Clinical trials: Death
Colorectal Cancer
A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)-China Extension Study
The purpose of this China extension study is to assess the safety and efficacy of coformulated favezelimab/pembrolizumab (MK-4280A) in adult Chinese participants with metastatic colorectal cancer.
- Trial name
- NCT05600309
- Testing
- favezelimab/pembrolizumab, regorafenib, TAS-102
- Where
- 24 sites in China
- Volunteers
- 94 people
- Sponsor
- Merck Sharp & Dohme LLC
Nonsquamous Non-small Cell Lung Cancer
Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)-China Extension Study
The purpose of this study is to assess the safety and efficacy of pemetrexed+platinum chemotherapy+pembrolizumab (MK-3475) with or without lenvatinib (MK-7902/E7080) as first-line intervention in adults from mainland China with…
- Trial name
- NCT04716933
- Testing
- Pembrolizumab, Carboplatin, Cisplatin
- Where
- 19 sites in China
- Volunteers
- 201 people
- Sponsor
- Merck Sharp & Dohme LLC
Maternal Death, Newborn Death
Impact of the Safe Childbirth Checklist in Luapula Province of Zambia Province of Zambia
This study would like to determine if the introduction of the Safe Childbirth Checklist and associated mentorship can improve the adherence of skilled birth attendants (SBAs) to the essential practices of childbirth delivery.
- Trial name
- NCT03263182
- Testing
- Introduction of the Safe Childbirth Checklist
- Where
- 4 sites in Zambia
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Clinton Health Access Initiative Inc.
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
Early Initiation of Extracorporeal Life Support in Refractory OHCA
Despite adequate conventional cardiopulmonary resuscitation (CCPR) and attempted defibrillation, a considerable number of patients in cardiac arrest fail to achieve sustained return of spontaneous circulation.
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Death
- Trial name
- INCEPTION (NCT03101787)
- Testing
- Extracorporeal cardiopulmonary resuscitation (ECPR)
- Where
- 10 sites in Netherlands
- Volunteers
- 134 people
- Sponsor
- Maastricht University Medical Center
Sudden Infant Death Syndrome
Factors Influencing the Racial Disparity in Sudden Infant Death Syndrome (SIDS)
The overall purpose of this investigation is to better understand factors contributing to the high incidence of prone sleep positioning in African-American infants.
- Trial name
- SIDS (NCT01361893)
- Testing
- Lifestyle Counseling
- Where
- United States
- Volunteers
- 616 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cardiac Arrest, Ventricular Fibrillation
The OSIRIS ECPR Trial
The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal…
- Conditions
- Cardiac Arrest, Ventricular Fibrillation, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Arrest
- Trial name
- OSIRIS (NCT06805344)
- Testing
- Extracorporeal cardiopulmonary resuscitation based approach, Conventional cardiopulmonary resuscitation
- Volunteers
- 686 people
- Sponsor
- General University Hospital, Prague
Sudden Cardiac Death
Assessment of Primary Prevention Patients Receiving An ICD - Systematic Evaluation of ATP
The primary objective is to understand the role of antitachycardia pacing (ATP) in primary prevention patients indicated for implantable cardioverter-defibrillator (ICD) therapy and programmed according to current guidance of…
- Trial name
- APPRAISE ATP (NCT02923726)
- Testing
- Arm 1 (ATP+Shock), Arm 2 (shock only)
- Where
- 134 sites in United States, Austria and 6 more
- Volunteers
- 2,692 people
- Sponsor
- Boston Scientific Corporation
Abortion, Second Trimester, PPROM
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from diagnosis of nonviable…
- Conditions
- Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise
- Trial name
- MIST (NCT05322252)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Leukemia, Promyelocytic, Acute
Impact of a Simplified Patient Care Strategy to Decrease Early Deaths in Acute Promyelocytic Leukemia (APL) by Maintaining a Database
Acute promyelocytic leukemia (APL) is a very rare type of leukemia. Because it is so rare, many doctors do not have experience treating it. APL has been shown to be curable most of the time.
- Trial name
- NCT02309333
- Where
- 4 sites in United States
- Volunteers
- 117 people
- Sponsor
- Emory University
Sudden Cardiac Death
The International SubcutaneouS Implantable Cardioverter Defibrillator Registry (iSuSI)
The entirely subcutaneous implantable defibrillator (S-ICD) (Emblem, Boston Scientific, Marlborough, MA, USA) was introduced as a new therapeutic alternative to the conventional transvenous ICD in 2009 and implantations are…
- Trial name
- iSuSI (NCT05390047)
- Where
- Germany
- Volunteers
- 4,000 people
- Sponsor
- University of Luebeck
Cerebrovascular Event, Stent Stenosis
Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter Implantation
APICES trial is an investigator-initiated, multicenter, multicenter, randomized, double-blind, placebo-controlled clinical trial that plans to enroll 396 patients with a 1-year follow-up, including a neurovascular imaging…
- Conditions
- Cerebrovascular Event, Stent Stenosis, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT06308952
- Testing
- Atorvastatin 20mg
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Duan Chuanzhi
Septic Shock, Multiple Organ Failure
Severe Sepsis/Septic Shock on Admission to the General Surgical ICU
Severe sepsis/septic shock are serious complications of infection with high morbidity and mortality. Recent information showed that early and aggressive resuscitation may help improving survival and outcome especially the…
- Conditions
- Septic Shock, Multiple Organ Failure, Fatal Outcome
- Trial name
- NCT01363635
- Where
- Thailand
- Volunteers
- 800 people
- Sponsor
- Mahidol University
Delayed Function of Renal Transplant
Effects of the Use of "de Novo" Everolimus in Renal Tranplant Population
This is an open, randomized, single-center study. The selected patients will be first divided into two major groups according to the type of organ to be transplanted: standard criteria donor (SCD) or extended criteria (ECD)…
- Trial name
- NCT01663805
- Testing
- Everolimus
- Where
- 3 sites in Brazil
- Volunteers
- 80 people
- Sponsor
- MARIO ABBUD FILHO
Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome
Hearts in Rhythm Organization (HiRO)National Registry and Bio Bank
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), Long QT Syndrome (LQTS)
- Trial name
- HiRO (NCT04189822)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of British Columbia
High Risk Pregnancy
Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies
Pregnancies resulting in IUGR and also in preeclampsia are strongly associated with typical underlying placental pathology revealing small placentas and maldevelopment of the decidual blood vessels, suggesting under-perfusion…
- Trial name
- NCT01355822
- Testing
- PETN
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- University of Jena
Out-Of-Hospital Cardiac Arrest, Cardiac Arrest, Sudden
The Scandinavian AED and Mobile Bystander Activation Trial
Sudden cardiac death is a major health problem in the western world. In Europe alone nearly 300 000 patients are affected annually.
- Trial name
- SAMBA (NCT02992873)
- Testing
- Layperson allocated to start CPR and fetch nearest AED, Layperson allocated to start CPR
- Where
- 2 sites in Sweden
- Volunteers
- 815 people
- Sponsor
- Karolinska Institutet
Terminal Illness
ADJUST: A Study on MDT Prognostication
This study investigates how clinicians form intuitive judgements about the prognoses of palliative care patients after receiving advice perceived as coming from either a team member or an algorithm.
- Trial name
- ADJUST (NCT04568629)
- Testing
- Advice from the PiPS-B14 prognostic tool, Advice from another clinician
- Where
- United Kingdom
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- University College, London
Cardiovascular Disease (CVD), Cardiovascular Risk Factor
Women's Advanced Risk-assessment in Manitoba
The main objective of this study is to test the ability of novel cardiovascular disease (CVD) prognostic tools to identify women at risk for future CVD. We plan to establish a cardiovascular health screening program at the St.
- Conditions
- Cardiovascular Disease (CVD), Cardiovascular Risk Factor, Vascular Stiffness
- Trial name
- WARM (NCT03938155)
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- St. Boniface Hospital
Palliative Care
A Family-Centered Intervention When a Parent is Cared for in Specialized Homecare
The overall purpose of this project is to evaluate a family-centered intervention (the Family Talk Intervention, by W. Beardslee) in families where a parent of children aged 6-19 years is seriously ill and cared for in…
- Trial name
- NCT03119545
- Testing
- Beardslee family centered intervention
- Where
- Sweden
- Volunteers
- 33 people
- Sponsor
- Ersta Sköndal University College
SUDEP
Risk Factors for Sudden Unexplained Death in Epilepsy
The main purpose of this study is to develop a North American registry for SUDEP cases; requesting family members of epilepsy patients who died suddenly of unclear causes (SUDEP) to contact the study team.
- Trial name
- SUDEP (NCT01662453)
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health