Clinical trials: Deep Sedation
Deep Sedation
Dexmedetomidine Sedation in Children Before MRI Examinations
Dexmedetomidine, has been used in the past 4-5 years as an alternative sedation method for children at the pediatric radiology department in order to reduce the waiting lists and the use of general anesthesia with its risks and…
- Trial name
- NCT05163704
- Testing
- Dexmedetomidine
- Where
- Sweden
- Volunteers
- 1,091 people
- Sponsor
- Karolinska University Hospital
Anesthesia, Deep Sedation
Intranasal Dexmedetomidine Sedation at Dose of 2 mcg/kg Versus 4 mcg/kg in Children Undergoing MRI
This study aimed to compare the effectiveness of intranasal Dexmedetomidine sedation at Dose of 2 mcg/kg and 4 mcg/kg in Children Undergoing MRI at Cipto Mangunkusumo Hospital
- Conditions
- Anesthesia, Deep Sedation, Magnetic Resonance Imaging, Pediatric ALL
- Trial name
- NCT05091151
- Testing
- Intranasal dexmedetomidine at dose of 2 mcg/kg and 4 mcg/kg
- Where
- Indonesia
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Bidirectional Endoscopy, Deep Sedation
The Optimal Sequence in Same-day Bidirectional Endoscopy Under Deep Anesthesia.
The purpose of this study is to explore the optimal sequence of same-day bidirectional endoscopy under deep anesthesia induced by propofol combined with fentanyl.
- Trial name
- NCT04973878
- Testing
- EGD first, Colonoscopy first
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Moderate Sedation, Deep Sedation
Sedation and Neuromediators Concentration
Propofol (Propofol Kabi, Registration number from the State Register of Medicines - 000875) is a widely used intravenous anesthetic.
- Trial name
- NCT04695509
- Testing
- moderate propofol sedation (Bispectral index monitoring 70-90; The Richmond Agitation and Sedation scale (RASS) "-2" - "-3", deep propofol sedation (BIS 60-70, The Richmond Agitation and Sedation scale (RASS) "-4")
- Where
- Russia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Deep Sedation, Intensive Care Pediatric
Pharmacokinetic Analysis of Midazolam and Fentanyl in Pediatric Patients With Long-term Analgosedation
Pharmacokinetic monitoring of midazolam, it's active metabolite and fentanyl in pediatric patients with long-term analgosedation will be performed.
- Trial name
- Morpheus (NCT02302391)
- Testing
- PK analysis
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Palliative Care, Deep Sedations
Prevalence of Deep Sedation in Terminal Palliative Phase
This nation-wide, multicentric, prospective and cross-sectional study aims to estimate the prevalence of deep sedations (i.e. with a -4 or -5 score at the Richmond scale at the induction time) for patients in terminal phase and…
- Trial name
- PREVAL-S2P (NCT04333719)
- Testing
- Type of sedations
- Where
- France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Bordeaux
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Morbid Obesity, Noninvasive Ventilation
Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
This study evaluates the ability of high flow nasal cannula versus nasal cannula to oxygenate morbidly obese patients undergoing moderate to deep sedation for gastrointestinal procedures.
- Conditions
- Morbid Obesity, Noninvasive Ventilation, Deep Sedation
- Trial name
- NCT02859597
- Testing
- High flow nasal cannula, Nasal Cannula
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Deep Sedation
Comparison of Oxygenation Methods in Sedation
Abstract Backgrounds and objectives: Dental treatments, especially in children who can not be cooperated, may require deep sedation due to intense anxiety and fear.
- Trial name
- NCT03893877
- Testing
- nasal cannula, nasal mask
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Esophagogastroduodenoscopy, Deep Sedation
The Influence of Sedation for Endoscopy on Cognitive Function
It is commonly recommended that patients should refrain from driving for 24 hours after sedation for endoscopy，however，this recommendation has been queried recently．To investigate the effect of sedation on early postoperative…
- Conditions
- Esophagogastroduodenoscopy, Deep Sedation, Cognition Disorders
- Trial name
- NCT04168294
- Testing
- Propofol, endoscopy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Endotracheal Intubation, Deep Sedation
Inhaled Sedation Using the Anesthetic-conserving Device ( ANACONDA) in Prehospital Emergency Medecine.
Achieving the optimal sedation level for patient management is not always possible using our standard intravenous medications in Pre-hospital Emergency medicine.
- Trial name
- ANACONDA (NCT04141267)
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Noninvasive Ventilation, Respiratory Insufficiency
The Effect of High-flow Nasal Oxygenation to the Saturation During Analgo-sedation in Different ASA Risk Class Patients
Analgo-sedation is standard procedure in anesthesiology practice and is often given for colonoscopy in the setting of daily hospital.
- Conditions
- Noninvasive Ventilation, Respiratory Insufficiency, Deep Sedation, Hypoxia
- Trial name
- NCT03687385
- Testing
- high-flow nasal oxygenation (HFNO), low-flow nasal oxygenation (LFNO)
- Volunteers
- 126 people
- Sponsor
- Anita Vukovic
Noninvasive Ventilation, Respiratory Insufficiency
Can High-flow Nasal Oxygenation Improve Oxygen Saturation During Analgo-sedation in Obese Adults?
Obesity is omnipresent problem in everyday anesthesiology practice associated with low level of blood oxygen (hypoxemia) during analgo-sedation.
- Conditions
- Noninvasive Ventilation, Respiratory Insufficiency, Obesity, Deep Sedation
- Trial name
- NCT03687424
- Testing
- high-flow nasal oxygenation (HFNO), low-flow nasal oxygenation (LFNO)
- Volunteers
- 126 people
- Sponsor
- University of Split, School of Medicine
Coil Treatment, Deep Sedation
What Should be the Anesthesia Method in Endobronchial Coil Treatment
This prospective, randomize study was conducted in a university hospital. Bronchoscopic lung volume reduction (BLVR) coil treatment has recently been introduced into clinical practice as an alternative for patients chronic…
- Trial name
- NCT03652324
- Testing
- method
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- TC Erciyes University
Deep Sedation, Anesthesia, General
Addition of Nitrous Oxide and Its Effects on Depth of Anesthesia
The study hypothesizes that adding 60% nitrous oxide to a steady state sevoflurance or propofol anesthetic will lead to a decrease in both BIS and Entropy indices during a constant level of surgical stimulus
- Trial name
- N20 (NCT00717574)
- Testing
- Sevoflurane group, Propofol group
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Oklahoma
Oxygen Administration During Deep Sedation
Nasopharyngeal Versus Nasal Cannula Oxygen Supplementation in Surgery Patients
The investigators plan to conduct a randomized, controlled trial comparing nasopharyngeal oxygen supplementation to traditional nasal cannula in patients undergoing oral surgery under moderate sedation.
- Trial name
- NCT02219464
- Testing
- Nasopharyngeal catheter, Nasal Cannula, Oxygen Supplementation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Deep Sedation
Use of Dexmedetomidine in Children Undergoing Cardiac Surgery
The aim of the study is to evaluate the efficacy of dexmedetomidine in reducing the need for sedatives and analgesics in the immediate post-operative period in children who underwent surgical correction of complex congenital…
- Trial name
- NCT02375243
- Testing
- dexmedetomidine
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Cholangiopancreatography, Endoscopic Retrograde, Mortality
Mortality After Endoscopic Retrograde Cholangiopancreatography
In this study, the investigators aimed to overview patients with specific and non-specific complications who admitted to intensive care unit following endoscopic retrograde cholangiopancreatography and had fatal course in the…
- Conditions
- Cholangiopancreatography, Endoscopic Retrograde, Mortality, Deep Sedation
- Trial name
- NCT02983331
- Testing
- complications during procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 1,471 people
- Sponsor
- Gulsah Karaoren
Moderate, Deep Sedation
Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children
There is a wide variation of published IV ketamine dosing regimens used for procedural sedation in children in the Emergency Department (ED).
- Trial name
- NCT02519595
- Testing
- Ketamine IV 1mg/kg, Ketamine IV 1.5mg/kg, Ketamine IV 2mg/kg
- Volunteers
- 182 people
- Sponsor
- Children's Hospital of Michigan
Deep Sedation
Bispectral Index Monitoring To Guide Sedation In The Critical Care Setting
A randomized, control trial to compare the total dose of sedatives use in patients over 65 years admitted to the intensive care unit, guiding sedation by monitoring with BIS® versus monitoring with the exclusive use of sedation…
- Trial name
- BIS65 (NCT02909010)
- Testing
- BIS™ Brain Monitoring System, RASS
- Volunteers
- 150 people
- Sponsor
- Hospital Universitari de Bellvitge