Clinical trials: Deep Brain Stimulation
PD - Parkinson's Disease
Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease
The purpose of this study is to test a new way to treat Parkinson's disease (PD). Subjects will be implanted with deep brain stimulator (DBS) devices and electrodes placed under the scalp.
- Trial name
- Subgaleal aDBS (NCT07398157)
- Testing
- Medtronic Percept Deep Brain Stimulation (cDBS), Medtronic Percept Deep Brain Stimulation (daytime aDBS), Medtronic Percept Deep Brain Stimulation (nighttime aDBS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Bipolar Depression
Deep Brain Stimulation of Treatment-Resistant Bipolar Depression
This study is only enrolling at Baylor College of Medicine. The other research locations listed serve to support data analysis only.
- Trial name
- DBS in TRBD (NCT06599099)
- Testing
- Medtronic Percept RC System, One Month Blinded Discontinuation Period
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Wayne Goodman MD
Older Adults (60 - 85 Years Old), Mild Cognitive Impairment (MCI)
Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory
A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities.
- Trial name
- DEEPBRAIN (NCT07560904)
- Testing
- Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz), Control striatal stimulation, Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (60 Hz)
- Where
- Czechia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Parkinson's Disease
Deep Brain Stimulation Therapy in Movement Disorders
Background: In deep brain stimulation (DBS), a device called a neurostimulator is placed in the chest. It is attached to wires in parts of the brain that affect movement.
- Trial name
- NCT02119611
- Testing
- Deep Brain Stimulation management
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dexmedetomidine, Deep Brain Stimulation
Dexmedetomidine on Basal Ganglia Neuronal Activity in Parkinson's Disease
The implantation of a deep brain stimulator (DBS) is an established option to improve the symptoms of Parkinson's disease (PD) in patients that do not respond adequately to medical therapy.
- Conditions
- Dexmedetomidine, Deep Brain Stimulation, Parkinson Disease
- Trial name
- NCT02982512
- Testing
- Dexmedetomidine
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Parkinson Disease
Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes.
- Trial name
- NCT05933681
- Testing
- Neural recordings and stimulation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson's Disease With Deep Brain Stimulation
Parkinstep: Automated PD Gait and Balance Assessment for Optimizing DBS
Changes in deep brain stimulation (DBS) settings can have a delayed effect on gait function, which makes it impractical to optimize DBS for gait parameters in the clinic.
- Trial name
- NCT02080572
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Parkinson's Disease
Attributional Style and Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disorder affecting 1-2% of the population over 65 years-old. In addition to the motor impairment characterized by resting tremor, bradykinesia, rigidity and postural…
- Trial name
- ParkAIHQ (NCT03371277)
- Testing
- Medical visit for specific questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CHU de Reims
Parkinson Disease, Deep Brain Stimulation
Effect of Mediterranean Diet on Nutrition in Parkinson's Disease Patients With Bilateral Subthalamic Deep Brain Stimulation
The goal of this clinical trial is to evaluate whether Mediterranean diet can help manage body weight and improve body composition in adult Parkinson's disease patients who have undergone bilateral subthalamic nucleus deep brain…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Deep Brain Stimulation Surgery
- Trial name
- NCT07187739
- Testing
- Mediterranean diet
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara University
Spinocerebellar Ataxia Genotype Type 1, Spinocerebellar Ataxia Genotype Type 3
Cerebellar DBS in SCA1 and SCA3 Study
The purpose of this study is to evaluate the safety and feasibility of deep brain stimulation (DBS) in the deep cerebellar nuclei (DCN) in patients with Spinocerebellar Ataxia (SCA) types 1 and 3.
- Trial name
- NCT07752095
- Testing
- UG3NS140720 Deep Brain Stimulation System
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Gordon H. Baltuch
Parkinson's
Nurse Management of Neuromodulation Therapy
The central hypothesis is that the use of a DBS (Deep Brain Stimulation) clinical decision support system for individual patient management will enable considerable time savings compared to standard care.
- Trial name
- DBS (NCT02177149)
- Testing
- Standard of Care, DBS using Clinical Support System.
- Sponsor
- Medical College of Wisconsin
Stroke, Dysarthria
Deep Brain Stimulation + Therapy for Stroke
The purpose of this study is to evaluate the safety and potential benefits of combining deep brain stimulation (DBS) with targeted speech and swallowing rehabilitation in individuals who have experienced a stroke and have…
- Conditions
- Stroke, Dysarthria, Apraxia, Dysphagia
- Trial name
- NCT07849114
- Testing
- Boston Scientific Vercise Deep Brain Stimulation (DBS) System, Rehabilitation Training Protocol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Pirondini, Elvira, PhD
Parkinson Disease
An Open-label Clinical Trial to Compare the Safety and Effectiveness of Adaptive Versus Conventional Deep Brain Stimulation
The clinical trial aims to evaluate the safety and effectiveness of bilateral subthalamic nucleus (STN) and Globus Pallidus internus (GPi) deep brain stimulation (DBS) with the AlphaDBS IPG System when programmed in adaptive…
- Trial name
- ADVENT (NCT05262348)
- Testing
- adaptive DBS delivered through AlphaDBS IPG System, conventional DBS delivered through AlphaDBS IPG System
- Sponsor
- Newronika
Pain
Analgesic Effects of Expectation and Deep Brain Stimulation in Patients With Parkinson's Disease
The study investigates analgesic effects of expectations and deep brain stimulation on chronic and evoked pain in patients with Parkinson's disease.
- Trial name
- NCT04151043
- Testing
- Suggestions, Deep brain stimulation
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
Parkinson Disease, Deep Brain Stimulation
Study on Brain Network Mechanism of Deep Brain Stimulation for Parkinson's Disease
As a surgical intervention, DBS can effectively relieve PD tremor, rigidity, bradykinesia and other symptoms. How to better screen patients suitable for DBS treatment and conduct reasonable preoperative and postoperative…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Non-motor Symptoms
- Trial name
- NCT05959161
- Testing
- DBS
- Volunteers
- 100 people
- Sponsor
- Tianjin Huanhu Hospital
Parkinson Disease
Early Versus Late Application of STN DBS to PD Patients With Motor Complications
Although deep brain stimulation of the subthalamic nucleus(STN DBS) has become the surgical treatment of choice for Parkinson's disease(PD), a consensus on the timing of surgery is lacking.
- Trial name
- ELASS (NCT01922388)
- Testing
- Bilateral deep brain stimulation of the subthalamic nucleus
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chen Ling
Parkinson's Disease, Mild Cognitive Impairment
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
The goal of this clinical trial is to evaluate the safety and tolerability of a novel deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Nucleus Basalis of Meynert (NBM) to treat cognitive and cognitive-motor…
- Trial name
- NCT05968703
- Testing
- Combined STN+NBM DBS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Helen M. Bronte-Stewart
Parkinson's Disease
INfusion VErsus STimulation in Parkinson's Disease
Both Continuous intrajejunal Levodopa Infusion (CLI) and Deep Brain Stimulation (DBS) are accepted therapies for the treatment of advanced Parkinson's disease (PD). To date, no comparative studies have been executed.
- Trial name
- INVEST (NCT02480803)
- Testing
- Continuous intrajejunal infusion of levodopa-carbidopa, deep brain stimulation
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Parkinson's Disease
Cont. of a Study to Evaluate Implanting Peripheral Nerve Grafts Into Subjects With Parkinson's Disease (PD) During DBS
This pilot study is designed to follow up on a previous, preliminary study and test the long-term safety and feasibility of the implantation of autologous peripheral nerve grafts into the substantia nigra, basal forebrain…
- Trial name
- CAPNG (NCT02369003)
- Testing
- Autologous Peripheral Nerve Graft
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Craig van Horne, MD, PhD
Parkinson Disease
Role of Deep Brain Stimulation on Social Cognition in Parkinsonian Patients
Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life.
- Trial name
- NCT03004573
- Testing
- Neuropsychological detailed tests with focus on social cognition
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hospices Civils de Lyon