Clinical trials: Deficiency, Vitamin C
HIV Infections
A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs
The purpose of this study is to see if certain vitamins (C, E, B1, and B2) can keep lactate levels from becoming too high in patients who are taking nucleoside reverse transcriptase inhibitor (NRTI) anti-HIV drugs.
- Trial name
- NCT00037063
- Testing
- Thiamine hydrochloride, Riboflavin, Ascorbic acid
- Where
- 4 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
The Safety and Effectiveness of Different Doses of Vitamin C in HIV-Infected Patients
This is a study to evaluate the tolerance and antiviral effect of oral vitamin C in HIV-infected.
- Trial name
- NCT00001070
- Testing
- Oral Vitamin C
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Burns, Ascorbic Acid Deficiency
Low Dose Vitamin C in Burns >20% Compared to Previous Studies With High Dose Vitamin C
Burn injury is marked by a large release of inflammatory mediators which disrupt the normal capillary barrier and cause a rapid shift of intravascular fluid into interstitial spaces, ultimately leading to shock and death.
- Conditions
- Burns, Ascorbic Acid Deficiency, Burn Shock, Burn Degree Second
- Trial name
- NCT05612867
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Arrowhead Regional Medical Center
Septic Shock
Vitamin C Deficiency in Septic Shock
Objectives: investigators aim to study the effect of addition of vitamin C as a part of treatment in septic shock patients on: Hemodynamics, Inflammation status and ICU outcome.
- Trial name
- NCT06224881
- Testing
- Ascorbic acid
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Sepsis, Septic Shock
Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa
Open-label phase 2a Randomized Controlled Trial (RCT) assessing the pharmacokinetics of two different doses of intravenous vitamin C given alongside vitamin B1 in adult medical patients with sepsis and hypotension.
- Conditions
- Sepsis, Septic Shock, HIV
- Trial name
- REVISTA-DOSE (NCT04999137)
- Testing
- Vitamin C, Vitamin B1
- Where
- 2 sites in Uganda
- Volunteers
- 60 people
- Sponsor
- Liverpool School of Tropical Medicine
Vitamin d Deficiency
The Effect of UV-C Enriched Foods on Vitamin D Deficiency
This study is an experimental design study in which demographic characteristics, food consumption, biochemical parameters and anthropometric measurements of individuals with low vitamin D levels before and after consuming…
- Trial name
- NCT06098820
- Testing
- Vitamin D status
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Okan University
Vitamin C Deficiency
The Effect of Vitamin C on Quality of Life of Terminal Cancer Patients
This study determines whether high dose vitamin C is effective for quality of life in terminal cancer patients.
- Trial name
- NCT03224572
- Testing
- high-dose vitamin C 30gm, normal saline
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus, Non-Insulin Dependent, Non-Insulin Dependent
Study of the Effects of Vitamin C on Patients With Type 2 Diabetes
Diabetes is a disease characterized by decreased sensitivity to the action on insulin to promote sugar (glucose) use and blood vessel relaxation (vasodilation) in muscle.
- Trial name
- NCT00001870
- Testing
- Acetylcholine
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Mortality, Hyperhomocysteinemia
5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients
A randomized prospective study was done to determine whether i.v. 5-methyltetrahydrofolate vs oral folate improved survival in ESRD patients. Homocysteine, CRP, Lp(a), albumin, folates, vitamin B6 and B12 were checked.
- Conditions
- Mortality, Hyperhomocysteinemia, Inflammation
- Trial name
- NCT00626223
- Testing
- 5-MTHF (5-methyltetrahydrofolate), folic acid
- Where
- Italy
- Volunteers
- 341 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Vitamin C Deficiency, Scurvy
Study of Prevalence and Risk Factors of Hypovitaminosis C in Long Term Care Unit
The clinical finding of skin rashes which appear after a vitamin C deficiency in Long Term Care Unit leads us to believe that the institutional diet could predispose to this kind of deficiency.
- Trial name
- Vitamin C (NCT03807791)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Vitamin C Deficiency, Smoking
The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients
The goal of this study is to perform a randomized clinical trial to assess the effects of vitamin C versus placebo on wound healing in mandibular fracture patients.
- Conditions
- Vitamin C Deficiency, Smoking, Surgery, Surgery--Complications
- Trial name
- NCT03938584
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Hennepin Healthcare Research Institute
Endothelial Dysfunction
A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction
This Phase 2, randomized, open-label, 2-treatment, 2-sequence, 2-period crossover, pharmacokinetic (PK) study will compare plasma concentrations of BH4 in subjects with endothelial dysfunction following 14 days of treatment by…
- Trial name
- NCT00532844
- Testing
- Sapropterin Dihydrochloride, Sapropterin Dihydrochloride and Vitamin C
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- BioMarin Pharmaceutical
Iron-deficiency
Determination of a Dose-dependent Effect of GOS on Iron Absorption, and Addition of Vitamin C
Iron deficiency is still the most common and widespread nutritional disorder in the world according to WHO. In a recent iron absorption study in adult women with low iron stores in our lab (publication under review), we found…
- Trial name
- Fe_GOS_2 (NCT03762148)
- Testing
- ferrous fumarate, ferrous sulphate, ferric pyrophosphate
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- Isabelle Herter-Aeberli
Chronic Hepatitis C
Vitamin D Deficiency in Subjects With Chronic Hepatitis C Compared to Healthy Volunteers
The objective of this study is to assess the prevalence of vitamin D deficiency in patients with chronic Hepatitis C compared to a matched control group of healthy individuals in the Sioux Falls area.
- Trial name
- NCT01274013
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Avera McKennan Hospital & University Health Center
Transplantation, Ascorbic Acid Deficiency
Observational Study on the Variation of Ascorbic Acid in Patients Undergoing Solid Organ Transplantation
The objective of this observational clinical study is to evaluate the variations in ascorbic acid during the transplantation phases and how these variations influence the oxidative status and patient outcome.
- Trial name
- REDOX-TX (NCT06395259)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Policlinico Hospital
Patient Blood Management, Cardiac Surgery
Effect of the Combined Programme on Perioperative Anaemia（CPPA）
We used the preoperative intervention of iron sucrose in combination with human erythropoietin and vitamin C as an innovative combination therapy.
- Conditions
- Patient Blood Management, Cardiac Surgery, Iron Deficiency Anemia
- Trial name
- NCT05353348
- Testing
- Iron Sucrose, recombinant human erythropoietin, ascorbic acid, conventional treatment
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Vitamin C Deficiency
The Effect of Liposome Vitamin C on the Absorption and Metabolism of the Human Body.
To evaluate the difference between vitamin C in the form of oral liposomes and general vitamin C in a fixed period of time in plasma and urine.
- Trial name
- NCT04886752
- Testing
- vitamin C without liposome, liposomal process A vitamin C, liposomal process B vitamin C (Double Nutri™)
- Where
- Taiwan
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Hypovitaminosis, Vitamin C Abnormal
Vitamin C 4 Care Homes
Older people in care homes are one of the most vulnerable groups with respect to risk, morbidity and mortality of severe coronavirus disease-2019 (COVID-19).
- Trial name
- VITA-C4CARE (NCT05122481)
- Testing
- Vitamin C
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Aberdeen
Haematopoiesis
A Study to Demonstrate the Efficacy and Tolerability of Ferrous Bisglycinate Chelate in Iron Deficiency Anaemia and to Compare These With Those of Ferrous Ascorbate.
Iron deficiency anaemia (Haemoglobin, Hb < 12gm/dl) is one of India's major public health problems particularly in women. Effective control of iron deficiency anaemia decreases the incidence of fatigue, bodyache, headache, lack…
- Trial name
- NCT01160198
- Testing
- ferrous ascorbate, ferrous bisglycinate chelate 1 OD, ferrous bisglycinate chelate 2 OD
- Where
- 7 sites in India
- Volunteers
- 271 people
- Sponsor
- GlaxoSmithKline
Hyperhomocysteinemia, Hyperlipoproteinemias
Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms.
This randomized, double-blind, placebo-controlled trial will evaluate the impact of methylfolate, pyridoxal-5'-phosphate (P5P), and methylcobalamin supplementation on homocysteine and LDL-C levels in individuals with low to…
- Trial name
- VITAGEN-H (NCT06163443)
- Testing
- Vitamin B
- Where
- Russia
- Volunteers
- 54 people
- Sponsor
- S.LAB (SOLOWAYS)