Clinical trials: Degenerative Cervical Myelopathy
Degenerative Cervical Myelopathy, Non-myelopathic Degenerative Cervical Cord Compression
A Multicenter Registry-Based Study Across the Spectrum of Degenerative Cervical Myelopathy
This is a multicenter, prospective, longitudinal, observational registry-based study of degenerative cervical myelopathy (DCM) across the full disease spectrum, linked to a disease-specific biobank.
- Conditions
- Degenerative Cervical Myelopathy, Non-myelopathic Degenerative Cervical Cord Compression, Asymptomatic Degenerative Cervical Cord Compression, Cervical Spinal Cord Compression
- Trial name
- DCM-RB (NCT07641699)
- Testing
- Registry-based observation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wangjing Hospital, China Academy of Chinese Medical Sciences
Degenerative Cervical Myelopathy (DCM)
Cervical Laminectomy With or Without Lateral Mass Fixation in Cervical Spondylotic Myelopathy
The cervical spine consists of seven cervical vertebrae joined by intervertebral disks and a complex network of ligaments. The cervical spine has a normal lordotic curve, and it is much more mobile than the thoracic or lumbar…
- Trial name
- NCT06045663
- Testing
- laminectomy without lateral mass fixation, laminectomy with lateral mass fixation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Cervical Degenerative Disc Disease
Real World Data Collection on the Synergy Disc
This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts.
- Trial name
- NCT06383949
- Testing
- Synergy Cervical Disc system
- Where
- Ireland
- Volunteers
- 50 people
- Sponsor
- Synergy Spine Solutions
Degenerative Disc Disease
Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD
This study will evaluate the safety and effectiveness of a device called "Posterior Cervical Stabilization System or PCSS" when used along with posterior cervical fusion (PCF) in combination with anterior cervical discectomy and…
- Trial name
- FUSE (NCT04229017)
- Testing
- Anterior Cervical Discectomy and Fusion, Posterior Cervical Stabilization System (PCSS)
- Where
- 17 sites in United States
- Volunteers
- 236 people
- Sponsor
- Providence Medical Technology, Inc.
ALS, Amyotrophic Lateral Sclerosis
NYSCF Scientific Discovery Biobank
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells…
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Alzheimer Disease, Alzheimer Disease, Early Onset
- Trial name
- NCT06203106
- Testing
- Biological Sample Collection
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- New York Stem Cell Foundation Research Institute
Degenerative Cervical Myelopathy
Stimulation-based Therapy to Improve Balance in DCM
The goal of this clinical trial is to determine if a treatment called transcutaneous spinal cord stimulation (tSCS), when combined with balance training, can help improve balance in adults who have had surgery for degenerative…
- Trial name
- STIM-DCM (NCT07298460)
- Testing
- Transcutaneous spinal cord stimulation, Balance and Gait Training
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Medical College of Wisconsin
Adjacent Segment Disease, Cervical Myelopathy
Adjacent Segment Disease After Anterior Cervical Decompression Surgery
Radiculopathy and/or myelopathy due to cervical degenerative disc disease are increasingly common pathologies in our ageing population. Both can be treated non-surgically or surgically.
- Conditions
- Adjacent Segment Disease, Cervical Myelopathy, Cervical Radiculopathy, Degenerative Disc Disease
- Trial name
- ASDafterACDF (NCT04320043)
- Testing
- Anterior cervical decompression
- Where
- Netherlands
- Volunteers
- 673 people
- Sponsor
- Zuyderland Medisch Centrum
Cervical Disc Degeneration
Real World Data Collection on the Synergy Cervical Disc
This trial is a real world data (RWD) collection observational study, comprised of both prospective and retrospective arms, that will examine the safety and effectiveness of the Synergy Cervical Disc System in patients with…
- Trial name
- NCT05305430
- Testing
- Synergy Cervical Disc System
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Synergy Spine Solutions
Advanced Solid Tumors
A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors
The purpose of this study is to assess the safety and tolerability of BMS-986484 administered alone, in combination with nivolumab in participants with advanced/metastatic solid tumors including non-small cell lung cancer…
- Trial name
- NCT06544655
- Testing
- BMS-986484, Nivolumab, Oxaliplatin
- Where
- 9 sites in United States, Australia and 1 more
- Volunteers
- 213 people
- Sponsor
- Bristol-Myers Squibb
Cervical Myelopathy, Ossification of Posterior Longitudinal Ligament in Cervical Region
The Establishment of the Integration of Surgery and Postoperative Intensive Recovery of Patients With CSM
This study aims to establish the specialist consensus of the integration of posterior approach surgical treatment and postoperative intensive recovery management for CSM or OPLL patients, and verify its safety, practicability and…
- Trial name
- NCT04947891
- Testing
- Intensive recovery management
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University Third Hospital
Cervical Myelopathy
Degenerative Cervical Myelopathy Repository
To create a research repository of patients with known degenerative cervical myelopathy (DCM) and a control cohort of subjects who have non-myelopathic spinal disease.
- Trial name
- DCM (NCT05446259)
- Testing
- Standard clinical care procedures and outcome measurements.
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Francis Farhadi
Cervical Spondylotic Myelopathy
The CSM Trial: A Multicenter Study Comparing Ventral to Dorsal Surgery for Cervical Spondylotic Myelopathy
The purpose of the study is to determine the optimal surgical approach (ventral versus dorsal) for patients with multi-level cervical spondylotic myelopathy (CSM).
- Trial name
- CSM (NCT00506558)
- Testing
- Ventral Surgical Decompression with Instrumented Fusion, Dorsal Decompression With or Without Fusion
- Where
- 7 sites in United States
- Volunteers
- 103 people
- Sponsor
- Greenwich Hospital
Triple-negative Breast Cancer, NSCLC, Squamous or Non-Squamous
AN0025 and Pembrolizumab Combination in Advanced Solid Tumors
This is an open-label, multicenter, phase Ib study to evaluate the safety and preliminary efficacy of AN0025 in combination with pembrolizumab in patients with locally advanced/metastatic tumors.
- Conditions
- Triple-negative Breast Cancer, NSCLC, Squamous or Non-Squamous, Urothelial Carcinoma of the Bladder, Microsatellite Stable (MSS) Colorectal Cancer (CRC)
- Trial name
- NCT04432857
- Testing
- AN0025, Pembrolizumab
- Where
- 6 sites in United States, France
- Volunteers
- 63 people
- Sponsor
- Adlai Nortye Biopharma Co., Ltd.
Degenerative Disc Disease(DDD)
Evaluation of the Safety and Effectiveness of the CORUS™ Posterior Cervical Stabilization System 3D (PCSS 3D) for the Treatment of 2-level Cervical Degenerative Disease
The objective of this clinical trial is to evaluate the treatment of patients with two-level cervical degenerative disease using a combination of Anterior Cervical Discectomy and Fusion (ACDF) and Posterior Cervical Fusion (PCF)…
- Trial name
- SECOND (NCT07721493)
- Testing
- Circumferential Cervical Fusion (CCF), Anterior Cervical Discectomy and Fusion
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Providence Medical Technology, Inc.
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Cervical Spondylosis With Myelopathy, Degenerative Cervical Myelopathy
Quantiative MRI and Myelin-PET for the Assessment of Degenerative Cervical Myelopathy
To use advanced imaging techniques, including MRI Brain and Spinal Cord, and MRI/PET Spinal Cord to provide an assessment of Degenerative Cervical Myelopathy to improve understanding of the pathophysiology and natural history of…
- Trial name
- IMAGE-DCM (NCT05242666)
- Testing
- 3T MR Imaging of the cervical spinal cord, Positron Emission Tomography using [11C]PIB, 3T MR Imaging of the Brain
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Radiculopathy, Cervical, Myelopathy
A Study of Korean Society of Spine Surgery on the Outcomes of Anterior Cervical Discectomy and Fusion
The purpose of this study is firstly to determine the efficacy of cervical plate for anterior cervical discectomy and fusion using cervical cage, and secondly to investigate the determining factors for surgical outcomes.
- Trial name
- NCT01911013
- Testing
- anterior cervical discectomy and fusion, Cage and Plate, Cage alone
- Where
- 31 sites in South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Hospital
Radiculopathy, Cervical, Myelopathy Cervical
Pilot Study of ZetaFuse™ Bone Graft for the Treatment of Cervical Degenerative Disc Disease
The goal of this pilot clinical trial is to test the safety and preliminary performance of the ZetaFuse Bone Graft in patient requiring fusion of the C3-C7 vertebral bones due to pain or loss of neurological function.
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Neurological Abnormality, Disc Disease
- Trial name
- NCT05971329
- Testing
- Cervical Fusion (ZetaFuse™ Bone Graft)
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Zetagen Therapeutics, Inc
Cervical Myelopathy
Activity Monitors as a Measure of Physical Function in Degenerative Cervical Myelopathy
The investigators objective of this research is to compare activity monitor results with standard of care (SOC) question-based outcome measures for degenerative cervical myelopathy patients before and after treatment with…
- Trial name
- NCT04498806
- Testing
- Fitbit
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Cervical Myelopathy
Timing of Rehabilitation Following Cervical Spinal Surgery in Degenerative Myelopathy
The goal of this clinical trial is to learn whether starting rehabilitation earlier after surgery can improve recovery and is feasible and acceptable for adults with degenerative cervical myelopathy (DCM) undergoing cervical…
- Trial name
- NCT07636135
- Testing
- Physical Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta