Clinical trials: Deep Brain Stimulation
Obsessive-Compulsive Disorder
The Efficacy and Safety of ALIC/NAcc-DBS for Treatment-refractory OCD
The present study aims to explore the efficacy and safety of DBS targeted the combination of the anterior limb of internal capsule and nucleus accumbens (ALIC/NAcc-DBS) to refractory OCD, based on multicenter, randomized…
- Trial name
- NCT04967560
- Testing
- deep brain stimulation
- Where
- 7 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Obsessive-Compulsive Disorder (OCD)
DBS for Treatment-resistant Obsessive-compulsive Disorder
The primary purpose of this study is to investigate the effect of deep brain stimulation (DBS) implantation targeting the anteromedial region of subthalamic nucleus (amSTN), or nucleus accumbens (NAc), or bed nucleus of the stria…
- Trial name
- NCT06360991
- Testing
- Deep brain stimulation (DBS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Tourette Syndrome, Deep Brain Stimulation
Multitarget Stereotactic Electrophysiological Recording and Stimulation for Tourette Syndrome
The goal of this clinical trial is to investigate the neural mechanisms underlying Tourette syndrome (TS) and see if personalized deep brain stimulation (DBS) can help reduce tics in TS patients and improve related issues like…
- Trial name
- MASTERS-TS (NCT06889480)
- Testing
- New Target DBS, CM-DBS
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Beijing Tiantan Hospital
Binge Eating Disorder, Obesity
Binge Eating Disorder and Obesity : Functional MRI Study
Obesity, defined as BMI> 30kg / m2, is a major public health problem, with devastating medical and psychological consequences. 30% of obese suffer from BED type of eating disorders.
- Trial name
- BED (NCT02868619)
- Testing
- Functional MRI, ADO-BEDS scale, R-CMAS scale
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Parkinson Disease
Temporally Optimized Patterned Stimulation (TOPS®) Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
This study will test newly developed stimulation settings called Temporally Optimized Patterned Stimulation or TOPS, which can be used with an already implanted deep brain stimulation system.
- Trial name
- TOPS (NCT04390867)
- Testing
- TOPS1 DBS, TOPS2 DBS, TOPS3 DBS
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Deep Brain Innovations LLC
Parkinson Disease
Deep Brain Stimulation in Parkinson's Disease: Motor and Functional Outcomes
Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative condition characterized by classic motor symptoms, such as bradykinesia, rigidity, resting tremor, and postural instability, which directly compromise the…
- Trial name
- NCT07567599
- Testing
- Deep Brain Stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Epilepsy, Lennox-Gastaut Syndrome, Intractable
Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot
The CADET Pilot will investigate the safety and feasibility of deep brain stimulation (DBS) to treat children with Lennox-Gastaut syndrome using a novel DBS device (Picostim DyNeuMo-1).
- Trial name
- CADET Pilot (NCT05437393)
- Testing
- Deep brain stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 4 people
- Sponsor
- University College, London
Major Depressive Disorder, Treatment Resistant Depression
Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation
Major depressive disorder (MDD) is a complex and severe mental illness, characterized by multiple symptoms, and is a leading cause of non-fatal health loss.
- Trial name
- NCT06542094
- Testing
- Deep Brain stimulation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- West China Hospital
Parkinson's Disease, Non-motor Symptoms
Objective Assessment of Behavioural Disorders in PD
The aim of this project is to measure behavioural disorders in Parkinson's disease (PD) patients in a more objective way, in order to facilitate the detection of those symptoms and improve the treatment of non-motor symptoms in…
- Trial name
- TECHNO-PARK (NCT04611581)
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Obesity
Deep Brain Stimulation for Human Morbid Obesity
The burden of morbid obesity to the circulatory, endocrine, and locomotor systems, as well as the psychological effects and related health-care costs, are well established in the medical literature.
- Trial name
- BLESS (NCT02232919)
- Testing
- Deep Brain Stimulation
- Where
- Brazil
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hospital do Coracao
Severe Permanent Uni or Bilateral Non-pulsatile Tinnitus, Without Associated Vestibular Pathology
Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS)
This pilot study aims at evaluating the effectiveness of the treatment of unilateral or bilateral, non-pulsatile, disabling, tinnitus, without vestibular dysfunction, using Deep Brain Stimulation (DBS) of the parieto-insular…
- Conditions
- Severe Permanent Uni or Bilateral Non-pulsatile Tinnitus, Without Associated Vestibular Pathology, Resistant to Therapeutic Failure, With or Without Hearing Loss
- Trial name
- TINNOP3-DBS (NCT04296097)
- Testing
- DBS
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Grenoble
Parkinson Disease
Data-Driven Characterization of Neuronal Markers During Deep Brain Stimulation for Patients With Parkinson's Disease
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has developed into a standard therapy in the refractory stage of Parkinson's disease (PD).
- Trial name
- NCT03079960
- Testing
- Electrophysiological recording and measurement devices
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Prof. Dr. Volker Arnd Coenen
Tourette Syndrome
A Trial of Bilateral Deep Brain Stimulation to the Globus Pallidus Internum in Tourette Syndrome
The purpose of this study is to investigate whether deep brain stimulation (DBS) of the globus pallidus internum (GPi) can alleviate tics in Gilles de la Tourette syndrome (GTS) and whether this treatment has any influence on…
- Trial name
- NCT01647269
- Testing
- Bilateral GPi Deep Brain Stimulation
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University College, London
Parkinson Disease
Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines
Twenty-five participants with PD utilizing the Medtronic Percept PC DBS system will be enrolled for this project and complete a single bout of both FE and VE.
- Trial name
- NCT05972759
- Testing
- Forced and voluntary exercise
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Parkinson's Disease, Mild Cognitive Impairment
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
The goal of this clinical trial is to evaluate the safety and tolerability of a novel deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Nucleus Basalis of Meynert (NBM) to treat cognitive and cognitive-motor…
- Trial name
- NCT05968703
- Testing
- Combined STN+NBM DBS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Helen M. Bronte-Stewart
Treatment Resistant Depression, Epilepsy
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for…
- Trial name
- NCT05418894
- Testing
- Device: Directional Deep Brain Stimulation
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Parkinson's Disease (PD)
Phase I Clinical Study of NouvNeu001 Injection for the Treatment of Moderate-to-Advanced Parkinson's Disease in Patients Who Have Previously Undergone Deep Brain Stimulation or Deep Brain Nucleus Lesioning Surgery
This clinical trial is designed to evaluate the safety, tolerability and preliminary efficacy of a single injection of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in patients with Parkinson's Disease who have…
- Trial name
- NCT07550374
- Testing
- NouvNeu001 injection
- Where
- China
- Volunteers
- 10 people
- Sponsor
- iRegene Therapeutics Co., Ltd.
Parkinson's Disease, Essential Tremor
Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation
To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate for awake, DBS surgery has no significant effect on electrophysiological parameters of DBS micro-electrode recordings
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT00608231
- Testing
- Dexmedetomidine Hydrochloride Infusion, Normal Saline
- Where
- United States
- Sponsor
- Vanderbilt University
PD - Parkinson's Disease
EC50 of Dexmedetomidine in Deep Brain Stimulation Implantation of Patients With Parkinson's Disease
Dexmedetomidine (DEX) sedation is widely used in deep brain stimulation implantation (DBSI) of patients With Parkinson's disease.
- Trial name
- NCT05376761
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Tiantan Hospital
Tourette Syndrome
Deep Brain Stimulation in Forel's H Field in Tourette's Syndrome
Tourette's Syndrome (TS) is a neurodevelopmental disease characterized tics that start before the age of 18 years. About 5% of cases do not respond to drug treatment and can be classified as refractory and in these cases surgical…
- Trial name
- NCT04342754
- Testing
- Deep Brain Stimulation (DBS)
- Where
- Brazil
- Volunteers
- 8 people
- Sponsor
- University of Sao Paulo General Hospital