Clinical trials: Cystic Fibrosis (CF)
Cystic Fibrosis, Vitamin D Deficiency
Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients
The main aim of the research question to test the primary hypothesis of this study, namely, Does 12 weeks of an additional 5000 IU daily of cholecalciferol increase serum 25OHD levels in adults with Cystic Fibrosis (CF) who have…
- Trial name
- NCT00685971
- Testing
- 5000 IU of cholecalciferol
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis, Depressive Symptoms
Bright Light Therapy for Depression Symptoms in Adults With Cystic Fibrosis (CF) and COPD
This is a project that will determine whether the use of daily bright light therapy has an effect on depressive symptoms experienced by adult inpatients with CF and COPD.
- Conditions
- Cystic Fibrosis, Depressive Symptoms, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT04921332
- Testing
- Bright Light Therapy (BLT) Lamp
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Erica Osborn
Cystic Fibrosis
Prospective Study of the Phenotypic Expression of Cystic Fibrosis (CF) Screened Positive Newborns With an Atypical Form of CF (DPAM)
The strategy of neonatal screening for Cystic Fibrosis in France relies on Immuno Reactive Trypsinogen (IRT) at day 3/DNA analysis with a CF Elucigen 30 mutations kit/ IRT safety-net at day 21.
- Trial name
- DPAM (NCT02869932)
- Testing
- Lung CT scan
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis, COVID-19
COVID-19 Antibody Responses in Cystic Fibrosis
Coronavirus disease 2019 (COVID-19) which is caused by the virus SARS-CoV-2 has resulted in an ongoing global pandemic. It is unclear whether the relatively low number of reported cases of COVID-19 in people with CF (pwCF) is due…
- Trial name
- CAR-CF (NCT05561868)
- Where
- 2 sites in Ireland
- Volunteers
- 70 people
- Sponsor
- Children's Health Ireland
Diabetes, Cystic Fibrosis
Training in Shared Decision-making of Cystic Fibrosis Centers Competences in the Treatment of CF Related Diabetes in Adult Patients
Diabetes affects half of cystic fibrosis patients aged 30 years and older. It develops asymptomatically for a long time. Also, two options are possible: start insulin treatment now with the additional constraints associated with…
- Trial name
- FORAIDMUCO (NCT04891159)
- Testing
- Shared decision making
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Cystic Fibrosis
Comparison of 129Xe MRI With 19F MRI in CF Lung Disease
This study is designed to compare the capabilities of two novel imaging techniques: polarized perfluorinated gas mixed with oxygen, and hyperpolarized xenon mixed with N2 to detect changes in lung ventilation using MRI.
- Trial name
- NCT03482960
- Testing
- Hyperpolarized Xenon gas, PFP
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cystic Fibrosis
ELX/TEZ/IVA Expanded Access Program for Cystic Fibrosis (CF) Patients With at Least One F508del Mutation
The purpose of this program is to provide elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) to CF patients in critical need who are 6 to 11 years of age with at least one F508del mutation in response to unsolicited physician…
- Trial name
- NCT04702360
- Testing
- ELX/TEZ/IVA, IVA
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis
Analysis of Remote Monitoring/Virtual Clinic Data in Adult Patients With Cystic Fibrosis (Project Breathe)
The goal of this observational study is to learn about the impact of home monitoring in adults with cystic fibrosis. The main questions it aims to answer are: how people with CF find using home monitoring equipment to see if by…
- Trial name
- NCT06222905
- Testing
- non interventional
- Where
- 2 sites in United Kingdom
- Volunteers
- 475 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Cystic Fibrosis (CF)
A Precision Medicine Approach to Assess Protein Function Loss and the Potential for CFTR Function Restoration in Cystic Fibrosis and Related Disorders
This multicenter translational research study integrates diagnostic analyses and ex-vivo functional testing to support future clinical trials evaluating the safety and efficacy of CFTR modulator treatments in individuals with…
- Trial name
- VALPERPRO-CFTR (NCT07889973)
- Where
- 3 sites in Italy
- Volunteers
- 165 people
- Sponsor
- Istituto Giannina Gaslini
Cystic Fibrosis
Development and Validation of a Disease Specific PROM to Assess Abdominal Involvement in Patients With CF (CFAbd-Score)
Development, validation and evaluation of a new multimodal questionnaire to assess and quantify the abdominal involvement in patients with the inherited life shortening multi-organ disease Cystic fibrosis.
- Trial name
- CFAbd-Score (NCT03052283)
- Testing
- Questionnaire Patient Reported Outcome Measure (PROM)
- Where
- 2 sites in Germany
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Cystic Fibrosis
Mucin in Sputum of CF During Pulmonary Exacerbation
The purpose of this study is to determine whether mucin is increased during pulmonay exacerbations in adult patients with cystic fibrosis (CF).
- Trial name
- NCT00202072
- Where
- 2 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Philipps University Marburg
Cystic Fibrosis
Study of Yoga as a Therapy for Cystic Fibrosis (CF) Patients
Cystic fibrosis (CF) is a lung disease that affects 30,000 children and adults in the US. Incorporation of regular exercise into the lives of patients with CF is of interest because it may improve lung function and quality of…
- Trial name
- NCT01325766
- Testing
- Yoga
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Seattle Children's Hospital
Cystic Fibrosis
Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF
This project is an attempt to understand how Orkambi treatment affects exercise capacity and the function of the arteries in CF patients who are homozygous F508del.
- Trial name
- NCT03338595
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Augusta University
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Simplification of CF-related Diabetes Screening at Home
Cystic fibrosis (CF)-related diabetes (CFRD) is the most common complication after pulmonary complications. This specific form of diabetes is associated with an increased morbidity and mortality.
- Trial name
- AtHome (NCT03227094)
- Testing
- Standard OGTT, Home-based OGTT (Beverage), Home-based OGTT (Candy)
- Where
- 2 sites in Canada
- Volunteers
- 37 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Cystic Fibrosis
LBM & Lung Function in Adolescents With CF
In patients with cystic fibrosis (CF) the commonest cause of death is respiratory failure. Respiratory failure can have many causes.
- Trial name
- NCT02797912
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- King's College Hospital NHS Trust
Cystic Fibrosis, Non-CF Bronchiectasis
Regional Phenotyping of CF and Non-CF Bronchiectasis
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy…
- Trial name
- NCT04793867
- Testing
- Xenon
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis (CF)
The School-Age Children With Cystic Fibrosis and Their Parents on Health Literacy
This randomized controlled experimental study is planned to examine the effect of an online education program provided to school-age children aged 6-11 years diagnosed with cystic fibrosis and their parents on health literacy…
- Trial name
- NCT07304362
- Testing
- Online Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Cystic Fibrosis, Chronic Bronchitis
Standard vs. Biofilm Susceptibility Testing in Cystic Fibrosis (CF)
This was a randomized multi-center clinical trial to compare the microbiological efficacy, clinical efficacy, and safety of using standard versus biofilm susceptibility testing of P.
- Trial name
- NCT00153634
- Testing
- IV amikacin, PO azithromycin, IV ceftazidime
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- Seattle Children's Hospital
Cystic Fibrosis (CF)
Group Cognitive Behavioural Therapy for Adults With Cystic Fibrosis
The overall goal of this clinical trial is to: a) explore the feasibility, acceptability, and participant experiences with the group version of CF-CBT; b) examine the effectiveness of the virtual delivery of a group version of…
- Trial name
- NCT06645782
- Testing
- Virtual, Group CF-CBT
- Where
- 2 sites in Canada
- Volunteers
- 21 people
- Sponsor
- University of Regina