Clinical trials: Delayed Emergence From Anesthesia
Neuromuscular Blockade, Anesthesia
Sugammadex Dosing: Anaesthesiologist Clinical Perception Versus Quantitative Monitoring
Many clinicians continue to rely on subjective evaluation in making decisions about the adequacy of neuromuscular function before tracheal extubation rather than using quantitative monitoring.
- Conditions
- Neuromuscular Blockade, Anesthesia, TOF, Curarization, Postoperative Residual
- Trial name
- NCT04762420
- Testing
- Dose of sugammadex according to SSD and QSD
- Where
- Portugal
- Volunteers
- 66 people
- Sponsor
- Hospital do Divino Espírito Santo de Ponta Delgada
Anesthesia, Neuromuscular Blockade
International Focus Group Discussion on Neuromuscular Monitoring.
Focus-Group based discussion designed to gain more in-depth information on factors that could lead to an increase in the adoption of neuromuscular monitoring taking into account different country-specific contexts.
- Conditions
- Anesthesia, Neuromuscular Blockade, Neuromuscular Block, Residual, Perioperative/Postoperative Complications
- Trial name
- NCT06945341
- Testing
- Focus-Group discussion
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Residual Neuromuscular Blockade
Effect of Calcium Chloride on Recovery From Neuromuscular Blockade
The purpose of this study is to evaluate the effect of calcium chloride against residual neuromuscular blockade at the end of general anesthesia
- Trial name
- NCT02213848
- Testing
- Calcium, control
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Residual Neuromuscular Blockade
Thumb vs Great Toe Recovery
Researches are comparing the accuracy of measuring muscle relaxation in the thumb versus the great toe.
- Trial name
- NCT04312256
- Testing
- TetraGraph
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Mayo Clinic
Residual Paralysis, Post Anesthesia
Best Management of Muscle Relaxation- Objective Monitoring
The purpose of this study is to demonstrate that the investigators can reduce residual paralysis to a very low incidence, and that the investigators can do this while preserving a role for the older and less expensive reversal…
- Trial name
- NCT03958201
- Testing
- Protocol for Management of Muscle Relaxation With Rocuronium Using Objective Monitoring and Reversal With Neostigmine or Sugammadex
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Washington
Neuromuscular Blockade, Sugammadex
Residual Paralysis and Reversal With Routine Neostigmine Versus Half-dose Sugammadex and Routine Neostigmine
Sugammadex may prevent residual neuromuscular blockade by providing rapid reversal at the end of the operation. Our goal is to compare the half-dose use of sugammadex for reversing residual blockade after administration of…
- Conditions
- Neuromuscular Blockade, Sugammadex, Neostigmine, Complication of Anesthesia
- Trial name
- NCT05066035
- Testing
- Neostigmine, Sugammadex
- Volunteers
- 113 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Awakening, Post-Anesthesia Delayed
Ketamine Versus Magnesium Sulfate in the Time and Awakening Quality of General Anesthesia.
The introduction of the laparoscopic technique for cholecystectomy significantly reduced the incidence and intensity of postoperative pain, with improvement in other markers, such as patient satisfaction, and reduction in…
- Trial name
- NCT04360473
- Testing
- General anesthesia, Ketamine plus general anesthesia, Magnesium sulfate plus general anesthesia
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo General Hospital
Neuromuscular Blockade, Residual
Incidence of Postoperative Residual Curarization
An incomplete postoperative recovery of neuromuscular function (postoperative residual curarization - PORC) represents a common problem in post-anesthesia care units (PACU), potentially exposing the patient to adverse respiratory…
- Trial name
- PORC (NCT06193213)
- Testing
- measurement of train of four ratio (TOFR) to assess residual neuromuscolar block
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Residual Neuromuscular Block
Neostigmine Reversal And Neuromuscular Recovery
Patients undergoing surgery often receive paralytic agents (or neuromuscular blocking agents (NMBAs)) to facilitate the procedure. At the end of surgery, the effects NMBAs are reversed with a drug called neostigmine.
- Trial name
- NCT02433808
- Testing
- Neostigmine Group, No Neostigmine group
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Residual Neuromuscular Blockade
Residual Neuromuscular Blockade in Pediatric Anesthesia
Residual neuromuscular blockade (RNB) is frequent and it is associated with postoperative morbidity and mortality. The incidence of the RNB in pediatric anesthesia is currently not known.
- Trial name
- REPEB (NCT02939911)
- Testing
- Residual neuromuscular blockade measurement
- Where
- Czechia
- Volunteers
- 291 people
- Sponsor
- Brno University Hospital
Residual Neuromuscular Blockade
Cardiac Output and Recovery Time
The purpose of this research is to determine the time it takes to reverse the effects of the intraoperative medication given to relax the muscles and how this period of recovery correlates with a function of the heart.
- Trial name
- NCT04619225
- Testing
- TetraGraph
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Neuromuscular Block, Residual
Diaphragm Function After Reversal of Rocuronium-induced Neuromuscular Blockade With Sugammadex or Neostigmine in Children
This study is to evaluate the recovery of diaphragm function and atelectasis after reversal of neuromuscular blockade with Neostigmine and Sugammadex using lung ultrasound and diaphragm ultrasound for children aged 2 to 7 who are…
- Trial name
- NCT05724550
- Testing
- Sugammadex, Neostigmine
- Where
- South Korea
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis
The use of intravenous muscle relaxants during anaesthesia can significantly facilitate endotracheal intubation and reduce the chance of possible airway complications during intubation.
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
- Trial name
- NCT07080528
- Testing
- Sevofluorane, Propofol
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Tamas Vegh, MD
Residual Neuromuscular Block (TOF-ratio of 0.2)
Sugammadex and Neostigmine at Residual Neuromuscular Blockade
This study is designed to compare recovery times after reversal of a residual neuromuscular block (TOF-ratio 0.2) with different doses of either neostigmine or sugammadex.
- Trial name
- SUNDRO20 (NCT01006720)
- Testing
- Sugammadex, Neostigmine, Saline
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Technical University of Munich
Neuromuscular Block, Residual
Evaluation of Residual Neuromuscular Blockade and of Late Recurarization in the Post Anesthesia Care Unit in Patients Undergoing Videolaparoscopic Cholecystectomy
Neuromuscular blockade is essential to provide optimal conditions for tracheal intubation and also to facilitate the performance of surgeries involving mainly the abdominal cavity.
- Trial name
- NCT03831815
- Testing
- Cisatracurium
- Where
- Brazil
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Residual Neuromuscular Block
Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function
Residual neuromuscular blockade (NMB) after general anesthesia increases the risk of postoperative respiratory complications (atelectasis, pneumonia, re-intubation) and delays pulmonary function recovery.
- Trial name
- NCT07309393
- Testing
- Sugammadex, Neostigmine
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Neuromuscular Block, Residual
Quantitative Versus qUAlitative NeuromoniToring of neUroMuscular Block for Non-cardiothoracic Surgery
The purpose of this study is to assess the effect of quantitative block monitoring versus less expensive qualitative monitoring treatment effects on the lowest SpO2/FiO2 ratio in the PACU.
- Trial name
- QUANTUM (NCT07084363)
- Testing
- Quantitative monitoring, Qualitative monitoring
- Where
- United States
- Volunteers
- 1,032 people
- Sponsor
- The University of Texas Health Science Center, Houston
Residual Paralysis, Post Anesthesia, Postoperative Complications
Predicting Neuromuscular Recovery in Surgical Patients Using Machine Learning
Despite emerging efforts to decrease residual paralysis and postoperative complications with the use of quantitative neuromuscular monitoring and reversal agents their incidences remain high.
- Conditions
- Residual Paralysis, Post Anesthesia, Postoperative Complications, Neuromuscular Blockade, Quantitative Neuromuscular Monitoring
- Trial name
- PINES (NCT05471882)
- Where
- 2 sites in Germany
- Volunteers
- 240,000 people
- Sponsor
- University Hospital Ulm
Neuromuscular Blockade, Postoperative Complications
Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery
The investigators will conduct a prospective, randomized trial to assess the impact of neuromuscular blockade on early (<72 hours post-ICU admission) postoperative respiratory complications in cardiac surgical patients.
- Trial name
- NCT02635542
- Testing
- Succinylcholine, Cisatracurium
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Reversal of Neuromuscular Blockade
Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis
The purpose of this study was to demonstrate in patients with myasthenia gravis (MG) undergoing thoracoscopic thymectomy faster recovery from a moderate neuromuscular block induced by rocuronium after reversal at reappearance of…
- Trial name
- NCT06436768
- Testing
- Sugammadex, Neostigmine
- Where
- 2 sites in China
- Volunteers
- 62 people
- Sponsor
- Beijing Tongren Hospital