Clinical trials: Delirium Prevention
Emergence Agitation, Postoperative Pain
Caudal Versus Intravenous Magnesium Sulfate on Emergence Agitation After Sevoflurane In Children.
Sevoflurane is the agent of choice for induction and maintenance of day care anesthesia in children and has a wide acceptance among pediatric anesthesiologists.
- Trial name
- NCT03846284
- Testing
- Bupivacaine, Magnesium sulfate 50mg, Magnesium sulfate 30 mg
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Mansoura University
Delirium
Prevention of Delirium With Light in the Intensive Care Unit
The purpose of this multicenter randomised controlled trial is to investigate if circadian light at the patients bedside (using Philips HealWell system, CE marked)significantly reduces prevalence of delirium in mechanically…
- Trial name
- PreDeLight-ICU (NCT01727375)
- Testing
- Circadian light
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Delirium
Melatonin for Prevention of Post- Operative Delirium Pilot Study Protocol
To test the efficacy of melatonin compared to placebo in preventing post-operative delirium and reduction in intensity or duration of delirium in individuals 65 years of age and older who undergo orthopedic surgery after low…
- Trial name
- NCT02903901
- Testing
- Melatonin
- Where
- United States
- Sponsor
- Loyola University
Sleep Disturbance, Delirium
Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients
Sleep disturbance is very common among critically ill patients in the intensive care unit (ICU), particularly in older adults after surgery.
- Conditions
- Sleep Disturbance, Delirium, Critical Illness
- Trial name
- NCT07407400
- Testing
- Lemborexant
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University
Delirium, Pain
Pregabalin in the Prevention of Postoperative Delirium and Pain
The purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves…
- Trial name
- NCT00819988
- Testing
- Pregabalin, Sugar pill
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Ottawa Hospital Research Institute
Postoperative Delirium
Impact of a Multifaceted Program to Prevent Postoperative Delirium in the Elderly
Postoperative delirium is common in the elderly and is associated with a significant increase in mortality, complications, length of hospital stay and admission in long care facility.
- Trial name
- CONFUCIUS (NCT01316965)
- Testing
- Multifaceted prevention program HELP(Hospital Elder Life Program)
- Where
- France
- Volunteers
- 175 people
- Sponsor
- Hospices Civils de Lyon
Postoperative Delirium
Clinical Trial With Quetiapine Prophylaxis Postoperative Delirium in High Risk Surgical Patients
Double blinded Clinical trial to test efficacy of Quetiapine versus placebo in reducing postoperative delirium in high risk surgical patients after three days of treatment.
- Trial name
- NCT03739476
- Testing
- Quetiapine 25 milligrams capsule
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Chronic Rhinosinusitis (CRS), Emergence Agitation
Trans-nasal Sphenopalatine Ganglion Block for Prevention of Emergence Agitation Following Functional Endoscopic Sinus Surgery
This randomized double-blind controlled trial aims to evaluate whether bilateral trans-nasal sphenopalatine ganglion block (SPGB) using bupivacaine reduces the incidence of emergence agitation following Functional Endoscopic…
- Trial name
- SPGB-EA (NCT07645521)
- Testing
- Bilateral Trans-nasal Sphenopalatine Ganglion Block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Delirium, Cognitive Decline
Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery
A parallel-group treatment, five-centre, participant and investigator masked, three-arm study to assess the safety and effectiveness of dexmedetomidine or clonidine infusion compared to placebo for the prevention of delirium and…
- Conditions
- Delirium, Cognitive Decline, Frailty
- Trial name
- ALPHA2PREVENT (NCT05029050)
- Testing
- Dexmedetomidine, Clonidine, Natriumchlorid
- Where
- 5 sites in Norway
- Volunteers
- 900 people
- Sponsor
- Oslo University Hospital
Delirium
Evaluation of Delirium Prevention in Critically Ill Patients
Haloperidol is prescribed in high risk ICU patients concerning delirium (50% or more chance to develop delirium detected with the delirium prediction model PRE-DELIRIC, or patients with history of dementia or alcohol abuse)since…
- Trial name
- NCT01187667
- Where
- Netherlands
- Volunteers
- 650 people
- Sponsor
- Radboud University Medical Center
Pseudomyxoma Peritonei, Postoperative Delirium (POD)
Proactive Temperature Management in CRS-HIPEC for Prevention of Delirium
This randomized controlled trial evaluates the efficacy of a proactive Goal-Directed Temperature Management (GDTM) protocol in reducing postoperative delirium among patients undergoing Cytoreductive Surgery (CRS) with…
- Trial name
- NCT07378371
- Testing
- Proactive Goal-Directed Temperature Management, Standard Reactive Temperature Management
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Aerospace Center Hospital
Delirium
Prophylactic Quetiapine on Delirium Prevention in Critically Ill Patients
The purpose of this study is to evaluate the efficacy of low dose quetiapine for the prophylaxis of delirium in critically ill patients in medical intensive care unit.
- Trial name
- NCT02297763
- Testing
- quetiapine
- Volunteers
- 194 people
- Sponsor
- Seoul National University Hospital
Delirium in Old Age, Delirium Superimposed on Dementia
Early Fall Risk Detection and Fall Prevention Among Inpatients With Delirium
During delirium patients are at risk of severe harm due to unattended bed-exits resulting in falls. This research intends to explore how effective alarming contact mats (CareMat®) in comparison to contactless bed-exit alarming…
- Conditions
- Delirium in Old Age, Delirium Superimposed on Dementia, Fall, Bed Falls
- Trial name
- QumPreFall (NCT05391334)
- Testing
- Qumea
- Where
- Switzerland
- Volunteers
- 170 people
- Sponsor
- University Department of Geriatric Medicine FELIX PLATTER
Delirium in Old Age, Delirium
PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients
Our objective is to find an effective prophylactic intervention by evaluating IV acetaminophen's impact in reducing the frequency of postoperative delirium, one of the most common and detrimental complications of cardiac surgery…
- Conditions
- Delirium in Old Age, Delirium, Coronary Artery Disease
- Trial name
- PANDORA (NCT04093219)
- Testing
- IV acetaminophen
- Where
- 10 sites in United States
- Volunteers
- 901 people
- Sponsor
- Beth Israel Deaconess Medical Center
Dexmedetomidine, Melatonin
Dexmedetomidine Infusion Versus Oral Melatonin for Prevention of Intensive Care Delirium
This study aims to compare the effect of dexmedetomidine infusion and oral melatonin on preventing delirium in intensive care unit (ICU) patients.
- Conditions
- Dexmedetomidine, Melatonin, Delirium
- Trial name
- NCT06076668
- Testing
- Dexmedetomidine, Melatonin 3 MG, Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Delirium, Intensive Care Unit Delirium
Partnering With Family Members to Prevent, Detect and Manage Delirium in Critically Ill Patients.
Almost half of critically ill patients experience delirium. Delirium is associated with impaired cognition, mortality, and increased healthcare costs.
- Conditions
- Delirium, Intensive Care Unit Delirium, Post Intensive Care Unit Syndrome, Post Intensive Care Unit Syndrome Family
- Trial name
- NCT04099472
- Testing
- Delirium Education, Prevention, and Management, Standard Care
- Where
- 4 sites in Canada
- Volunteers
- 128 people
- Sponsor
- University of Calgary
Delirium, Postoperative Cognitive Dysfunction
Prevention of Early Postoperative Decline
The purpose of this trial is to determine whether using a brain training program in the time leading up to as well as after heart surgery will reduce confusion and cognitive loss that can occur after surgery.
- Trial name
- PEaPoD (NCT02908464)
- Testing
- Lumosity
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Beth Israel Deaconess Medical Center
Delirium
Haloperidol Prophylaxis in Older Emergency Department Patients
The investigators propose a multicenter, randomized, double-blinded, placebo-controlled trial to study the effect of additive low-dose haloperidol prophylaxis on top of exciting care in a general population of older patients (age…
- Trial name
- HARPOON (NCT01530308)
- Testing
- Haloperidol
- Where
- 6 sites in Netherlands
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
ICU Delirium
Virtual Reality for ICU Delirium Prevention
The purpose of this study is to evaluate whether daily exposure to immersive virtual reality (VR) can reduce the incidence of delirium in high-risk, non-intubated ICU patients.
- Trial name
- NCT07357389
- Testing
- Virtual Reality therapeutics
- Where
- United States
- Volunteers
- 822 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Delirium
40 Hz Gamma Auditory Stimulation for Delirium Prevention in Critically Ill ICU Patients
Delirium is a common acute disturbance of attention and cognition among critically ill patients and is associated with prolonged mechanical ventilation, longer hospital stays, and increased mortality.
- Trial name
- NCT07875374
- Testing
- 40 Hz Gamma Auditory Stimulation, Silent Audio Control
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Peking Union Medical College Hospital