Clinical trials: Deafness
Sensorineural Hearing Loss (Disorder)
Clinical Applications of Round Window Imaging Anatomy in Cochlear Implant Surgery
The purpose of this study is to measure the size of the round window niche and its relation to the mastoid segment of the facial nerve and the mastoid cortex, using high resolution computerized tomography of the temporal bone, in…
- Trial name
- NCT02093806
- Testing
- measurment
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Bnai Zion Medical Center
Sensorineural Hearing Loss, Bilateral, Sensorineural Hearing Loss, Severe
Post Approval Study to Assure the ContInued saFety and effectIveness of Neuro Cochlear Implant System in Adult Users
On June 23, 2021, the Oticon Medical Neuro Cochlear Implant System (NCIS) was granted premarket approval (PMA) in the US to treat individuals 18 years or older, with bilateral severe-to-profound sensorineural hearing loss, who…
- Conditions
- Sensorineural Hearing Loss, Bilateral, Sensorineural Hearing Loss, Severe, Sensorineural Hearing Loss, Profound
- Trial name
- PACIFIC (NCT05154188)
- Testing
- Neuro Cochlear Implant system
- Volunteers
- 60 people
- Sponsor
- Oticon Medical
Hearing Impaired Children
Project PAIR: Parent-implemented Articulation Intervention With Recast
Using a single-case multiple baseline across participants design, this study aims to explore the effectiveness of parent-implemented Broad Treatment Speech Recast supplemented with traditional clinician-led articulation therapy…
- Trial name
- Project PAIR (NCT06936696)
- Testing
- Broad Target Speech Recast, Traditional Speech Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt University
Usher Syndromes
Safety and Efficacy of NPI-001 Tablets for RP Associated With Usher Syndrome
This study will examine the safety and efficacy of NPI-001 Tablets as compared to placebo for 24 months in subjects with vision loss due to RP associated with Usher syndrome.
- Trial name
- SLO RP (NCT04355689)
- Testing
- NPI-001
- Where
- 4 sites in Australia
- Volunteers
- 49 people
- Sponsor
- Nacuity Pharmaceuticals, Inc.
Hearing Loss, Sensorineural, Noise Induced Hearing Loss
FX-322 in Adults With Acquired Sensorineural Hearing Loss
This is a Phase 2, prospective, randomized, double-blind, placebo-controlled, single-dose, multicenter study to evaluate the efficacy of FX-322, administered by intratympanic injection, in adults with acquired sensorineural…
- Conditions
- Hearing Loss, Sensorineural, Noise Induced Hearing Loss, Sudden Hearing Loss
- Trial name
- NCT05086276
- Testing
- FX-322
- Where
- 26 sites in United States
- Volunteers
- 142 people
- Sponsor
- Frequency Therapeutics
Hearing Loss, Sensorineural Hearing Loss
Quality Control of CE-Certified Phonak Hearing Aids - 2019_19
Phonak Hearing Systems pass through different development and study stages. At an early stage, feasibility studies are conducted to investigate new algorithms, features and functions in an isolated manner.
- Trial name
- NCT03992989
- Testing
- Phonak Bolero M90-M, Roger Select
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Sonova AG
Hearing Impairment
The Performance-Perceptual Test as a Counseling Tool
The purpose of the study is to determine whether a new test of ability to understand speech in noise and an associated counseling program can improve hearing aid satisfaction.
- Trial name
- PPT (NCT00126113)
- Testing
- PPT-based Counseling, Standard Educational Counseling
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- US Department of Veterans Affairs
Cisplatin Ototoxicity, Hearing Loss
Randomized Trial Comparison of Ototoxicity Monitoring Programs
This study involves research. Some chemotherapeutic drugs that can permanently reduce hearing are termed "ototoxic". One such drug is the chemotherapy called cisplatin.
- Trial name
- COMP-VA (NCT02099786)
- Testing
- COMP-VA, Standard of care
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Temporary Auditory Threshold Shift
Otoprotection With SPI-1005 for Prevention of Temporary Auditory Threshold Shift
Exposure to loud sounds can cause hearing loss. The purpose of this research study is to evaluate potential prevention of temporary changes in hearing that may occur after listening to music through an iPod or personal music…
- Trial name
- NCT01444846
- Testing
- SPI-1005 Low dose, SPI-1005 Middle dose, SPI-1005 High dose
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Sound Pharmaceuticals, Incorporated
Hearing Loss, Conductive, Hearing Loss, Unilateral
Adhear Bone Conduction System
The purpose of this research study is to learn about the hearing outcomes of adult and pediatric patients who are treated with or are candidates for bone conductive devices (also termed "BAHA").
- Trial name
- NCT03533686
- Testing
- Adhear Bone Conduction System, Bone anchored hearing aid (BAHA)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Miami
Vestibular Disorder, Hearing Loss, Sensorineural
Sensory Integration of Auditory and Visual Cues in Diverse Contexts
More than 1/3 of adults in the United States seek medical attention for vestibular disorders and hearing loss; disorders that can triple one's fall risk and have a profound effect on one's participation in activities of daily…
- Trial name
- NCT04479761
- Testing
- Visual and Auditory Cues
- Where
- 2 sites in United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- New York University
Hearing Loss
Nucleus Hybrid L24 Extended Duration Post Approval Study
This post approval study evaluates the long term safety and efficacy of the Nucleus Hybrid L24 Implant System in a group of already implanted recipients.
- Trial name
- HED (NCT02379273)
- Testing
- Nucleus Hybrid L24 Implant
- Volunteers
- 35 people
- Sponsor
- Cochlear
Hearing Loss
Extra-cochlear Electrode Placement at the Post-auricular Vagus Nerve in Cochlear Implantation
This study will evaluate hearing outcomes after cochlear implantation with placement of the ECE1 ground electrode near the post-auricular vagus nerve (Arnold's nerve) to assess non-inferiority with respect to placement under the…
- Trial name
- NCT07011927
- Testing
- Cochlear Implant, Modified Implant Procedure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- NYU Langone Health
Hearing Loss
Wind Noise Sound Quality Preference and Claims Study
Claims evidence is required for a new Wind Noise Canceller (WNC) algorithm. Wind noise is not sound in the classic sense, as it does not correspond to pressure waves moving through the air.
- Trial name
- WB (NCT07543770)
- Testing
- New wind noise canceller, Old wind noise canceller
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Jonathan Vaisberg
Hearing Loss, Sensorineural, Cochlear Synaptopathy
Evaluation of the CochSyn Test Prototype to Measure Cochlear Synaptopathy
This study investigates a newly developed test, The CochSyn test that can quantify cochlear synaptopathy (CS) (a new type of sensorineural hearing loss (SNHL)) earlier than the current golden standard pure-tone audiogram.This…
- Conditions
- Hearing Loss, Sensorineural, Cochlear Synaptopathy, Cochlear Hearing Loss
- Trial name
- EarDiTech (NCT06114680)
- Testing
- CochSyn test prototype, Universal Smart Box (USB)
- Where
- Belgium
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University Ghent
Peripheral Artery Disease
Angiogenesis and Blood Perfusion Effect of HGF Gene Therapy in PAD Patients
The purpose of this study is to evaluate whether PET/CT-RGD or MIBI can be used for the angiogenesis assessment of NL003 in PAD patients.
- Trial name
- NCT05968118
- Testing
- NL003
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Beijing Northland Biotech. Co., Ltd.
Hearing Loss
Usability of the CP950 Sound Processor
Studying usability and gaining feedback of the CP950 Sound Processor in experienced cochlear implant recipients.
- Trial name
- C950 (NCT02727842)
- Testing
- CP950 Sound Processor, Wireless programming pod
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cochlear
Deafness, Sound Perception
Cochlear Implant Speech and Non-speech Sound Recognition
The primary purpose of the research is to study how synthesized speech and non-speech percepts (sounds) are recognized in subjects with cochlear implants (CI) who are not getting functional speech recognition using existing…
- Conditions
- Deafness, Sound Perception, Quality of Sound
- Trial name
- NCT03661970
- Testing
- Cognate Speech Synthesizer sound percepts
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pacific Northwest University of Health Sciences
Hearing Loss
An Investigation to Validate Speech Perception Assessment for Adult Cochlear Recipients Using a Mobile Research App
The study is a feasibility, prospective, repeated-measures, multi-country, multi-centre, study of the Mobile Research App to measure and validate speech perception endpoints in adult cochlear implant recipients.
- Trial name
- VALDE-MU (NCT06098482)
- Testing
- Mobile Research App (MRA), SOC/validated delivery of the speech perception test material
- Where
- 4 sites in United States, Australia and 1 more
- Volunteers
- 46 people
- Sponsor
- Cochlear
Sensorineural Hearing Loss, Deafness
Cochlear Implant and Vestibular Function.
This study investigate weather one type of cochlear implant (CI) surgery (insertion of the electrode via paracentesis of the round window (RWA)) leads to less vertigo than another type of CI surgery (cochleostomy).
- Conditions
- Sensorineural Hearing Loss, Deafness, Hearing Loss
- Trial name
- NCT02584361
- Testing
- Round window approach, Cochleostomy
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital