Clinical trials: DED
Dry Eye Disease
Vizol S Lipid Balance Efficacy and Safety Study in Patients With Dry Eye
The clinical investigation was intended to investigate the efficacy, ocular tolerability and safety of Vizol S Lipid Balance, a new eye drops, emulsion developed by JADRAN - GALENSKI LABORATORIJ d.d., in patients with moderate to…
- Trial name
- NCT06323395
- Testing
- Vizol S LIPID BALANCE eye drops, ophthalmic saline eye drops
- Where
- 2 sites in Serbia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Jadran Galenski laboratorij d.d.
Dry Eye Disease (DED)
The Effect of 0.1% Topical Ciclosporin A for 12-weeks on the Eye Surface Immune Cells in Dry Eyes
Dry eye disease (DED) is a common, long-lasting condition that affects the surface of the eye. It happens when there's a problem with tear production or quality, which can lead to inflammation and discomfort.
- Trial name
- NCT06898853
- Testing
- 0.1% Ciclosporin A eye drops, Mineral oils eye drops
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The University of New South Wales
Dry Eye, Dry Eye Disease (DED)
A Study in the Treatment of Mild to Moderate Dry Eye Disease Comparing Saline to TTAX03.
The purpose of this randomized, controlled, multicenter study is to evaluate the safety and efficacy of TTAX03 in participants with mild to moderate DED. The primary question it aims to answer is if TTAX03 is safe.
- Conditions
- Dry Eye, Dry Eye Disease (DED), Dry Eye Disease With Severe Keratitis
- Trial name
- NCT06780306
- Testing
- TTAX03
- Where
- 9 sites in United States
- Volunteers
- 74 people
- Sponsor
- BioTissue Holdings, Inc
Dry Eye Disease (DED)
A Clinical Study Evaluating Licaminlimab for Dry Eye Disease
The primary objective of this study is to evaluate the efficacy and safety of the topical ophthalmic administration of licaminlimab as compared to vehicle in participants with Dry Eye Disease and a specific genotype.
- Trial name
- PREDICT-1 (NCT07548632)
- Testing
- Artificial Tear Run-in, licaminlimab, Vehicle of licaminlimab
- Where
- 14 sites in United States
- Volunteers
- 160 people
- Sponsor
- Oculis
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Dry Eye Assessment and Management: Feasibility Study
The purpose of this study is to test a protocol investigating the efficacy of omega-3 fatty acids in treating dry eye disease. The study is termed "feasibility" because its purpose is to demonstrate an ability to execute the…
- Trial name
- DREAM (NCT01102257)
- Testing
- Omega-3 EFA Supplement, Olive Oil
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Asbell, Penny, M.D.
Dry Eye Disease (DED)
Phase 3 Study of EBI-005 in Dry Eye Disease
This is a phase III double-masked, randomized, controlled study evaluating the efficacy of EBI-005 as compared to vehicle given as a topical ophthalmic solution in each eye to subjects with moderate to severe DED three times…
- Trial name
- EBI-005 (NCT01998802)
- Testing
- Active Comparator EBI-005
- Where
- 45 sites in United States
- Volunteers
- 670 people
- Sponsor
- Eleven Biotherapeutics
Dry Eye Syndromes
Fingerprick Autologous Blood (FAB) in Severe Dry Eye Disease (DED)
Dry eye disease (DED) is an umbrella term encompassing a range of diseases estimated to affect 14% of all adults aged 48 to 91. If left untreated, DED can lead to severe reduction in the quality of life of the sufferer.
- Trial name
- FAB (NCT03395431)
- Testing
- Fingerprick autologuos blood (FAB)
- Volunteers
- 60 people
- Sponsor
- Bedford Hospital NHS Trust
Dry Eye
An Observational Study to Assess Next Generation Emulsion Preservative Free Eye Drops (NGE-UD) on Dry Eye Symptoms and Quality of Life of Adult Participants With Mild to Moderate Dry Eye Disease (DED)
Dry Eye Disease (DED) is a condition where the tear film of the eye becomes unstable and along with ocular surface inflammation and damage leads to inadequate tear production and eye lubrication.
- Trial name
- NCT06443775
- Testing
- Next Generation Emulsion Preservative Free Eye Drops (NGE-UD)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- AbbVie
Postmenopausal Women With DED
A Study for the Treatment of Dry Eye in Postmenopausal Women
A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of EG017 Ointment for the Treatment of Dry Eye in Postmenopausal Women
- Trial name
- NCT06133166
- Testing
- EG017 ointment
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Dry Eye Disease (DED)
Long-Term Safety and Tolerability of NOV03 (Perfluorohexyloctane) in Subjects Who Completed Trial NVU-003 (Kalahari Study)
The objectives of this trial are to evaluate the safety and tolerability of perfluorohexyloctane (NOV03) ophthalmic solution during long-term use in subjects with Dry Eye Disease (DED) associated with MGD (Meibomian Gland…
- Trial name
- NCT04140227
- Testing
- NOV03
- Where
- 28 sites in United States
- Volunteers
- 256 people
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye Disease (DED)
Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Surgery
To review how patients report using a hyaluronate crosslinked canalicular gel placed before cataract surgery
- Trial name
- LaReCa (NCT07155057)
- Testing
- Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Meibomian Gland Dysfunction, Dry Eye Disease
Clinical Study Evaluating Nordlys™ SWT IPL for Dry Eye Disease (DED) Due to MGD
Clinical Study Evaluating Nordlys™ System with Selective Waveband Technology (SWT)® Intense Pulsed Light (IPL) Applicators for Dry Eye Disease (DED) due to Meibomian Gland Dysfunction (MGD).
- Trial name
- NCT06064071
- Testing
- Nordlys SWT IPL, Meibomian Gland Expression (MGX)
- Where
- 3 sites in United States, Argentina
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Dry Eye Disease (DED)
TRYPTYR as a Treatment for Patients With Dry Eye Disease (DED)
The purpose of this research study is to determine the effectiveness of TRYPTYR as a treatment for Dry Eye Disease. The primary efficacy variable is change from baseline in the Ocular Surface Disease Index (OSDI) at week 2.
- Trial name
- NCT07732010
- Testing
- TRYPTYR (Acoltremon ophthalmic solution 0.003%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Dry Eye Disease (DED)
Photobiomodulation in Combination With Topical Cyclosporine A or Tacrolimus
The objective of the study is to evaluate the effectiveness of Low-level light therapy (LLLT) in combination with either topical Cyclosporine A (CsA) or topical Tacrolimus, using each non-steroidal immunosuppressant as an active…
- Trial name
- NCT07239128
- Testing
- Low-level light therapy (LLLT), Topical Cyclosporine A, Topical tacrolimus
- Where
- 2 sites in Italy
- Volunteers
- 160 people
- Sponsor
- University of Seville
Dry Eye Disease (DED)
The Effectiveness of Systane PRO Preservative Free Verses Blink Triple Care Preservative Free
The goal of this investigational study is to determine if Systane PRO Preservative Free is non-inferior to BLINK TRIPLE CARE in the clinically significant improvement of signs and symptoms of dry eye in patients over 4 weeks.
- Trial name
- SYSTANEvBLINK (NCT07745062)
- Testing
- Systane PRO, Blink tears
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Gordon Schanzlin New Vision
Ocular Inflammation, Keratoconjunctivitis
Tolerability Comparison of Flarex to Lotemax SM
This study compared the ocular tolerability of fluorometholone acetate ophthalmic suspension 0.1% (FLAREX) to loteprednol etabonate ophthalmic gel 0.38% (Lotemax SM) in adult subjects.
- Conditions
- Ocular Inflammation, Keratoconjunctivitis, Dry Eye Disease (DED), Post-operative Complications
- Trial name
- NCT07588074
- Testing
- Fluorometholone Acetate Ophthalmic Suspension 0.1%, Loteprednol Etabonate Ophthalmic Gel 0.38%
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Harrow Inc
Dry Eye Disease (DED)
Perfluorohexyloctane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)
This study will evaluate the efficacy, safety and tolerability of perfluorohexyloctane (NOV03) at two different dosing regimens compared to saline solution in subjects with Dry Eye Disease (DED).
- Trial name
- NCT03333057
- Testing
- NOV03
- Where
- 11 sites in United States
- Volunteers
- 336 people
- Sponsor
- Novaliq GmbH
Dry Eye Disease (DED)
Efficacy and Safety of VMX Eye Drops for Dry Eye Disease
This multicenter, randomized, double-blind study evaluates the safety and effectiveness of VMX eye drops in patients with dry eye disease.
- Trial name
- NCT07369375
- Testing
- VMX Eye Drops
- Volunteers
- 76 people
- Sponsor
- VISUfarma SpA
DED, Aqueous-deficient Dry Eye Disease
Upper Punctal Plug Occlusion in Previous Lower Punctal Occlusion.
This study evaluates the therapeutic effect of upper punctal plug occlusion in patients with dry eye disease with previous lower punctal occlusion.
- Trial name
- NCT07571330
- Testing
- Punctal plug occlusion
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Dry Eye Disease (DED)
Using Dry Eye As a Disease Model, Investigators Demonstrated the Optimal Selection of Individualized Clinical Interventions and the Superiority of Dynamic Treatment Discrimination in Chinese Medicine.
In this study, dry eye disease (leukoaraiosis) is used as a model disease, and the methodological system for evaluating the clinical efficacy of Chinese medicine for dry eye disease is constructed with the core of "subgrouping…
- Trial name
- DED OSDI FBUT (NCT06605495)
- Testing
- fumigation with Chinese medicine, Oral herbal medicine, Modern Western Medicine
- Volunteers
- 4,000 people
- Sponsor
- Xuejing Lu