognitive impairment (MCI) and PwD.
- Trial name
- NCT06032897
- Testing
- Individualized music listening (IML)
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Alzheimer's Disease
Specific Care and Assistance Plan for Alzheimer's Disease
The main objective of this work is to assess the feasibility and efficacy of a specific Care and Assistance Plan for Alzheimer's disease (PLASA).
- Trial name
- PLASA (NCT00480220)
- Testing
- Global care and support program
- Where
- 40 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Toulouse
Ischemic Stroke, Hemorrhagic Stroke
Observational Study on Determinants of Dementia After Stroke
The primary aim of the DEDEMAS (Determinants of Dementia After Stroke) study is to identify predictors of post stroke dementia (PSD).
- Trial name
- DEDEMAS (NCT01334749)
- Where
- 5 sites in Germany
- Volunteers
- 736 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Polypharmacy, Alzheimer Disease and Related Dementias
Aligning Medications With What Matters Most
The Aligning Medications with What Matters Most (ALIGN) study will assess the feasibility and preliminary efficacy of a deprescribing intervention to reduce medication regimen complexity and treatment burden for people living…
- Trial name
- ALIGN (NCT04938648)
- Testing
- Pharmacist-led deprescribing intervention
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer Disease, Dementia
Cultural Adaptation of a Behavioral Intervention for Latino Caregivers
The overall objectives of the proposed research are to: (i) develop a prototype of a smartphone application (app) that can deliver culturally adapted STAR-C training to Latino caregivers, and (ii) understand the extent to which a…
- Trial name
- NCT04633408
- Testing
- STAR-C Virtual Training and Follow-up (STAR-VTF)
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alzheimer Disease, Down Syndrome
Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study
This study plans to establish a large bank of blood, cerebral spinal fluid (CSF), imaging, and clinical data. These data and samples will be used for future research into the causes of Alzheimer's disease (AD), Down Syndrome (DS)…
- Conditions
- Alzheimer Disease, Down Syndrome, Mild Cognitive Impairment
- Trial name
- NCT02612376
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Mild Dementia, Moderate Dementia
Touchscreen Technology and Art for People With Dementia in Care Homes
The prevalence of dementia is rapidly growing worldwide, affecting 46.8 million people in 2015. The 2014 Alzheimer's Society report estimated that 311,730 people with dementia were living in care homes in the United Kingdom (UK).
- Trial name
- NCT03773016
- Testing
- Art apps
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Alzheimer Disease
Single Dose Study of ALZ-801 Prototype Tablets
Phase 1, single-center, open-label, non-randomized, sequential single dose 4-period study in 12 healthy subjects to assess the pharmacokinetics of ALZ-801, tramiprosate and the primary metabolite of tramiprosate, NRM5074, from…
- Trial name
- NCT04585347
- Testing
- ALZ-801 170 mg Fasting, ALZ-801 205 mg Fasting, ALZ-801 205 mg After Food
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Alzheon Inc.
Dementia
Feasibility of a Dyadic Music-based Intervention for Persons Living With Dementia and Their Care Partners
This study examines the feasibility, acceptability, and preliminary outcomes of a structured music-based intervention for individuals living with dementia and their family care partners.
- Trial name
- NCT07843043
- Testing
- Dyadic Music-based Intervention (MBI), Reminiscence Activity
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Alzheimer Disease
Study of the Effect of SR57667B in Patients With Alzheimer's Disease
The primary objective is to demonstrate that SR57667B at the dose of 4 mg/day, in comparison to placebo, decreases the decline in cognitive performance and the global clinical decline over 1 year in patients with mild to moderate…
- Trial name
- NCT00285025
- Testing
- SR57667B
- Volunteers
- 500 people
- Sponsor
- Sanofi
Alzheimer's Disease and Related Dementias, Alzheimer Disease and Related Dementias
SmartEnLite for Nursing Home Residents With Dementia
The goal of this clinical trial is to learn if the Smart Environmental Lighting (SmartEnLite) can help improve behaviors and sleep among residents with dementia in nursing homes.
- Trial name
- SmartEnLite (NCT07883291)
- Testing
- Smart Environmental Light (SmartEnLite)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Penn State University
Insomnia
SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid
The objective of this study is to compare the efficacy of a sleep intervention on improving cognitive function in older adults with symptoms of insomnia, determine the association between change in sleep measures and change in…
- Trial name
- NCT03954210
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep and Lifestyle Education
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Alzheimer's Disease
Multi-modal Neuroimaging in Alzheimer's Disease IMAP+
Alzheimer's disease (AD) is a major public health problem due to its socio-economic weight. An early diagnosis of AD is urgently needed as it would constitute a determinant breakthrough from a social, financial and research…
- Trial name
- IMAP+ (NCT01638949)
- Testing
- Memory assessment, Circulating biomarkers measure, ApoE4
- Where
- 7 sites in France
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Delirium, Dementia
Speed of Processing Training for Cognitive Deficits After Delirium in Older Adults
In this proposal, we will examine processing speed training (PST) as a potential intervention to reduce the risk of developing long-term cognitive impairment after a delirium episode.
- Trial name
- NCT03342989
- Testing
- Speed of Processing Training, Internet-Based Contact Control
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Alabama at Birmingham
Cognitive Impairment, Dementia
Anticipating Decline and Providing Therapy
This pilot feasibility study will be a randomized control trial of usual care following Intensive Care Unit (ICU) discharge compared to the Anticipating Decline and Providing Therapy (ADAPT) screening and support intervention.
- Conditions
- Cognitive Impairment, Dementia, Post ICU Syndrome, Critical Illness
- Trial name
- ADAPT (NCT06182995)
- Testing
- Usual Care post-Intensive Care Unit (ICU), Anticipating Decline and Providing Therapy (ADAPT)
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Wake Forest University Health Sciences
Diabetes, Senile Dementia, Alzheimer Type
A Study of Mobile Medical Supportive Care Program for Family Caregivers With Dementia Combined With Diabetes
The purpose of this project is to evaluate the effectiveness of the clinical application of a mHealth supportive care program for family caregivers with dementia combined with diabetes based on the supportive care framework.
- Trial name
- NCT06785857
- Testing
- mHealth Supportive Care Program, Offline supportive care
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuanjiao Yan
Apathy, Behavior
Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated.
The purpose of this study is to provide relevant quantitative evaluation of apathy close to real life situation by means of a multimodal sensor system integrated.
- Conditions
- Apathy, Behavior, Frontotemporal Dementia
- Trial name
- ECOCAPTURE (NCT02496312)
- Testing
- Evaluation of Apathy Close to Real Life Situation
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alzheimer Disease, Early Onset
Novel Dementia Biomarkers
The study will investigate structural and functional characteristics of the brain of dementia patients compared to healthy controls in order to get a better insight into importance of early biomarkers for the diagnosis of…
- Trial name
- NCT04427436
- Testing
- No Intervention
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Dementia
Biomarker-Integrated Digital Guidance for Early Alzheimer's Detection (BRIDGE-AD): A Nationwide Multicenter Study
The investigators propose a stepwise screening approach. The first step involves rapid digital pre-screening of cognitive function through three components: the SCD-9 questionnaire to capture subjective cognitive complaints, a…
- Trial name
- NCT07284264
- Where
- 6 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing