Clinical trials: Delayed Emergence From Anesthesia
Neuromuscular Block, Residual, Pain
Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults
This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective septoplasty or rhinoplasty.
- Conditions
- Neuromuscular Block, Residual, Pain, Postoperative Nausea
- Trial name
- NCT07187037
- Testing
- Methylprednisolone (MP), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Obesity, Neostigmine
Observational Study in Bariatric Surgery
Obesity in the world represents a growing share of the general population. At hospital, the management of these patients could be problematic especially when calculating the drug dosage.
- Conditions
- Obesity, Neostigmine, Residual Neuromuscular Blockade
- Trial name
- NEOCURE (NCT04244266)
- Testing
- NO INTERVENTION, it is an observational study
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Neuromuscular Blockade, Neuromuscular Blockade, Residual
Three Different Doses of Neostigmine on the Reversal of Cisatracurium-induced Moderate Neuromuscular Blockade
The aim of the present study will be to evaluate by means of a prospective randomized clinical trial, the time required for the reversal of moderate neuromuscular blockade (NMB) (Train-of-four count = 3; TOFc 3) to Train-of-four…
- Trial name
- NCT05037006
- Testing
- Sevoflurane - Neostigmine 30, Sevoflurane - Neostigmine 50, Sevoflurane - Neostigmine 70
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Neuromuscular Blockade, Residual
Neostigmine/Glyco-pyrrolate 50 Mikrogram/kg or Sugammadex 2 mg/kg for Reversal of Neuromuscular Blockade in Elderly Patients
The aim of this study is to determine the time to TOF ≥ 0.9 after either neostigmine/glycopyrrolate 50 mikrogr/kg or sugammadex 2 mg/kg in patients with age ≥ 75 years.
- Trial name
- NCT06228092
- Testing
- neostigmine/glycopyrrolate, Sugammadex
- Where
- 3 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Matias Vested
Delayed Emergence From Anesthesia, Delirium, Cause Unknown
Inadequate Emergence After Laparoscopic Surgery in Trendelemburg Position
The purpose of this study is to determinate if the patients submitted to laparoscopic surgery in trendelemburg position develope more inadequate anaesthesic emergence than patients submitted to laparoscopic surgery in other…
- Conditions
- Delayed Emergence From Anesthesia, Delirium, Cause Unknown, Confusion, Disorientation on Emergence
- Trial name
- NCT02101671
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Corporacion Parc Tauli
Postoperative Residual Curarization, Geriatrics
Postoperative Residual Curarization in Elderly Patients in Post-anesthesia Care Unit
In this study, we aimed to determine the knowledge levels and approaches of anesthesiologists working in our clinic about postoperative residual curarization(PORC) in elderly patients with a questionnaire.
- Trial name
- NCT05051371
- Testing
- Train of four monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara City Hospital Bilkent
Delayed Recovery From Anesthesia
Automated Control of End-tidal Volatile Anesthetic Concentration
The new MIRUS system as well as the established AnaConDa system uses a reflector to conserve volatile anaesthetics (VA). Both systems act with commercially available ICU ventilators.
- Trial name
- MIRCONTROL (NCT02342509)
- Testing
- Desflurane, Sevoflurane, Isoflurane
- Volunteers
- 63 people
- Sponsor
- Ruhr University of Bochum
Postoperative Complications, Delayed Emergence From Anesthesia
EEG-based Depth of Anesthesia-monitoring, Effects on Dosage and Cognition
Depth of anesthesia-monitoring based on EEG changes demands knowledge about the effects of the different anesthetic medications on EEG waveforms.
- Conditions
- Postoperative Complications, Delayed Emergence From Anesthesia, Cognitive Dysfunction
- Trial name
- NCT04529304
- Testing
- Bilateral Bispectral Index and EEG
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Postoperative Residual Curarization
Incidence of Postoperative Residual Neuromuscular Blockade in the Era of Sugammadex
This study is a prospective observational study. A total 52 patients will be included in this study. We will observe the incidence of postoperative residual neuromuscular blockade in patients receiving sugammadex.
- Trial name
- NCT05760560
- Testing
- Sugammadex
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Seoul National University Hospital
Kidney Transplant; Complications, Postoperative Residual Curarization
Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade at the End of Kidney Transplantation Surgery
The purpose of this study is to compare two medications that reverse muscle paralysis at the end of kidney transplant surgery with the goal of reducing residual muscle weakness and insufficient respiratory function after surgery.
- Conditions
- Kidney Transplant; Complications, Postoperative Residual Curarization, Postoperative Residual Weakness
- Trial name
- NCT03923556
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Colorado, Denver
Neuromuscular Blockade
Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor
A quantitative neuromuscular monitoring device is desirable to titrate the depth of neuromuscular block (NMB) during a procedure, and to prevent residual effects after removal of the endotracheal tube.
- Trial name
- NCT05632107
- Testing
- TOF-Watch®；DELSYS® Wireless surface EMG
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Huazhong University of Science and Technology
Anesthesia Recovery, Anesthesia Emergence
Intravenous Dexmedetomidine For The Quaity Of Emergence From General Anesthesia
In a prospective randomized clinical trial involving adult patients undergoing elective surgery under general anesthesia, the investigators will enroll 216 patients, and evaluate 3 doses of prophylactic dexmedetomidine as a means…
- Conditions
- Anesthesia Recovery, Anesthesia Emergence, Shivering, Postoperative Recovery
- Trial name
- NCT02141412
- Testing
- dexmedetomidine 0.25 µg/kg IV, dexmedetomidine 0.5 µg/kg IV, dexmedetomidine 1 µg/kg IV
- Where
- Lebanon
- Volunteers
- 216 people
- Sponsor
- American University of Beirut Medical Center
Residual Neuromuscular Blockade, Curarization, Postoperative Residual
Validation of the REPS Prediction Tool
Neuromuscular blocking agents' (NMBA) use during surgery is associated with postoperative respiratory complications and increased risk of readmission to the hospital following ambulatory surgery.
- Conditions
- Residual Neuromuscular Blockade, Curarization, Postoperative Residual, Postoperative Respiratory Complication
- Trial name
- NCT03585400
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 101,510 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Curarization, Postoperative Residual, Postoperative Pain Of Laparoscopic Surgery
Role of Curarization During Anesthesia for Laparoscopic Hysterectomy
The primary outcome of this study is to investigate whether deep NMB reversed with Sugammadex is superior to moderate NMB reversed with Neostigmine, in terms of overall pain in the first 48 hrs after laparoscopic hysterectomy…
- Conditions
- Curarization, Postoperative Residual, Postoperative Pain Of Laparoscopic Surgery, PONV
- Trial name
- NCT03519633
- Testing
- Sugammadex, Neostigmine
- Where
- Italy
- Volunteers
- 238 people
- Sponsor
- Campus Bio-Medico University
Postoperative Residual Curarization, Liver Transplantation
Sugammadex/Neostigmine and Liver Transplantation
Cirrhotic patients undergoing liver transplantation are at very high risk of post operative complication such as post-operative residual curarization.
- Trial name
- NCT02697929
- Testing
- sugammadex, Neostigmine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Delayed Emergence From Anesthesia
Can Caudal Dexmedetomidine Prevents Sevoflurane Induced Emergence Agitation in Children
Emergence agitation (EA) is common phenomenon in pediatric patients undergoing general anesthesia by inhalation agents. The incidence of EA was reported to range from 18% to 80%.
- Trial name
- NCT02757495
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Suez Canal University
Neuromuscular Blockade, Residual Curarisation, Postoperative
Provider Variability in the Use of Neuromuscular Blocking Drugs and Reversal
The use of neuromuscular blocking agents during surgery is associated with postoperative respiratory complications and increased risk of readmission to the hospital following ambulatory surgery.
- Conditions
- Neuromuscular Blockade, Residual Curarisation, Postoperative, Surgery Under General Anaesthesia
- Trial name
- NCT03585348
- Testing
- Neuromuscular blocking agents
- Where
- 2 sites in United States
- Volunteers
- 265,537 people
- Sponsor
- Beth Israel Deaconess Medical Center