Clinical trials: Death
Lung Transplant Failure
Prone Positioning in Neurologically Deceased Potential Organ Donors to Improve Donor Lung Function and Lung Transplant Recipient Outcomes
The purpose of this study is to determine the practicality of performing a future, large-scale study. The future study will look at the effect of mechanical ventilation in neurologically deceased (brain-dead) lung donors who are…
- Trial name
- P-POD (NCT06259357)
- Testing
- Protocolized protective mechanical ventilation in prone position
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Lorenzo delSorbo
Myocardial Infarction, Myocardial Infarction Old
CMR Based Prediction of Ventricular Tachycardia Events in Healed Myocardial Infarction (DEVELOP-VT)
Fibrotic tissue is known to be the substrate for the appearance of scar-related reentrant ventricular arrhythmias (VA) in chronic ischemic cardiomyopathy (ICM).
- Conditions
- Myocardial Infarction, Myocardial Infarction Old, Arrhythmias, Cardiac, Ventricular Tachycardia
- Trial name
- DEVELOP-VT (NCT04599439)
- Testing
- Cardiac magnetic resonance imaging
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Centro Medico Teknon
UC (Urothelial Cancer)
Pembrolizumab + Epacadostat vs Pembrolizumab + Placebo in Recurrent or Progressive Metastatic Urothelial Carcinoma
The purpose of this study was to evaluate the efficacy and safety of pembrolizumab + epacadostat vs pembrolizumab + placebo as a treatment for recurrent or progressive metastatic urothelial carcinoma in patients who have failed a…
- Trial name
- NCT03374488
- Testing
- Pembrolizumab, Epacadostat
- Where
- 135 sites in United States, Australia and 16 more
- Volunteers
- 84 people
- Sponsor
- Incyte Corporation
Preeclampsia, Fetal Death
Comparing the Effect of Vaginal Misoprostol With Dinoprostone in Term Pregnancies
Hypothesis (H0): Labor duration and obstetric complications are not significantly different in the three groups (misoprostol-dinoprostone-oxytocin).
- Conditions
- Preeclampsia, Fetal Death, Fetal Membranes, Premature Rupture
- Trial name
- NCT00432588
- Testing
- misoprostol, dinoprostone
- Where
- Iran
- Sponsor
- Hormozgan University of Medical Sciences
Bronchopulmonary Dysplasia, Premature
Autologous Cord Blood Mononuclear Cells for Bronchopulmonary Dysplasia in Very Preterm Neonates
Rationale: Pre-clinical animal studies provide robust evidence regarding the beneficial effect of cord blood-derived mononuclear cells (MNCs) for experimental bronchopulmonary dysplasia (BPD).
- Conditions
- Bronchopulmonary Dysplasia, Premature, Neonatal Death
- Trial name
- NCT02999373
- Testing
- Autologous Umbilical Cord Blood Mononuclear Cells Therapy
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Guangdong Women and Children Hospital
Liver Transplantation, Reperfusion
A Study of Retrograde rEperfusion in Dbd Donor LIver Transplantation
To evaluate whether retrograde caval reperfusion of liver graft could be superior over antegrade portal reperfusion in regard of incidence and severity of early allograft liver dysfunction.
- Conditions
- Liver Transplantation, Reperfusion, Delayed Graft Function
- Trial name
- REDLIT (NCT02423941)
- Testing
- Retrogade reperfusion, Antegrade reperfusion
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Republican Scientific and Practical Center for Organ and Tissue Transplantation
Pre-eclampsia, Obesity
ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes
Obesity is a growing problem in East London and every other woman who enters pregnancy is obese or overweight. In addition to obesity, other metabolic risk factors such as raised lipids, high blood pressure and diabetes increase…
- Conditions
- Pre-eclampsia, Obesity, Raised Lipids, High Blood Pressure
- Trial name
- ESTEEM (NCT02218931)
- Testing
- Targeted ESTEEM diet, Non-randomised cohort
- Where
- United Kingdom
- Volunteers
- 3,442 people
- Sponsor
- Queen Mary University of London
Cardiac Arrest, Sudden Death
A Comparative Study Between a Pre-hospital and an In-hospital Circulatory Support Strategy (ECMO) in Refractory Cardiac Arrest (APACAR2)
Cardiac arrest (CA) affects approximately 40,000 people in France. It is still a major cause of death in a young population. Management of CA is defined by international recommendations, detailed by learned societies in each…
- Trial name
- APACAR2 (NCT02527031)
- Testing
- ECMO Insertion on pre hospital setting, In Hospital ECMO
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy
Cardiac Arrhythmias in Dravet Syndrome
SUMMARY Rationale: People with Dravet Syndrome (DS), a rare epilepsy syndrome, have a high risk of Sudden Unexpected Death in Epilepsy (SUDEP).
- Trial name
- NCT02415686
- Where
- 3 sites in Germany, Netherlands and 1 more
- Volunteers
- 59 people
- Sponsor
- Stichting Epilepsie Instellingen Nederland
Dementia
Animal-Assisted Therapy for People With Dementia
This study is a qualitative anthropological research that explores the effects of Animal-Assisted Therapy (AAT) for people with moderate and severe dementia living in a care facility.
- Trial name
- AATPD (NCT03946696)
- Testing
- Interactions with therapy-animals
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Aberdeen
Kidney Transplant
Dosing Regimen of Eculizumab Added to Conventional Treatment in Positive Crossmatch Deceased Donor Kidney Transplant
The purpose of this study is to test whether a dosing regimen of eculizumab in addition to standard posttransplant care in positive crossmatch deceased donor kidney transplant recipients will reduce the incidence of acute humoral…
- Trial name
- NCT01106027
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Atrial Fibrillation
Early Atrial Fibrillation Ablation for Stroke Prevention in Patients With High Comorbidity Burden (EASThigh-AFNET 11)
EASThigh-AFNET 11 is an international, prospective, randomized, open, blinded endpoint assessment, multicenter trial (Treatment Strategy trial).
- Trial name
- NCT06324188
- Testing
- Early atrial fibrillation ablation, Usual Care
- Where
- 7 sites in Australia, Canada and 5 more
- Volunteers
- 2,312 people
- Sponsor
- Atrial Fibrillation Network
Congestive Heart Failure, Sudden Cardiac Death
Study of the Implantable Cardioverter Defibrillator (ICD) Intracardiac Electrograms
The purpose of this study is to determine whether waveforms of the intracardiac electrograms, acquired through an ICD, can be used: to predict malignant ventricular arrhythmias, requiring appropriate ICD therapies, and to predict…
- Conditions
- Congestive Heart Failure, Sudden Cardiac Death, Arrhythmia, Cardiomyopathies
- Trial name
- ICD-EGMs (NCT00916435)
- Where
- 2 sites in United States
- Volunteers
- 630 people
- Sponsor
- Johns Hopkins University
Sudden Cardiac Death, Left Ventricular Dysfunction
LifeVest Safety and Efficacy in Real Life Settings in France
This post-market study is a prospective observational study evaluating the efficacy and safety of the LifeVest in real-life settings.
- Conditions
- Sudden Cardiac Death, Left Ventricular Dysfunction, Cardiac Event, Cardiac Arrythmias
- Trial name
- WEARIT-FR (NCT03319160)
- Testing
- Wearable Cardioverter Defibrillator
- Where
- 2 sites in France
- Volunteers
- 1,164 people
- Sponsor
- Zoll Medical Corporation
Breast Neoplasms
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
The purpose of this study is to compare sacituzumab tirumotecan as a single agent, and in combination with pembrolizumab, versus Treatment of Physician's Choice (TPC) in participants with hormone receptor positive/human epidermal…
- Trial name
- NCT06312176
- Testing
- Sacituzumab tirumotecan, Pembrolizumab, Paclitaxel
- Where
- 259 sites in United States, Argentina and 38 more
- Volunteers
- 1,200 people
- Sponsor
- Merck Sharp & Dohme LLC
COVID-19 Disease
Systematic Assessment of SARS-CoV-2 Neurotropic Capacity in Modestly and Critically Ill Patients, and Patients Who Died From COVID-19
This study is to analyze the microglia reaction or direct neurotropic effects of CNS COVID-19 in pathogenesis and brain stem dysfunction in critically ill patients.
- Trial name
- NCT04472013
- Testing
- Data collection from lumbar puncture, Data collection from blood draw, CNS magnetic resonance imaging (MRI) imaging
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiac Arrest, Sudden
AED Log Analysis of 19 Cases in Out-of-hospital Environment
The study performed to demonstrate a reasonable assurance of safety and effectiveness of the Heart Guardian HR-501 when used in an out-of-hospital environment.
- Trial name
- NCT03969797
- Testing
- RADIAQBIO Heart Guardian HR-501
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- RadianQbio
Epilepsy, Seizures
Neural Circulatory Control and SUDEP Risk.
The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP).
- Trial name
- NC-SUDEP (NCT02813980)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Death, Infant, Morbidity;Infant
Trial to Compare Two Strains of BCG
The trial will be a two-year outcome assessor-blinded RCT at the maternity ward of hospital Simão Mendes (HNSM) in urban Bissau, Guinea-Bissau to compare BCG-Japan versus BCG-Russia 1:1 in 15,000 infants with respect to…
- Trial name
- STRAIN III (NCT04383925)
- Testing
- BCG-Japan, BCG-Russia
- Where
- Guinea-Bissau
- Volunteers
- 16,390 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Prenatal Care
Prenatal Care Program in Dingyuan County
The general objective of this study is to evaluate prenatal care in the specific context of rural China. It also aims to define the optimal content of prenatal care for the context of rural China, to evaluate the effect of such…
- Trial name
- EPCP (NCT01054235)
- Testing
- training
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Finnish Institute for Health and Welfare