Clinical trials: Decompensated Heart Failure
Decompensated Heart Failure
Speckle Tracking Echocardiography Adds Information in Decompensated Heart Failure
The overall objective of the study is to determine whether speckle tracking echocardiography presents additional prognostic value to the routine assessment (clinical and echocardiographic) in patients admitted with acute…
- Trial name
- STRAIN-DHF (NCT03009552)
- Testing
- speckle tracking echocardiography
- Where
- Brazil
- Volunteers
- 176 people
- Sponsor
- Marco Stephan Lofrano Alves
Heart Failure
Application of Nanotechnology and Chemical Sensors for Diagnosis of Decompensated Heart Failure by Respiratory Samples
Application of Nanotechnology and Chemical Sensors for Diagnosis of Decompensated Heart Failure by Respiratory Samples. Breath testing, which links specific volatile molecular biomarkers in exhaled breath to medical conditions…
- Trial name
- NCT03083717
- Testing
- Collection of breath samples, followed by analysis of exhaled breath using nanomaterial-based sensors (NaNose)
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Acute Heart Failure
Clinical Outcomes of Dapagliflozin in Acute Heart Failure With Reduced Ejection Fraction (CODA-HFrEF)
The goal of this clinical trial is to evaluate the short-term clinical outcomes of starting Dapagliflozin on the same day of hospital admission in patients with acute decompensated heart failure (ADHF) with reduced ejection…
- Trial name
- NCT06012279
- Testing
- Dapagliflozin 10mg Tab
- Where
- 2 sites in Egypt
- Volunteers
- 117 people
- Sponsor
- Cairo University
Heart Failure, Congestive
Heart Failure Registry
The purpose of this registry is to compile a large clinical database on the medical management of patients hospitalized with acute heart failure, using information collected from acute care hospitals across the United States.
- Trial name
- NCT00530426
- Volunteers
- 150,000 people
- Sponsor
- Scios, Inc.
Heart Failure, Acute Decompensated Heart Failure
Use of POC Pocket Ultrasound in the Estimation of Left and Right Atrial Pressures
This study will assess the reliability of POC ultrasound in estimating right and left atrium pressures in patients with acute decompensated heart failure.
- Trial name
- POCUSP (NCT03897647)
- Testing
- General Electric (GE) VScan
- Sponsor
- Montefiore Medical Center
Heart Failure
Intensive Prevention Program After Decompensated Heart Failure
Introduction: Care for patients with heart failure (HF) often remains inadequate, even though a variety of treatment options exist.
- Trial name
- IPP-HF (NCT07472660)
- Testing
- Web-based patient portal for self learning about heart failure
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Herzzentrum Bremen
Heart Failure, Congestive
FUSION I Assesses Safety and Tolerability of Two Doses of NATRECOR (Nesiritide) Administered to Patients With Worsening Congestive (Decompensated) Heart Failure Who Are Concurrently Receiving Their Usual Cardiac Medications and Are at High Risk for Hospitalization.
The purpose of this study is to assess the safety and tolerability of two doses of nesiritide (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure) when administered…
- Trial name
- NCT00270361
- Testing
- nesiritide, usual long term cardiac medications
- Volunteers
- 214 people
- Sponsor
- Scios, Inc.
Acute Decompensated Heart Failure
The Clinical Study of the Safety and Efficacy of Istaroxime in Treatment of Acute Decompensated Heart Failure
To assess the safety, tolerability and efficacy of two different doses of istaroxime, a new agent with lusitropic and inotropic activities that improves the cardiac contraction-relaxation cycle.
- Trial name
- NCT02617446
- Testing
- Istaroxime
- Where
- 11 sites in China, Italy
- Volunteers
- 120 people
- Sponsor
- Windtree Therapeutics
Heart Failure, Congestive
ZP120 Add-on to Furosemide in Treatment of Acute or Sub-Acute Decompensated Heart Failure
The main purpose of this study is to see if the experimental drug ZP120, when given with the approved drug furosemide to patients with acute or sub-acute heart failure, can reduce the amount of fluid in the patients' lungs and…
- Trial name
- NCT00283361
- Testing
- ZP120, I.v. catherization, 6-minutes walk performance
- Where
- 22 sites in United States
- Volunteers
- 130 people
- Sponsor
- Zealand Pharma
Congestive Heart Failure, Low Cardiac Output
Losartan in Decompensated Heart Failure
The dual blockade of the renin-angiotensin-aldosterone system with an angiotensin-converting enzyme inhibitor and an angiotensin-receptor blocker used together in heart failure patients has been demonstrated to be beneficial.
- Trial name
- NCT01857999
- Testing
- Losartan
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- InCor Heart Institute
Heart Failure, Sleep Apnea Syndromes
Treatment of Sleep Disordered Breathing In Acute Decompensated Heart Failure Patients
Heart Failure affects 5-6 million Americans and there are about 550 thousand new cases of heart failure every year. There are approximately 3 million hospital admission for acute decompensated heart failure with hospital…
- Trial name
- ARIA-II (NCT00804349)
- Testing
- Autotitrating Positive Airway Pressure
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Albert Einstein Healthcare Network
Heart Failure, Acute Coronary Syndrome
Timing of Coronary Angiography in NSTE-ACS With ADHF
The investigators hypothesized that immediate coronary angiography (CAG) within 2 hours after admission can reduce mortality compared to delayed CAG after stabilization of acute decompensated heart failure (ADHF) in patients with…
- Trial name
- EARLY-HF (NCT04810806)
- Testing
- Immediate coronary angiography within 2 hours after randomization, Delayed coronary angiography after stabilization of heart failure
- Where
- South Korea
- Volunteers
- 316 people
- Sponsor
- Chonnam National University Hospital
Heart Failure
Benefits of Microcor in Ambulatory Decompensated Heart Failure
To assess investigator engagement of μCor system data in the context of heart failure management. The μCor system includes a sensor and wearable patch for fluid management.
- Trial name
- BMAD-TX (NCT04096040)
- Testing
- μCor
- Where
- 83 sites in United States, Austria and 2 more
- Volunteers
- 265 people
- Sponsor
- Zoll Medical Corporation
Decompensated Heart Failure
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure
This study is designed to investigate the quantitative effects of sodium-free chloride supplementation on electrolyte balance, volume status, and sodium avidity in stable heart failure patients in a highly controlled environment.
- Trial name
- NCT03440970
- Testing
- Lysine Chloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Heart Failure
Effects of Early Cardiopulmonary Rehabilitation in Patients With Acute Decompensated Heart Failure
Acute decompensated heart failure (ADHF) is a severe condition characterized by rapid deterioration of cardiac function, leading to impaired oxygen delivery and multi-organ dysfunction.
- Trial name
- NCT07155421
- Testing
- Early Cardiopulmonary Rehabilitation, Routine in-hospital care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Izmir Bakircay University
Acute Decompensated Heart Failure
Cardionomic STOP-ADHF Study
STOP-ADHF Study: An evaluation of the safety and performance of the Cardionomic Cardiac Pulmonary Nerve Stimulation (CPNS) system in patients with acute decompensated heart failure.
- Trial name
- NCT04814134
- Testing
- CPNS Therapy, Standard of care
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 59 people
- Sponsor
- Cardionomic Inc.
Acute Heart Failure
Rivaroxaban Once Daily Versus Dose-adjusted Vitamin K Antagonist on the Biomarkers in Acute Decompensated Heart Failure and Atrial Fibrillation (ROAD HF-AF)
Vitamin K antagonists (VKAs) are used to reduce the risk of stroke (cerebral vascular dysfunction) in AF patients. However, VKAs interact with drugs/food and the drug level is influenced by worsening of renal function, liver…
- Trial name
- NCT03490994
- Testing
- Rivaroxaban, Warfarin + LMWH
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Yonsei University
Chronic Heart Failure
Safety and Efficacy Study of YM087 (Conivaptan) in Patients With Acute Decompensated Heart Failure
This is a randomized, double-blind, placebo-controlled, dose ranging pilot study to examine the effects of conivaptan in patients with acute decompensated heart failure.
- Trial name
- NCT00057356
- Testing
- conivaptan
- Where
- 26 sites in United States
- Volunteers
- 170 people
- Sponsor
- Cumberland Pharmaceuticals
Congestive Heart Failure
A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)
To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients
- Trial name
- NCT02047422
- Testing
- Furosemide, metolazone, furosemid/spironolactone
- Sponsor
- Yonsei University
Heart Failure
B-line by Lung US in Patients With Acute Decompensated Heart Failure
The purpose of this study is to evaluate that B-line detected by lung ultrasound before extubation in patients with acute decompensated heart failure can predict future risk of reintubation and clinical outcomes during admission…
- Trial name
- NCT04322851
- Testing
- Lung ultrasound
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center