Clinical trials: Deep Brain Stimulation
Essential Tremor
Deep Brain Stimulation Effects in Essential Tremor
Deep Brain Stimulation (DBS) is an effective therapy for patients with medically refractory essential tremor. However, DBS programming is not standardized and multiple clinic visits are frequently required to adequately control…
- Trial name
- NCT04581941
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Florida
Cocaine Addiction
Deep Brain Stimulation of the Sub-Thalamic Nucleus to Treat Severe and Treatment-resistant Cocaine Addiction.
Cocaine addiction is a chronic condition with severe cardiac, neurologic, psychiatric and social complications. Cocaine is the second most consumed illicit drug in France.
- Trial name
- STUC (NCT02892851)
- Testing
- Deep brain stimulation of the subthalamic nuclei (STN-DBS)
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Subthalamic Nucleus Stimulation Effect on Gait Symmetry and Freezing of Gait
Impact of unilateral modulation of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease
- Trial name
- STIMSYM (NCT02704195)
- Testing
- Unilateral reduction of stimulation, Chronic Subthalamic nucleus stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Grenoble
Alzheimer's Disease
Chronic Electrical Stimulation of Hypothalamus/Fornix in Alzheimer's Disease
Alzheimer's Disease (AD) is the most common cause of dementia for which no treatment has shown consistent efficacy to stop or slow down the disease.
- Trial name
- NCT00888056
- Testing
- Bilateral chronic electrical stimulation of the hypothalamus/fornix
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Parkinson Disease
Follow Up Study for Treatment of Parkinson's Disease With Subthalamic Deep Brain Stimulation
This study aims to evaluate the long term effect of deep brain stimulation in the the subthalamic nucleus (STN) in patients with Parkinson's disease.
- Trial name
- NCT03230331
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
Deep Brain Stimulation (DBS) for Parkinson's Disease International Study
To gather data on DBS Therapy effectiveness in different geographic populations.
- Trial name
- REACH-PD (NCT02937688)
- Testing
- Medtronic DBS Therapy for Parkinson's disease
- Where
- 15 sites in Brazil, China
- Volunteers
- 212 people
- Sponsor
- MedtronicNeuro
Dystonia, Generalized Primary Dystonia
Deep Brain Stimulation for Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) in treating primary generalized dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal…
- Trial name
- NCT00105430
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia, Deep Brain Stimulation
Dystonia Image-based Programming of Stimulation: A Prospective, Randomized, Double-blind Crossover Trial
The primary objective of this exploratory study is to prospectively evaluate the feasibility of image-guided programming of pallidal deep brain stimulation (DBS) for dystonia.
- Trial name
- DIPS (NCT05097001)
- Testing
- DBS programming
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Wuerzburg University Hospital
Parkinson Disease
Combined Deep Brain Stimulation in Parkinson's Disease
The study is a pilot study on Parkinson's disease patients to evaluate Combined deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus for unresponsive freezing of gait.
- Trial name
- SCP-FOG (NCT05415774)
- Testing
- 1 : S-C1-C2, 2 : S-C2-C1, 3 : C1 - S - C2
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Parkinson's Disease (PD), Deep Brain Stimulation
Coordinated Reset Deep Brain Stimulation for Parkinson's Disease
Deep brain stimulation (DBS) is a surgical implant procedure for the treatment of Parkinson's Disease (PD) utilizing medical devices approved by the FDA.
- Trial name
- CR DBS PD (NCT07340073)
- Testing
- DBS
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Dystonia, Movement Disorder
Efficacy and Safety of Deep Brain Stimulation (DBS) of the Pallidal (GPi) in Patients With Tardive Dystonia
The purpose of this randomized, double blind, multi-center study is to assess the efficacy and safety of bilateral pallidal deep brain stimulation in patients with tardive dystonia.
- Trial name
- NCT00331669
- Testing
- deep brain stimulation
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Charite University, Berlin, Germany
Parkinson Disease
Physical Therapy and Deep Brain Stimulation in Parkinson Disease
While deep brain stimulation of the subthalamic nucleus (STN-DBS) is commonly used to reduce tremor, muscle stiffness, and bradykinesia in people with Parkinson disease (PD), preliminary studies suggest balance may worsen and…
- Trial name
- PTDBS (NCT03181282)
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder
Amygdala MRI-TIS for Depression
The study utilizes a non-invasive deep brain stimulation (temporal interference, TI) technique primarily targeting the amygdala to preliminarily explore the clinical efficacy and potential mechanisms of MRI-compatible TI…
- Trial name
- NCT06461260
- Testing
- Nervio-X
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder
The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat refractory obsessive-compulsive disorder (OCD).
- Trial name
- NCT06660225
- Testing
- Medtronic Percept Deep Brain Stimulation Therapy [Therapeutic stimulation]
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nader Pouratian
Obsessive-Compulsive Disorder
Refining the Target for Deep Brain Stimulation (DBS) in Severe, Treatment Refractory Obsessive Compulsive Disorder (OCD)
In select, therapy resistent patients with Obsessive Compulsive Disorder (OCD) Deep Brain Stimulation (DBS) has been used as a treatment.
- Trial name
- NCT01985815
- Testing
- VC/VS stimulation
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson's Disease Stutter
Parkinsonian Sutter
The research team aims to provide evidence of Parkinsonian (PD) Stutter management by addressing the primary neurological issue in this disorder using Deep Brain Stimulation (DBS).
- Trial name
- NCT06093399
- Testing
- System ON, System OFF
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Parkinson's Disease, With Inclusion Criteria for STN Deep Brain Stimulation
Evaluation of the Safety and Efficacy of Bilateral Subthalamic Nucleus (SNT) Radiosurgery in Idiopathic Severe Parkinson's Disease Fulfilling Inclusion Criteria for STN Deep Brain Stimulation and Presenting With a Contraindication to Intracerebral Electrode Implantation.
The goal of our trial is to evaluate the tolerance and efficacy of the STN radiosurgery in Parkinsonian patients presenting with the inclusion criteria for the STN stimulation but presenting also with clear contraindications to…
- Conditions
- Parkinson's Disease, With Inclusion Criteria for STN Deep Brain Stimulation, Presenting a Contraindication to Intracerebral Electrode Implantati
- Trial name
- NCT01284699
- Testing
- Gamma Knife radiosurgery
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Parkinson Disease
Novel Paradigms of Deep Brain Stimulation for Movement Disorders
Investigators will enroll patients who are already selected to undergo deep brain stimulation surgery based on standard of care.
- Trial name
- NCT04563143
- Testing
- Novel DBS Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The Cleveland Clinic
Parkinson's Disease
Deep Brain Stimulation Effects on Gait and Balance in Patients With Parkinson's Disease
The purpose of this study is to evaluate the effect of Deep Brain stimulation (DBS) on walking in patients with Parkinson's disease that have had DBS.
- Trial name
- NCT02022735
- Testing
- Deep Brain Stimulator
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Miami
Parkinson's Disease
INfusion VErsus STimulation in Parkinson's Disease
Both Continuous intrajejunal Levodopa Infusion (CLI) and Deep Brain Stimulation (DBS) are accepted therapies for the treatment of advanced Parkinson's disease (PD). To date, no comparative studies have been executed.
- Trial name
- INVEST (NCT02480803)
- Testing
- Continuous intrajejunal infusion of levodopa-carbidopa, deep brain stimulation
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)